defecation frequency
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Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1147
Author(s):  
Ju-Ryun Na ◽  
Ki Hoon Lee ◽  
Eun Kim ◽  
Kwontack Hwang ◽  
Chang-Su Na ◽  
...  

Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract of Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials and Methods: Animal studies were conducted with low-fiber diet-induced and loperamide-induced constipation animal models, and isolated colons were used in ex vivo analysis to determine the changes in colonic motility caused by D. morbiferus H. Lév. leaf extract (DPL). Results: The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea. The laxative effect of DPL was confirmed to improve the charcoal excretion time upon DPL treatment in a low-fiber diet or loperamide-induced constipation model through gastrointestinal (GI) motility evaluation using the charcoal meal test. In addition, when DPL was administered to RAW264.7 cells and loperamide-induced constipation model rats, the production of prostaglandin E2 (PGE2) increased significantly in cells and tissue. Furthermore, DPL dose-dependently stimulated the spontaneous contractile amplitude and frequency of the isolated rat colon. Conclusion: Although our study did not provide information on the acute or chronic toxicity of DPL, our results demonstrated that DPL can effectively promote defecation frequency and rat colon contraction, providing scientific evidence to support the use of DPL as a therapeutic application. However, further toxicity studies of DPL are needed prior to the initiation of clinical trials and clinical applications.


2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 337-337
Author(s):  
Hee S Kim ◽  
Charles G Aldrich

Abstract Increasing the amount of liquid fat to the ration during extrusion can negatively affect product density and product expansion. Ingredients, like whole soybeans (WSB), which are high in fat may aid increased energy density while avoiding production issues. In a preliminary extrusion project, the effects on the process of foods were evaluated, followed by animal evaluation. The objective of this study was to determine the effect of dehulled WSB on nutrient digestibility and stool quality by dogs. Experimental diets were extruded with 0%, 10%, 20%, and 30% WSB (WSB0, WSB10, WSB20, and WSB30, respectively). Seven castrated male and three spayed female Beagles of similar age (6.25 ± 0.452 years) were individually housed and fed the experimental diets. The study was designed as replicated 4 × 4 Latin square where dogs were allowed 9-d adaptation followed by 5-d total fecal collection for each period. Titanium dioxide was added to all diets (0.4%) to serve as an indigestible dietary marker to determine apparent total tract digestibility (ATTD). Least-square means of fecal parameters and ATTD were analyzed with a single degree of freedom contrasts and significance at α = 0.05. There was no difference among treatments for food intake or fecal scores. However, there were linear increases (P < 0.05) in DM fecal output, as is fecal output, fecal moisture, and defecation frequency stools/day as WSB increased in the diets. Apparent total tract digestibility of dry matter, crude protein, acid hydrolyzed ether extract, and gross energy decreased linearly as dogs were fed increasing levels of WSB in the diets (P < 0.05). In conclusion, additional thermal processing before extrusion may improve nutrient digestibility, although stool quality was not affected by the inclusion of WSB.


2021 ◽  
Vol 7 (5) ◽  
pp. 1551-1557
Author(s):  
Huang Yuanqin ◽  
Li Xiaoqian ◽  
he Huizhen ◽  
Li Lin ◽  
Xu Hui

To investigate the efficacy of Shenqi Runchang Tongbian Decoction in the treatment of children with constipation and its effect on the clinical symptoms of children. Methods: From January 2016 to January 2020, 100 patients with constipation were randomly divided into two groups. The control group was treated with lactulose oral solution, and the study group was treated with Shenqi Runchang Tongbian Decoction. Both groups were administered with drugs for 14 days, and the two groups were followed up on the 28th day. The effectiveness of the two groups was compared before treatment and during follow-up. The changes of various symptom scores were compared before treatment, after treatment and during follow-up, and the changes of primary symptom score, secondary symptom score and total score were compared before treatment, after treatment and during follow-up. Results: After treatment, the effectiveness of the study group was higher than that of the control group at follow-up (P <0.05). After treatment and during the follow-up, the scores of facial color, lips, sleep, urination, hand-foot-heart-chest, appetite, halitosis, abdominal distension and abdominal pain, defecation duration, defecation difficulty, defecation frequency and stool property of the two groups were lower than those before treatment (P < 0.05). There was no significant difference in the scores of facial color, sleep, urination and hand-foot-heart-chest symptoms before and after treatment of the control group and the study group (P > 0.05). There was no significant difference in the scores of facial color, lips, sleep, urination and hand-foot-heart-chest symptoms before treatment and during follow-up between the control group and the study group (P > 0.05). The scores of lip symptoms after treatment in the study group were lower than those in the control group (P < 0.05). The scores of appetites, halitosis, abdominal distension and abdominal pain, defecation duration, defecation difficulty, defecation frequency, stool property after treatment and during follow-up in the study group were lower than those in the control group (P <0.05). The total score, the secondary symptom score and the primary symptom score of the two groups before treatment and during follow-up were lower than those before treatment (P < 0.05). The total score, the secondary symptom score and the primary symptom score in the study group were lower than those in the control group after treatment and during follow-up (P < 0.05). Conclusion: The treatment of children with constipation with Shenqi Runchang Tongbian Decoction can improve the secondary symptoms and primary symptoms of children and improve the comprehensive curative effect, especially in the aspects of improving appetite, halitosis, abdominal distension and abdominal pain, defecation duration, defecation difficulty, defecation frequency and stool property. It can effectively enhance the gastrointestinal function and promote the rehabilitation of children. It is worthy of being popularized in clinical practice.


