scholarly journals Influenza A (H1N1): the first hit for transfusion-related acute lung injury?

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P114
Author(s):  
F Piza ◽  
F Carvalho ◽  
H Li ◽  
T Crochemore ◽  
R Rodrigues
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A ◽  
Influenza A H1n1

scholarly journals IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

Cell Research ◽  
2011 ◽  
Vol 22 (3) ◽  
pp. 528-538 ◽  
Author(s):  
Chenggang Li ◽  
Penghui Yang ◽  
Yang Sun ◽  
Taisheng Li ◽  
Chen Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1

scholarly journals Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e44110 ◽  
Author(s):  
Chenggang Li ◽  
Penghui Yang ◽  
Yanli Zhang ◽  
Yang Sun ◽  
Wei Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A ◽  
H1n1 Virus ◽  
Corticosteroid Treatment ◽  
Influenza A H1n1

The effect of aminoguanidine on acute lung injury induced by influenza A/H1N1/PDM09

2020 ◽  
Vol 20 (2) ◽  
pp. 33-44
Author(s):  
Andrei G. Aleksandrov ◽  
Tatiana N. Savateeva-Lyubimova ◽  
Kira I. Stosman ◽  
Arman A. Muzhikyan ◽  
Konstantin V. Sivak
Keyword(s):  
Influenza Virus ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A ◽  
Structural Changes ◽  
Saturation Index ◽  
Influenza Infection ◽  
Proinflammatory Response ◽  
Influenza Virus A ◽  
Influenza A H1n1

Background. Acute lung injury is one of severe course of influenza infection with mortality up to 40% of patients, despite on etiological and pathogenetic therapy. The aim of the article to study of the effects of aminoguanidine on correcting on acute lung injury induced by influenza virus A/California/7/09MA (mouse-adapted) (H1N1)pdm09, collection Smorodintsev Research Institute of Influenza. Materials and methods. The study was performed on 95 outbred female mice. The mouse-adapted pandemic influenza virus A/California/7/09MA (H1N1)pdm09 was used for modeling viral infection at a dose of 1 LD50. The mortality was analysed. Levels of advanced glycation end-products (AGEs), proinflammatory cytokines in lung; saturation index and leukocytes marker parameters in blood; pathological and histological studies of lung were performed on 4 and 7 days post infection. Results. Aminoguanidine led to 2-fold decrease in mortality in mice with virus-induced acute lung injury; significantly suppressed the growth of AGEs and proinflammatory cytokine levels in lung; reduced decrease of saturation index and hematological inflammatory markers; decreased level of inflammatory injury in lung tissue. Conclusion. Aminoguanidine relieved virus-induced acute lung injury in mice. These AGEs inhibitor reduced the proinflammatory response and structural changes in respiratory tract epithelial cells induced by reactive carbonyl compounds on cell membrane.

scholarly journals Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus

2010 ◽  
Vol 49 (5) ◽  
pp. 427-430 ◽  
Author(s):  
Toshiki Yokoyama ◽  
Kenji Tsushima ◽  
Atsuhito Ushiki ◽  
Nobumitsu Kobayashi ◽  
Kazuhisa Urushihata ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A ◽  
H1n1 Virus ◽  
Alveolar Hemorrhage ◽  
Influenza A H1n1

scholarly journals Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

Cell Research ◽  
2013 ◽  
Vol 23 (4) ◽  
pp. 577-580 ◽  
Author(s):  
Wei Wang ◽  
Penghui Yang ◽  
Ying Zhong ◽  
Zhongpeng Zhao ◽  
Li Xing ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1

scholarly journals Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice

Dose-Response ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 155932582110113
Author(s):  
Rufeng Lu ◽  
Yueguo Wu ◽  
Honggang Guo ◽  
Zhuoyi Zhang ◽  
Yuzhou He
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Virus ◽  
Antiviral Agents ◽  
Toll Like Receptor ◽  
Virus Infections ◽  
Toll Like Receptor 4 ◽  
Inflammatory Cytokine Production

Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.

scholarly journals Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection

mSystems ◽  
2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Cong Zhang ◽  
Yuqing Zhang ◽  
Yuhao Qin ◽  
Qingchao Zhang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lung Injury ◽  
Rna Interference ◽  
Virus Infection ◽  
Lung Injury ◽  
Cell Viability ◽  
Influenza A ◽  
H5n1 Virus ◽  
H5n1 Infection ◽  
Rnai Screening

ABSTRACT Due to the limitations of effective treatments, avian influenza A H5N1 virus is the most lethal influenza virus strain that causes severe acute lung injury (ALI). To develop effective drugs ameliorating H5N1-induced ALI, we explore an RNA interference (RNAi) screening method to monitor changes in cell death induced by H5N1 infection. We performed RNAi screening on 19,424 genes in A549 lung epithelial cells and examined cell death induced by H5N1 infection. These screens identified 1,137 host genes for which knockdown altered cell viability by over 20%. DrugBank searches of these 1,137 host genes identified 146 validated druggable target genes with 372 drug candidates. We obtained 104 commercially available drugs with 65 validated target genes and examined their improvement of cell viability following H5N1 infection. We identified 28 drugs that could significantly recover cell viability following H5N1 infection and tested 10 in an H5N1-induced-ALI mouse model. The neurological drug ifenprodil and the anticancer drug flavopiridol markedly decreased leukocyte infiltration and lung injury scores in infected mouse lungs, significantly ameliorated edema in infected mouse lung tissues, and significantly improved the survival of H5N1-infected mice. Ifenprodil is an antagonist of the N-methyl-d-aspartate (NMDA) receptor, which is linked to inflammation and lung injury. Flavopiridol is an inhibitor of cyclin-dependent kinase 4 (CDK4), which is linked to leukocyte migration and lung injury. These results suggest that ifenprodil and flavopiridol represent novel remedies against potential H5N1 epidemics in addition to their proven indications. Furthermore, our strategy for identifying repurposable drugs could be a general approach for other diseases. IMPORTANCE Drug repurposing is a quick and economical strategy for developing new therapies with approved drugs. H5N1 is a highly pathogenic avian influenza virus subtype that can cause severe acute lung injury (ALI) and a high mortality rate due to limited treatments. The use of RNA interference (RNAi) is a reliable approach to identify essential genes in diseases. In most genomewide RNAi screenings, virus replication is the readout of interference. Since H5N1 virus infection could induce significant cell death and the percentage of cell death is associated with virus lethality, we designed a genomewide RNAi screening method to identify repurposable drugs against H5N1 virus with cell death as the readout. We discovered that the neurological drug ifenprodil and the anticancer drug flavopiridol could effectively ameliorate murine ALI after influenza A H5N1 virus infection, suggesting that they might be novel remedies for H5N1 virus-induced ALI in addition to the traditional indications.

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