scholarly journals Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease

2014 ◽  
Vol 6 (11) ◽  
pp. 102
Author(s):  
Long Hoang ◽  
Chisato Shimizu ◽  
Ling Ling ◽  
Ahmad Naim ◽  
Chiea Khor ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kawasaki Disease ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Therapeutic Targets ◽  
Global Gene Expression ◽  
Global Gene Expression Profiling ◽  
Acute Kawasaki Disease ◽  
New Therapeutic Targets

Global gene expression profiling of porcine endometria on Days 12 and 16 of the estrous cycle and pregnancy

2014 ◽  
Vol 82 (6) ◽  
pp. 897-909 ◽  
Author(s):  
Jolanta Kiewisz ◽  
Kamil Krawczynski ◽  
Pawel Lisowski ◽  
Agnieszka Blitek ◽  
Lech Zwierzchowski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Estrous Cycle ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Global Gene Expression Profiling

scholarly journals Global Gene Expression Profiling of Circulating Tumor Cells

2005 ◽  
Vol 65 (12) ◽  
pp. 4993-4997 ◽  
Author(s):  
Denis A. Smirnov ◽  
Daniel R. Zweitzig ◽  
Bradley W. Foulk ◽  
M. Craig Miller ◽  
Gerald V. Doyle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Global Gene Expression Profiling

Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling

2011 ◽  
Vol 300 (1) ◽  
pp. F177-F188 ◽  
Author(s):  
Masanori Kugita ◽  
Kazuhiro Nishii ◽  
Miwa Morita ◽  
Daisuke Yoshihara ◽  
Hiroe Kowa-Sugiyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Kidney Disease ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Early Stage ◽  
Global Gene Expression ◽  
Rt Pcr ◽  
Polycystic Kidney ◽  
Global Gene Expression Profiling

Han:SPRD Cy is a spontaneous rat model of polycystic kidney disease (PKD) caused by a missense mutation in Pkdr1. Cystogenesis in this model is not clearly understood. In the current study, we performed global gene expression profiling in early-stage PKD cyst development in Cy/Cy kidneys and normal (+/+) kidneys at 3 and 7 days of postnatal age. Expression profiles were determined by microarray analysis, followed by validation with real-time RT-PCR. Genes were selected with over 1.5-fold expression changes compared with age-matched +/+ kidneys for canonical pathway analysis. We found nine pathways in common between 3- and 7-day Cy/Cy kidneys. Three significantly changed pathways were designated “Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR) Activation,” “LPS/IL-1-Mediated Inhibition of RXR Function,” and “Liver X Receptor (LXR)/RXR Activation.” These results suggest that RXR-mediated signaling is significantly altered in developing kidneys with mutated Pkdr1. In gene ontology analysis, the functions of these RXR-related genes were found to be involved in regulating cell proliferation and organ morphogenesis. With real-time RT-PCR analysis, the upregulation of Ptx2, Alox15b, OSP, and PCNA, major markers of cell proliferation associated with the RXR pathway, were confirmed in 3- and 7-day Cy/Cy kidneys compared with 3-day +/+ kidneys. The increased RXR protein was observed in both the nucleus and cytoplasm of cystic epithelial cells in early-stage Cy/Cy kidneys, and the RXR-positive cells were strongly positive for PCNA staining. Taken together, cell proliferation and organ morphogenesis signals transduced by RXR-mediated pathways may have important roles for cystogenesis in early-stage PKD in this Pkdr1-mutated Cy rat.

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