2021 ◽  
Vol 7 (9) ◽  
pp. 782
Author(s):  
Atsushi Kurahashi ◽  
Toshihiko Enomoto ◽  
Yoshifumi Oguro ◽  
Ayana Kojima-Nakamura ◽  
Kazuya Kodaira ◽  
...  

Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The Koji amazake had 302 ± 15.5 mg/118 g of A. oryzae cells, which was not in the placebo. Compared with the placebo group, the koji amazake group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of koji amazake did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of Blautia and significantly increased that of Bacteroides at 3 weeks. Therefore, koji amazake intake improved defecation frequency, and A. oryzae cells played potentially important roles as functional ingredients.


2021 ◽  
Vol 12 ◽  
Author(s):  
Yulin Lu ◽  
Jingjing Huang ◽  
Yao Zhang ◽  
Zitong Huang ◽  
Weiming Yan ◽  
...  

The etiology of diarrhea-predominant irritable bowel syndrome (IBS-D) is complicated and closely related to neurotransmission in the gastrointestinal (GI) tract. Developing new strategies for treating this disease is a major challenge for IBS-D research. Berberine hydrochloride (BBH), the derivative of berberine, is a herbal constituent used to treat IBS. Previous studies have shown that BBH has potential anti-inflammatory, antibacterial, analgesic, and antidiarrheal effects and a wide range of biological activities, especially in regulating the release of some neurotransmitters. A modified IBS-D rat model induced by chronic restraint stress was used in all experiments to study the effects of BBH on the GI tract. This study measured the abdominal withdrawal reflex (AWR) response to graded colorectal distention (CRD; 20, 40, 60, and 80 mmHg) and observed the fecal areas of stress-induced IBS-D model. Experiments were conducted using organ bath techniques, which were performed in vitro using strips of colonic longitudinal smooth muscle. Inhibitory and excitatory neurotransmitter agents were added to each organ bath to observe contractile responses on the strips and the treatment effect exerted by BBH. The IBS-D rat model was successfully induced by chronic restraint stress, which resulted in an increased defecation frequency and visceral hypersensitivity similar to that of humans. BBH could reduce 4-h fecal areas and AWR response to CRD in IBS-D. The stress-induced IBS-D model showed upregulated colonic mRNA expression levels of 5-hydroxytryptamine-3A receptor and downregulated expression levels of neuronal nitric oxide synthase. Meanwhile, BBH could reverse this outcome. The responses of substances that regulate the contraction induced by related neurotransmission in the longitudinal smooth muscle of IBS-D colon (including the agonist of acetylcholine, carbachol; NOS inhibitor, L-NAME; and P2Y1 receptor antagonist, MRS2500) can be inhibited by BBH. In summary, BBH promotes defecation frequency and visceral hypersensitivity in IBS-D and exerts inhibitory effects on contractile responses in colonic longitudinal smooth muscle. Thus, BBH may represent a new therapeutic approach for treating IBS-D.


