scholarly journals Asthmatic children that are uncontrolled despite inhaled corticosteroids have a distinct breathprint (the pacman2 study)

2015 ◽  
Vol 5 (S2) ◽  
Author(s):  
Susanne Vijverberg ◽  
Paul Brinkman ◽  
Jan Raaijmakers ◽  
Kors van der Ent ◽  
Peter Sterk ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Asthmatic Children

scholarly journals Adrenal Function and Linear Growth in Asthmatic Children Treated with High Dose Inhaled Corticosteroids (ICS)

1998 ◽  
Vol 44 (3) ◽  
pp. 455-455
Author(s):  
C Dunlop ◽  
J McNaboe ◽  
H J Steen ◽  
D Carson ◽  
B Sheridan ◽  
...  
Keyword(s):  
Linear Growth ◽  
Inhaled Corticosteroids ◽  
Adrenal Function ◽  
High Dose ◽  
Asthmatic Children

Inhaled Budesonide vis-à-vis Inhaled Mometasone in Chinese Children with Mild Persistent Asthma: A Single-Center, Retrospective Study

Pharmacology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Pei Gao ◽  
Ying Ding ◽  
Bingru Yin ◽  
Haoxiang Gu
Keyword(s):  
Retrospective Study ◽  
Asthma Exacerbation ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Forced Expiratory Volume ◽  
Single Center ◽  
Level Of Evidence ◽  
Asthmatic Children ◽  
Technical Efficacy ◽  
Mild Persistent Asthma

<b><i>Introduction:</i></b> A very limited option of inhaled corticosteroids (ICSs) is approved for pediatric use in China because in children the use of ICSs for long periods is associated with dose-dependent growth reduction. Due to the lack of consensus on which is the best ICS-based treatment option to manage mild persistent asthma in children, the present study was performed to evaluate the efficacy and safety of budesonide (BUD)-based therapy vis-à-vis mometasone-based therapy in children with mild persistent asthma. <b><i>Methods:</i></b> A single-center, retrospective study was conducted in asthmatic children aged between 6 and 11 years. BUD and mometasone furoate (MF) were administered as per the approved dosing regimen using pressurized metered-dose inhalers via oral inhalation route for a period of 12 weeks. The study outcome was assessed in terms of the forced expiratory volume in 1 s (FEV<sub>1</sub>), symptom scores, and nonoccurrence of side effects. <b><i>Results:</i></b> Among the 77 asthmatic children, 71 completed the study treatment and were used in carrying out the analysis. The improvement of spirometric parameters like FEV<sub>1</sub>, Tiffeneau-Pinelli index (FEV1/forced vital capacity [FVC]), and peak expiratory flow (PEF) values observed in the MF cohort was significantly greater than those of the BUD cohort (<i>p</i> &#x3c; 0.05 for all). An increase of approximately 12%/child was observed for FEV<sub>1</sub>/FVC ratios for the BUD cohort and MF cohorts. After the 12-week study, the PEF<sub>m</sub> and PEF<sub>e</sub> values increased to about 50 L/min/child for the BUD cohort and about 98 L/min/child for the MF cohort. During the study, no asthma exacerbation event was observed in the MF cohort, whereas 1 child in the BUD cohort had asthma exacerbation in week 4. The use of rescue medication during the study was required for 16.2 and 6% of children, respectively, for BUD and MF cohorts. Owing to low dosing frequency, MF could provide a better treatment approach than BUD due to improved patient compliance. <b><i>Conclusions:</i></b> Although both drugs showed improvement in the quality of life of asthmatic children with manageable treatment-emergent adverse effects, the improvement was augmented in MF-treated children. <b><i>Level of Evidence:</i></b> The level of evidence was III. <b><i>Technical Efficacy Stage:</i></b> The technical efficacy stage was 4.

Effect of Inhaled Corticosteroids on Growth and Puberty in Egyptian Asthmatic Children and Adolescents

2010 ◽  
Vol 13 (20) ◽  
pp. 977-984 ◽  
Author(s):  
Zainab A. El-Sayed ◽  
Rasha T. Hamza ◽  
Nasr El-Din A. Sayed ◽  
Nermine H. Mahmoud
Keyword(s):  
Children And Adolescents ◽  
Inhaled Corticosteroids ◽  
Asthmatic Children

scholarly journals Spirometry monitoring in asthmatic children in Lombardy Region, Italy

2018 ◽  
Vol 2 (1) ◽  
pp. e000334
Author(s):  
Pietro Casartelli ◽  
Antonio Clavenna ◽  
Massimo Cartabia ◽  
Angela Bortolotti ◽  
Ida Fortino ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Inhaled Corticosteroids ◽  
Drug Prescription ◽  
Administrative Databases ◽  
Function Evaluation ◽  
Local Health ◽  
Local Health Unit ◽  
Lombardy Region ◽  
Asthmatic Children ◽  
Antiasthmatic Drug

ObjectivesTo evaluate the diagnostic and therapeutic approaches in a cohort of asthmatic children before and after starting drug therapy.MethodsData were retrieved from administrative databases of the Lombardy Region. The study population was composed of 78 184 children born in the Lombardy Region in 2002 and followed until their 10th birthday.Children with at least one antiasthmatic drug prescription per year (with the exclusion of nebulised suspension/solution formulations) in 2 consecutive years and at least one antiasthmatic drug prescription after the fifth birthday were identified as potential asthmatics (PA).Each PA was monitored for a period starting from 12 months before and ending 24 months after the first prescription (index prescription, IP). During the monitoring period antiasthmatic drug prescriptions were analysed, as well as spirometry and/or specialist visits.ResultsA total of 59 975 children (76.7%) received ≥1 prescription of antiasthmatic drugs in their first 10 years of life, and 4475 (5.7%) were identified as PAs. In all, 24% of PAs started with short-acting β2-agonists (SABA), 23% with inhaled corticosteroids (ICS) and 20% with SABA+ICS.A total of 33% of PAs had at least one prescription for specialist visit/spirometry: 11% before and 28% after the IP. The factors associated with a greater likelihood of receiving visit/spirometry prescriptions were local health unit of residence, age and high use of asthma drugs.ConclusionsDespite international guideline recommendations, spirometry monitoring is still underused in asthmatic children, even in subjects who initiated pharmacological treatment and therefore need an airway function evaluation. Moreover, the choice of drug therapy appears not always rational, since one out of four children were commenced on ICS as monotherapy.

