Randomised Double Blinded Placebo Controlled Trial of Magnesium Sulphate in Reducing Length of Hospital Stay In Patients Undergoing Elective Large Bowel Resection

Abstract Background To investigate the effects of enhanced recovery after surgery (ERAS) in patients undergoing gynecologic surgery on length of hospital stay, pain management, and complication rate. Results The length of hospital stay was reduced in ERAS groups when compared with the control groups (3.46 days vs 2.28 days; P < 0.0001; CI − 1.5767 to − 0.7833 for laparotomy groups and 2.18 vs 1.76 days; P = 0.0115; CI − 0.7439 to − 0.0961 for laparoscopy groups respectively). Intraoperative fluid use was reduced in both ERAS groups compared to the two control groups (934 ± 245 ml and 832 ± 197 ml vs 1747 ± 257 ml and 1459 ± 304 respectively; P < 0.0001) and postoperative fluid use was also less in the ERAS groups compared to the control groups (1606 ± 607 ml and 1210 ± 324 ml vs 2682 ± 396 ml and 1469 ± 315 ml respectively; P < 0.0001). Pain score using visual analog scale (VAS) on postoperative day 0 was 4.8 ± 1.4 and 4.1 ± 1.2 (P = 0.0066) for both laparotomy control and ERAS groups respectively, while in the laparoscopy groups, VAS was 3.8 ± 1.1 and 3.2 ± 0.9 (P = 0.0024) in control and ERAS groups respectively. Conclusion Implementation of ERAS protocols in gynecologic surgery was associated with significant reduction in length of hospital stay, associated with decrease intravenous fluids used and comparable pain control without increase in complication rates.

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Suture-Line Neoplastic Recurrence following Large-Bowel Resection

Australian and New Zealand Journal of Surgery ◽

10.1111/j.1445-2197.1968.tb06255.x ◽

1971 ◽

Vol 41 (1) ◽

pp. 44-46 ◽

Cited By ~ 22

Author(s):

K. J. Hardy ◽

A. M. Cuthbertson ◽

E. S. R. Hughes

Keyword(s):

Large Bowel ◽

Bowel Resection ◽

Suture Line ◽

Large Bowel Resection

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The role of bovine colostrum on recovery time and length of hospital stay of acute diarrhea in infants and children: a double-blind randomized controlled trial

Paediatrica Indonesiana ◽

10.14238/pi46.3.2006.127-33 ◽

2016 ◽

Vol 46 (3) ◽

pp. 127

Author(s):

IGN Suwarba ◽

Sudaryat S ◽

Hendra S ◽

IKG Suandi ◽

Raka Widiana

Keyword(s):

Hospital Stay ◽

Acute Diarrhea ◽

Recovery Time ◽

Controlled Trial ◽

Length Of Hospital Stay ◽

Bovine Colostrum ◽

Mean Difference ◽

Infants And Children ◽

Double Blind ◽

Defecation Frequency

Background WHO standard treatment for acute diarrhea remainsunsatisfying to the parents of acute diarrhea patients, particularlythe need of medical treatment. Bovine colostrum contains immuneand growth factors that is thought able to neutralize some agentscausing acute diarrhea in infants and children.Objective To evaluate the efficacy of bovine colostrum as adju-vant therapy on recovery time and length of hospital stay for acutediarrhea in infants and children.Methods A double-blind randomized controlled trial was conductedon infants and children with acute diarrhea admitted to SanglahHospital. Treatment group received standard therapy with bovinecolostrums and control group received standard therapy plus pla-cebo. The primary outcomes were achievement of recovery timeand length of hospital stay. Recovery time was determined by thenumber of days needed to achieve defecation frequency <3 times/day and needed to achieve normal stool consistency.Results Seventy infants and children were enrolled. The treatmentgroup significantly achieved recovery time earlier than the control groupin regard to the time of achieving defecation frequency to <3 times/day [2.31 (0.76) vs 3.34 (1.45); mean difference of -1.03; P= 0.001; CI95% -1.58;-0.48] and normal stool consistency [2.40 (0.77) vs 3.43(1.48); mean difference of -1.03; P = 0.001; CI 95% -1.59;-0.46]. Lengthof hospital stay was shorter in the treatment group than the controlgroup [2.89 (0.78) vs 3.94 (1.53); mean difference of -1.05; P= 0.001;CI 95% (-1.3;-0.7)]. No significant difference was found in mean ofbody weight recovery in two groups [0.47 (0.16) vs 0.49 (0.20); meandifference of -0.03; P=0.556; CI 95%: -0.11;0.06]. Age, nutritionalstatus, breastfeeding, and diarrhea before admission did not influ-ence the study outcome.Conclusion Bovine colostrums as an adjuvant in standard therapyfor acute diarrhea in infants and children is effective in regard toachieve earlier recovery time and shorter length of hospital stay

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Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial

The Lancet ◽

10.1016/s0140-6736(11)60607-7 ◽

2011 ◽

Vol 377 (9782) ◽

pp. 2023-2030 ◽

Cited By ~ 186

Author(s):

Sabine CA Meijvis ◽

Hans Hardeman ◽

Hilde HF Remmelts ◽

Rik Heijligenberg ◽

Ger T Rijkers ◽

...

Keyword(s):

Hospital Stay ◽

Controlled Trial ◽

Length Of Hospital Stay ◽

Community Acquired Pneumonia ◽

Double Blind ◽

Double Blind Placebo

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Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynecological malignancies: a randomized controlled trial

10.21203/rs.2.12316/v1 ◽

2019 ◽

Cited By ~ 1

Author(s):

Jiawei Chen ◽

Lin Tian ◽

Le Zhang ◽

Jianying Hu ◽

Shaoqiang Huang ◽

...

Keyword(s):

Laparoscopic Surgery ◽

Postoperative Pain ◽

Hospital Stay ◽

Postoperative Nausea ◽

Serum Gastrin ◽

Controlled Trial ◽

Length Of Hospital Stay ◽

First Passage ◽

Gynecological Malignancies ◽

To Receive

Abstract Background The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies. Methods A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups. Results The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S. Conclusions Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain.

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