2021 ◽  
Vol 9 ◽  
Author(s):  
Zhi Liu ◽  
Li Gang ◽  
Ma Yunwei ◽  
Ling Lin

Background: Functional constipation in children is a common disease that causes a psychological burden on infants and young children across the world. It will greatly affect infant quality of life in early childhood and even affect their psychological and physical health. At present, infant functional constipation is treated with western drugs alone, but this can produce drug dependency. In recent years, Traditional Chinese Medicine (TCM) infant massage has been used as a complementary and alternative therapy, and its effectiveness and safety have been proven, attracting the attention of numerous researchers.Objective: Our study aimed to compare the influence of infant massage intervention on defecation frequency and consistency, determine the effectiveness, and safety of infant massage in the treatment of infant functional constipation, and obtain high-quality clinical evidence.Methods: Based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement, inclusion, and exclusion criteria were formulated. Randomized controlled trials (RCTs) on TCM infant massage for the treatment of infant functional constipation were found following a search of four mainstream medical databases. RCTs found to meet the study's requirement were included; data information was then extracted, and the quality was assessed using the Cochrane bias risk assessment tool. Through RevMan software, a meta-analysis was carried out for overall effective rate, stool form, defecation frequency, defecation difficulty, and constipation symptom scoring index. The relative risk (RR) and 95% confidence interval (95% CI) were calculated, heterogeneity was tested and its source was found, and publication bias was assessed through the Egger's and Begg's tests and by means of funnel plots.Results: A total of 23 RCTs and 2,005 patients were included. The results of the meta-analysis showed that compared to drug therapy alone, TCM infant massage had a superior effect on the treatment of infant functional constipation. This difference was statistically significant (p &lt; 0.05) and evaluated according to the overall effective rate (RR = 1.25; 95% CI = 1.17, 1.33), defecation frequency [mean difference (MD) = −0.72; 95% CI = −0.80, −0.65], and constipation symptom score (MD = −0.81; 95% CI = −1.20, −0.43), showing that TCM infant massage is indeed superior to drug therapy alone in the treatment of infant functional constipation. TCM infant massage was found to be equivalent to drug therapy alone in terms of the stool form score [−0.30 (−0.38, −0.22)] and the defecation difficulty score [−0.73 (−0.81, −0.65)], since the difference was not statistically significant (p &gt; 0.05). The source of heterogeneity might be related to the state of patient, manipulation of the massages, efficacy of drugs in the control group, and difference in judgment criteria for efficacy. The Egger's test and Begg's test showed that publication bias did not occur in our study.Conclusion: TCM infant massage can increase defecation frequency and reduce the symptoms of constipation in children suffering from functional constipation; in addition, the clinical trial showed beneficial effects. Since some of the RCTs featured a very small sample size, the reliability and validity of our study's conclusion may have been affected as well; therefore, the explanation should be treated with some caution. In the future, a large number of higher-quality RCTs are still needed to confirm the results of our study.


2021 ◽  
Vol 11 (1) ◽  
pp. 55-62
Author(s):  
Alexey G. Pinigin ◽  
Pavel P. Kuzmichev ◽  
Natalya V. Marochko ◽  
Valentina A. Ermolaeva ◽  
Sergey N. Berezutskiy

BACKGROUND: Faecal incontinence as a result of chronic functional constipation is a common problem among children. This condition is socially unacceptable. There is no clear consensus of a universally accepted pathogenesis, diagnostics, and optimal treatment for this condition. New methods of surgical treatment are necessary for accelerated normalization of the retaining faeces process and resolution of faecal incontinence in children. THE AIM: The study was aimed to analyze the efficiency of the new minimally invasive surgery method of the anal sphincter complex restoring with autologous fat injection in children. MATERIALS AND METHODS: The examined group included 31 patients aged from 4 to 17. The patients had chronic constipation combined with faecal incontinence more than once per week. All of them had no lesions of the anal sphincter and pelvic floor muscles. All patients underwent outpatient and inpatient treatment from 2016 to 2019. Patients underwent computed tomographic colonography with virtual colonoscopy in addition to general clinical methods, ultrasound and irrigoscopy. Minimally invasive surgery with autologous fat injection was performed to correct anorectal angle in the following conditions: ineffective nonsurgical treatment for 4-6 months, lengthening of puborectalis muscles, increasing of the anorectal angle more than 100 degrees. RESULTS: We analyzed the complaints of the patients who underwent minimally invasive surgery. The study showed reducing of symptoms severity of chronic constipation up to complete normalization of defecation frequency after surgery (34.5%) in 3 months. The study also showed the complete absence of fecal incontinence in 3 months after this minimally invasive treatment in 83 per cent of children. CONCLUSION: The retrorectal injection of autologous fat leads to fast resolution of faecal incontinence, normalization of defecation frequency and improvement of the life quality as a result.