Influence of inhaled corticosteroids on pubertal growth and final height in asthmatic children

2016 ◽  
Vol 27 (5) ◽  
pp. 499-506 ◽  
Author(s):  
Chiara De Leonibus ◽  
Marina Attanasi ◽  
Zane Roze ◽  
Benedetta Martin ◽  
Maria Loredana Marcovecchio ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Final Height ◽  
Asthmatic Children ◽  
Pubertal Growth

scholarly journals Relationship between exhaled nitric oxide levels and compliance with inhaled corticosteroids in asthmatic children

2006 ◽  
Vol 100 (9) ◽  
pp. 1512-1517 ◽  
Author(s):  
Maria Katsara ◽  
Deidrie Donnelly ◽  
Shaique Iqbal ◽  
Tracy Elliott ◽  
Mark L. Everard
Keyword(s):  
Nitric Oxide ◽  
Inhaled Corticosteroids ◽  
Exhaled Nitric Oxide ◽  
Asthmatic Children

scholarly journals Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children

2017 ◽  
Vol 50 (6) ◽  
pp. 1700910 ◽  
Author(s):  
Anja Jochmann ◽  
Luca Artusio ◽  
Angela Jamalzadeh ◽  
Prasad Nagakumar ◽  
Edgar Delgado-Eckert ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Electronic Monitoring ◽  
Inhaled Corticosteroids ◽  
Good Control ◽  
Clinical Parameter ◽  
Poor Adherence ◽  
Poor Control ◽  
Good Adherence ◽  
Asthmatic Children ◽  
Monitoring Devices

International guidelines recommend that severe asthma can only be diagnosed after contributory factors, including adherence, have been addressed. Accurate assessment of adherence is difficult in clinical practice. We hypothesised that electronic monitoring in children would identify nonadherence, thus delineating the small number with true severe asthma.Asthmatic children already prescribed inhaled corticosteroids were prospectively recruited and persistence of adherence assessed using electronic monitoring devices. Spirometry, airway inflammation and asthma control were measured at the start and end of the monitoring period.93 children (62 male; median age 12.4 years) were monitored for a median of 92 days. Median (range) monitored adherence was 74% (21–99%). We identified four groups: 1) good adherence during monitoring with improved control, 24% (likely previous poor adherence); 2) good adherence with poor control, 18% (severe therapy-resistant asthma); 3) poor adherence with good control, 26% (likely overtreated); and 4) poor adherence with poor control, 32%. No clinical parameter prior to monitoring distinguished these groups.Electronic monitoring is a useful tool for identifying children in whom a step up in treatment is indicated. Different approaches are needed in those who are controlled when adherent or who are nonadherent. Electronic monitoring is essential in a paediatric severe asthma clinic.

scholarly journals EVALUATION OF INDUCED SPUTUM CYTOLOGY IN ASTHMATIC CHILDREN

2021 ◽  
Author(s):  
Debora Carla Chong-Silva ◽  
Adriana Nascimento ◽  
Roberta Cunha ◽  
Elessandra Bitencourt ◽  
Leticia Botelho ◽  
...  
Keyword(s):  
Asthma Control ◽  
Inhaled Corticosteroids ◽  
Pulmonary Function Tests ◽  
Sputum Cytology ◽  
Asthma Control Test ◽  
Sputum Induction ◽  
Hypertonic Saline Solution ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Children With Asthma

Objective: To evaluate the viability of sputum cytology in asthmatic children, recognizing inflammatory patterns and correlating them with clinical, epidemiological and functional variables of the disease. Methods: This was a cross-sectional and observational study of children with asthma who underwent sputum induction through increasing concentrations of nebulized hypertonic saline solution from 3% to 7%. The samples were processed according to the technique developed by Pizzichini et al. and the cytological pattern classified as pauci-granulocytic, neutrophilic, eosinophilic and mixed. Samples with cell viability> 50% were considered adequate. Asthma control was assessed using the asthma control test (ACT). Results: Seventy-nine children performed sputum induction. Thirty-three samples were excluded because they were not viable for analysis, resulting in 46 samples. The children’s average age was 9.4 (± 3) years. There was a predominance of eosinophilic (25/46, 54.3%), followed by mixed (13/46, 28.3%), pauci-granulocytic (7/46, 15.2%) and neutrophilic (1/46, 2.2%) pattern. Sixty-three percent of the children had severe asthma and 84.7% were treated with inhaled corticosteroids. The ACT showed that 25 (56.8%) patients had the disease under control. Forty-five children (97.8%) underwent pulmonary function tests (spirometry) and in 13 cases (28.9%) an obstructive ventilatory defect was found. Conclusions: The eosinophilic profile was predominant in the assessed asthmatic children. Non-eosinophilic phenotypes were found, but less frequently. There was no difference between the clinical variables and the sputum profile in this study group. Sputum induction in children with asthma is feasible and safe and can contribute to a specific and personalized approach to the disease.

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