scholarly journals Lung ultrasound is a reliable method for evaluating extravascular lung water volume in rodents

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Huan Ma ◽  
Daozheng Huang ◽  
Minzhou Zhang ◽  
Xin Huang ◽  
Shiyu Ma ◽  
...  
2019 ◽  
Vol 9 (18) ◽  
pp. 3923 ◽  
Author(s):  
Xiaoming Zhang ◽  
Boran Zhou ◽  
Alex X. Zhang

Extravascular lung water (EVLW) is a basic symptom of congestive heart failure and other conditions. Computed tomography (CT) is standard method used to assess EVLW, but it requires ionizing radiation and radiology facilities. Lung ultrasound reverberation artifacts called B-lines have been used to assess EVLW. However, analysis of B-line artifacts depends on expert interpretation and is subjective. Lung ultrasound surface wave elastography (LUSWE) was developed to measure lung surface wave speed. This pilot study aimed at measureing lung surface wave speed due to lung water in an ex vivo swine lung model. The surface wave speeds of a fresh ex vivo swine lung were measured at 100 Hz, 200 Hz, 300 Hz, and 400 Hz. An amount of water was then filled into the lung through its trachea. Ultrasound imaging was used to guide the water filling until significant changes were visible on the imaging. The lung surface wave speeds were measured again. It was found that the lung surface wave speed increases with frequency and decreases with water volume. These findings are confirmed by experimental results on an additional ex vivo swine lung sample.


2019 ◽  
Vol 38 (7) ◽  
pp. 757-766 ◽  
Author(s):  
Kamal S. Ayyat ◽  
Toshihiro Okamoto ◽  
Hiromichi Niikawa ◽  
Yoshifumi Itoda ◽  
Siddharth Dugar ◽  
...  

2019 ◽  
Vol 35 (11) ◽  
pp. 1356-1362 ◽  
Author(s):  
Sunil Nair ◽  
Harald Sauthoff

Aggressive fluid resuscitation has become standard of care for hypotensive patients with sepsis. However, sepsis is a syndrome that occurs in patients with diverse underlying physiology and a one-size-fits-all approach to fluid administration seems misguided. To individualize fluid management, several methods to assess fluid responsiveness have been validated, but even in fluid responsive patients, fluid administration may still be harmful and lead to pulmonary edema. Hence, to individualize fluid management, in addition to fluid responsiveness, fluid tolerance needs to be assessed. This article examines whether lung ultrasound can be useful to detect excess extravascular lung water (EVLW) and thus assess fluid tolerance. The physiology of EVLW and the principles of lung ultrasound are briefly described. Articles examining the correlation between EVLW and lung ultrasound findings in various clinical settings are carefully reviewed. Overall, lung ultrasound has been found to be an excellent tool to detect EVLW, but large outcome studies investigating lung ultrasound-guided fluid management are still lacking.


1992 ◽  
Vol 72 (2) ◽  
pp. 686-693 ◽  
Author(s):  
C. A. Dawson ◽  
D. L. Roerig ◽  
D. A. Rickaby ◽  
L. D. Nelin ◽  
J. H. Linehan ◽  
...  

Estimates of extravascular lung water volume (Qew) by use of the multiple indicator-dilution method with a hydrophilic indicator such as tritiated water, along with a vascular reference indicator, depend not only on tissue hydration but also on tissue perfusion. Separation of these effects might be facilitated if both hydrophilic and lipophilic indicators were used, with the assumption that the extravascular volume accessible to the lipophilic indicator would be independent of hydration. We found that in isolated perfused dog lung lobes the extravascular volume accessible to the lipophilic amine [14C]diazepam (Qed) was inversely proportional to the albumin concentration of the perfusate. This suggested that while the bolus was in the lungs, only a small fraction of the diazepam was in the aqueous phase of either lung tissue or perfusate. Changing the flow rate over a fairly wide range had little influence on the pattern of the tritiated water or [14C]diazepam effluent concentration curves when time was normalized to the lobar mean transit time. This suggests that the association of the diazepam with both the plasma albumin and the lipoid fraction of the tissue was in very rapid equilibrium on the time scale of a single pass through the lung lobe and that there was little barrier to its diffusion to and from the tissue. When the extravascular water volume was increased by either raising the hydrostatic pressure or instilling saline into the airways, both Qew and Qew/Qed increased.(ABSTRACT TRUNCATED AT 250 WORDS)


Critical Care ◽  
2009 ◽  
Vol 13 (4) ◽  
pp. R107 ◽  
Author(s):  
Benjamin Maddison ◽  
Christopher Wolff ◽  
George Findlay ◽  
Peter Radermacher ◽  
Charles Hinds ◽  
...  

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