2021 ◽  
Vol 8 ◽  
Author(s):  
Yuichiro Nishimoto ◽  
Tatsuhiro Nomaguchi ◽  
Yuka Mori ◽  
Masaki Ito ◽  
Yuya Nakamura ◽  
...  

Recent studies have accumulated evidence that the intestinal environment is strongly correlated with host diet, which influences host health. A number of dietary products whose mechanisms of influence operate via the gut microbiota have been revealed, but they are still limited. Here, we investigated the dietary influence of Chlorella, a green alga commercially available as a dietary supplement. A randomised, double-blind, placebo-controlled crossover trial including 40 Japanese participants with constipation was performed. In this study, the primary outcome and secondary outcome were set as defecation frequency and blood folate level, respectively. In both outcomes, no significant differences were detected compared to the control intake. Therefore, we analysed the gut microbiome, gut metabolome, and blood parameters in an integrated manner as an exploratory analysis. We revealed that the consumption of Chlorella increased the level of several dicarboxylic acids in faeces. Furthermore, the analysis showed that individuals with low concentrations of faecal propionate showed an increase in propionate concentration upon Chlorella intake. In addition, increasing blood folate levels were negatively correlated with defecation frequency at baseline. Our study suggested that the effect of Chlorella consumption varies among individuals depending on their intestinal environment, which illustrates the importance of stratified dietary management based on the intestinal environment in individuals.


Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1847
Author(s):  
Sachi Tanaka ◽  
Kana Yamamoto ◽  
Chisato Hamajima ◽  
Fuka Takahashi ◽  
Katsunori Endo ◽  
...  

Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria. Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion. To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study. The pilot intervention study was conducted for healthy volunteers aged 40–64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited. In total, 20 volunteers consumed 30 g of fermented B. rapa L. per day for 4 weeks. The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis. To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks. The fecal bacterial community composition of the volunteers before the intervention was divided into three clades. Regardless of the clade, the defecation frequency significantly increased during the intervention weeks compared with that before the intervention. However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion. The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice. This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration. We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.


Author(s):  
Jirayu Tanprasertsuk ◽  
Lee Ann M Perry ◽  
Devon E Tate ◽  
Ryan W Honaker ◽  
Justin Shmalberg

Abstract Commercial fresh cooked foods have started gaining popularity among American dog owners in recent years. However, nutrient digestibility and the estimation of metabolizable energy (ME) of commercial fresh dog foods remain inadequately understood, even though both measures are critical to provide the intended calories for the target animal. In this preliminary study, different cohorts of normal-weight dogs were fed one of five test diets of comparable macronutrient composition: a chicken-based extruded dry kibble diet (n=12), and chicken- (n=12), beef- (n=6), pork- (n=6), or turkey-based fresh food (n=6) for 10 days. Daily food intake and fecal characteristics were recorded, and fecal samples were collected for nutrient analysis. Despite comparable dry matter (DM) and caloric intakes between the two chicken-based diets, the fresh diet led to lower defecation frequency (1.2±0.2 vs 1.7±0.5 times/d, adjusted p&lt;0.001), lower fecal DM (24±8 vs 47±10 g/d, adjusted p&lt;0.001), and lower fecal calories (92±31 vs 189±43 kcal/d, adjusted p&lt;0.001) than the kibble diet. The apparent total tract digestibility of DM, protein, fat, nitrogen-free extract, and calories of the kibble diet were all significantly lower than any of the fresh diets (adjusted p&lt;0.001 for all). Measured ME per food DM in all of the fresh diets, except that being pork-based, was significantly higher than that of the kibble diet (adjusted p&lt;0.001 for all). For the kibble diet, the modified Atwater calculation underestimated the ME and the NRC 2006 calculation was the most accurate predictor of ME. The standard Atwater calculation performed best for the two fresh diets that had the highest fat content (chicken, beef) and the NRC 2006 calculation performed best for the fresh diet that had the highest protein content (pork). ME of the turkey-based diet was equally overestimated and underestimated with the standard Atwater and NRC 2006 methods, respectively. We propose that commercial and home-prepared fresh diets should be assessed using standard Atwater factors as commonly done in human nutrition, or preferably for commercial products, by direct measurement in conforming feeding trials.


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