scholarly journals In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome

2013 ◽  
Vol 15 (5) ◽  
pp. R114 ◽  
Author(s):  
Roman Volchenkov ◽  
Johan G Brun ◽  
Roland Jonsson ◽  
Silke Appel
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Tolerogenic Dendritic Cells ◽  
Sjögren‘S Syndrome

scholarly journals DENDRITIC CELLS IN PRIMARY SJOGREN'S SYNDROME

2019 ◽  
Author(s):  
WANESSA SIQUEIRA CAVALCANTE ◽  
SHEYLA BATISTA BOLOGNA LOPES ◽  
SILVIA VANESSA LOURENCO ◽  
LUIZ FERNANDO FERRAZ DA SILVA ◽  
MARCELLO MENTA SIMONSEN NICO
Keyword(s):  
Dendritic Cells ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Immune responses after influenza vaccination in patients of primary Sjögren’s syndrome

Rheumatology ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 224-230
Author(s):  
Xingyu Zhou ◽  
Yisi Liu ◽  
Yuebo Jin ◽  
Yifan Wang ◽  
Miao Miao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Influenza Vaccination ◽  
Th17 Cells ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Th1 Cells ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Abstract Objectives Influenza vaccination is effective in preventing infections in most people. This study aimed to assess the changes of immune responses in primary Sjögren’s Syndrome (pSS) patients after influenza vaccination and determine the safety of influenza vaccination. Methods A total of 17 patients with pSS and 16 healthy controls (HCs) were included. Peripheral mononuclear cells were analysed by flow cytometry. Vaccine-specific antibodies were determined by ELISA. Clinical features and serological responses were monitored. Results The percentages of T follicular helper cell (Tfh) were significantly elevated in HCs after vaccination (P=0.0005), while no significant differences in the levels of Tfh in pSS patients were identified (P=0.1748). The proportions of Th2 cells were significantly decreased after vaccination in both pSS patients and HCs (P<0.05). In contrast, the percentages of Th1 cells and Th17 cells were significantly increased after vaccination in pSS patients (P<0.05), while no significant differences in the percentages of Th1 and Th17 cells were identified in HCs (P>0.05), although a trend towards higher levels of Th1 cells was observed (P=0.0830). No significant changes in the proportions of memory B cells and plasmablasts were observed after vaccination. Patients with pSS developed higher levels of vaccine-specific IgGs compared with HCs (P=0.001). No significant changes in disease manifestations and laboratory parameters were observed after vaccination. No increased vaccination related adverse effect was observed in pSS. Conclusion Our findings suggest the feasibility of applying influenza vaccines to patients with pSS, raising awareness for vaccination among the rheumatology community and involved healthcare professionals.

Sign in / Sign up

Export Citation Format

Share Document