Investigation of the protective effects of keratinocyte growth factor (KGF) in a human lipopolysaccharide induced model of acute lung injury

2013 ◽  
Author(s):  
Danny McAuley
Keyword(s):  
Acute Lung Injury ◽  
Growth Factor ◽  
Lung Injury ◽  
Keratinocyte Growth Factor ◽  
Protective Effects

Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair

2002 ◽  
Vol 282 (5) ◽  
pp. L924-L940 ◽  
Author(s):  
Lorraine B. Ware ◽  
Michael A. Matthay
Keyword(s):  
Acute Lung Injury ◽  
Growth Factors ◽  
Growth Factor ◽  
Animal Models ◽  
Lung Injury ◽  
Lung Development ◽  
Therapeutic Potential ◽  
Keratinocyte Growth Factor ◽  
Protective Effects ◽  
Hepatocyte Growth

A growing body of evidence indicates that the epithelial-specific growth factors keratinocyte growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) play important roles in lung development, lung inflammation, and repair. The therapeutic potential of these growth factors in lung disease has yet to be fully explored. KGF has been best studied and has impressive protective effects against a wide variety of injurious stimuli when given as a pretreatment in animal models. Whether this protective effect could translate to a treatment effect in humans with acute lung injury needs to be investigated. FGF-10 and HGF may also have therapeutic potential, but more extensive studies in animal models are needed. Because HGF lacks true epithelial specificity, it may have less potential than KGF and FGF-10 as a targeted therapy to facilitate lung epithelial repair. Regardless of their therapeutic potential, studies of the unique roles played by these growth factors in the pathogenesis and the resolution of acute lung injury and other lung diseases will continue to enhance our understanding of the complex pathophysiology of inflammation and repair in the lung.

Protective Effects of Keratinocyte Growth Factor-2 on Ischemia–Reperfusion–Induced Lung Injury in Rats

2014 ◽  
Vol 50 (6) ◽  
pp. 1156-1165 ◽  
Author(s):  
Xiaocong Fang ◽  
Lingyan Wang ◽  
Lin Shi ◽  
Chengshui Chen ◽  
Qun Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lung Injury ◽  
Ischemia Reperfusion ◽  
Keratinocyte Growth Factor ◽  
Protective Effects

Keratinocyte Growth Factor Gene Transduction Ameliorates Acute Lung Injury And Mortality in Mice

2007 ◽  
Vol 18 (2) ◽  
pp. 130-141 ◽  
Author(s):  
Yasuko Baba ◽  
Takuya Yazawa ◽  
Yumi Kanegae ◽  
Seiko Sakamoto ◽  
Izumu Saito ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Growth Factor ◽  
Lung Injury ◽  
Keratinocyte Growth Factor ◽  
Gene Transduction ◽  
Factor Gene ◽  
Growth Factor Gene

Keratinocyte growth factor-2 is protective in lipopolysaccharide-induced acute lung injury in rats

2014 ◽  
Vol 201 ◽  
pp. 7-14 ◽  
Author(s):  
Lin Tong ◽  
Jing Bi ◽  
Xiaodan Zhu ◽  
Guifang Wang ◽  
Jie Liu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Growth Factor ◽  
Lung Injury ◽  
Keratinocyte Growth Factor

scholarly journals Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

Trials ◽  
2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Laurence JM Cross ◽  
Cecilia M O’Kane ◽  
Cliona McDowell ◽  
Jospeh J Elborn ◽  
Michael A Matthay ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Growth Factor ◽  
Lung Injury ◽  
Study Protocol ◽  
Controlled Trial ◽  
Keratinocyte Growth Factor ◽  
Pulmonary Dysfunction

scholarly journals Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

Trials ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Laurence J. M. Cross ◽  
Cecilia M. O’Kane ◽  
Cliona McDowell ◽  
Jospeh J. Elborn ◽  
Michael A. Matthay ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Growth Factor ◽  
Lung Injury ◽  
Study Protocol ◽  
Controlled Trial ◽  
Keratinocyte Growth Factor ◽  
Pulmonary Dysfunction
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