scholarly journals Early initiation of eculizumab treatment in patients with atypical haemolytic uraemic syndrome improves long-term outcomes: a pooled analysis of clinical trials

Critical Care ◽  
2015 ◽  
Vol 19 (Suppl 1) ◽  
pp. P330
Author(s):  
J Walle ◽  
Y Delmas ◽  
G Ardissino ◽  
J Wang ◽  
J Kincaid ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Haemolytic Uraemic Syndrome ◽  
Pooled Analysis ◽  
Early Initiation ◽  
Long Term Outcomes ◽  
Atypical Haemolytic Uraemic Syndrome

The long-term outcomes of atypical haemolytic uraemic syndrome: a national surveillance study

2016 ◽  
Vol 101 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Anne M Durkan ◽  
Siah Kim ◽  
Jonathan Craig ◽  
Elizabeth Elliott
Keyword(s):  
Haemolytic Uraemic Syndrome ◽  
Graft Loss ◽  
Neurological Complications ◽  
Initial Presentation ◽  
Cardiac Complications ◽  
Long Term Outcomes ◽  
Mortality And Morbidity ◽  
Atypical Haemolytic Uraemic Syndrome

BackgroundAtypical haemolytic uraemic syndrome (aHUS) accounts for ∼10% of all cases of HUS and is often due to complement dysregulation. The short-term outcomes for this disease are established, but there are limited long-term data. The long-term outcomes of a comprehensive nationwide cohort of children with aHUS are presented here.MethodsThe Australian Paediatric Surveillance Unit prospectively collected data on all cases of HUS in children seen by paediatricians between 1994 and 2001. Patients with aHUS were followed-up with a written questionnaire to the treating clinician at 1 year and again before transition to adult services or at last known follow-up.ResultsThere were 146 reported cases of HUS, of which 14 were aHUS. Ten children required dialysis at first presentation, including two who died and three who did not recover renal function. The disease was relapsing in all but one who survived the presenting episode, with most relapses occurring in the first 12 months. At 1 year, one child was lost to follow-up. Nine of the remaining 11 patients were dialysis dependent. Thirteen kidneys were transplanted into eight children. There was disease recurrence in eight kidneys, which resulted in graft loss in seven. There were three further deaths 1.7, 6.7 and 16.1 years after the initial presentation. Five children developed neurological complications and two had cardiac complications, largely at the time of onset of the disease.ConclusionsaHUS is a rare but devastating disease with very high mortality and morbidity that extends beyond the initial presentation period.

scholarly journals Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data

2019 ◽  
Vol 18 (4) ◽  
pp. 348-356 ◽  
Author(s):  
Thomas G Brott ◽  
David Calvet ◽  
George Howard ◽  
John Gregson ◽  
Ale Algra ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
Individual Patient Data ◽  
Pooled Analysis ◽  
Patient Data ◽  
Long Term Outcomes ◽  
Symptomatic Carotid ◽  
Symptomatic Carotid Stenosis

scholarly journals Long-term outcomes from the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study

2015 ◽  
Vol 150 ◽  
pp. 112-119 ◽  
Author(s):  
Roger D. Weiss ◽  
Jennifer Sharpe Potter ◽  
Margaret L. Griffin ◽  
Scott E. Provost ◽  
Garrett M. Fitzmaurice ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Drug Abuse ◽  
Addiction Treatment ◽  
Opioid Addiction ◽  
Prescription Opioid ◽  
Drug Abuse Treatment ◽  
Long Term Outcomes ◽  
National Drug ◽  
Abuse Treatment
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