scholarly journals TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Narinder Grover ◽  
Prateek Bhatia ◽  
Antriksh Kumar ◽  
Minu Singh ◽  
Deepesh Lad ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Asian Population ◽  
Liver Function Tests ◽  
North India ◽  
P Value ◽  
Nudix Hydrolase ◽  
South Asian Population ◽  
Inflammatory Bowel ◽  
A Prospective Study

Abstract Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively. Exact role of these polymorphisms in South Asian population with inflammatory bowel disease (IBD) is uncertain. Methods We included consecutive patients with IBD who were initiated on thiopurines at a center in North India. The dosage of thiopurines was titrated using regular monitoring of hemogram and liver function tests. Three TPMT polymorphisms (c.238 G > C, c.460 G > A, and c.719A > G) and one NUDT15 polymorphism (c.415 C > T) were assessed. Comparison regarding incidence of leukopenia and maximum tolerated thiopurine dosage was performed between those with wild polymorphism and those with TPMT and NUDT15 polymorphisms, respectively. Results Of the 119 patients (61 males, mean age 36.8 ± 13.5 years), 105 (88.2%) had ulcerative colitis and 14 (11.8%) had Crohn’s disease. Leukopenia was noted in 33 (27.7%), gastrointestinal intolerance in 5 (4.2%) and pancreatitis in 2 (1.6%). TPMT polymorphisms were detected amongst five patients of whom 1 developed leukopenia. NUDT15 polymorphism was noted in 13 patients of whom 7 had leukopenia. The odds of developing leukopenia in TPMT polymorphism were non-significant (0.77, 95% CI:0.0822 to 7.2134, P = 0.819) but were significantly higher in those with NUDT15 polymorphism (3.5933, 1.1041 to 11.6951, P value: = 0.0336). Conclusion NUDT15 polymorphism was more frequent than TPMT polymorphisms and was associated with thiopurine induced leukopenia. However, the tested polymorphisms account for only 24.2% of the risk of thiopurine induced leukopenia.

scholarly journals Genetic associations of inflammatory bowel disease in a South Asian population

2018 ◽  
Vol 6 (15) ◽  
pp. 908-915 ◽  
Author(s):  
Madunil Anuk Niriella ◽  
Isurujith Kongala Liyanage ◽  
Senerath Kuleesha Kodisinghe ◽  
Arjuna Priyadarsin De Silva ◽  
Nimna Rajapakshe ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
Asian Population ◽  
Genetic Associations ◽  
South Asian Population ◽  
Inflammatory Bowel

scholarly journals The Need for Culturally Competent Care Within Gastroenterology Services: Evidence from Research with Adults of South Asian Origin Living with Inflammatory Bowel Disease

2020 ◽  
Author(s):  
Suzanne Mukherjee ◽  
Bryony Beresford ◽  
Karl Atkin ◽  
Shaji Sebastian
Keyword(s):  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
Extended Family ◽  
Religious Faith ◽  
Asian Population ◽  
Structured Interviews ◽  
South Asian Population ◽  
Asian Populations ◽  
Inflammatory Bowel

Abstract Background and Aims It is widely acknowledged that the incidence of inflammatory bowel disease [IBD] is rising within South Asian populations, yet research into the experiences of this group of patients is rare. In this study the lived experiences of UK South Asian adults with IBD, including support from gastroenterology services, was investigated. Methods A sample of 33 patients representing the diversity of the UK South Asian population were recruited through five gastroenterology clinics in England. In-depth semi-structured interviews were conducted, audio-recorded, transcribed and analysed using the Framework approach. Results Although many experiences align with those of the general IBD population, participants believed that South Asian cultures and/or religions can lead to additional challenges. These are linked to: family and friends’ understanding of IBD; self and family attributions regarding IBD; stigma surrounding ill health; the taboo of bowel symptoms; managing ‘spicy food’; beliefs about food and ill health; roles within the family; living with extended family; the use of complementary and alternative therapies; and visits to family overseas. Religious faith helped many to cope with having IBD, but symptoms could hamper their ability to practise faith. Gastroenterology services were viewed positively, but unmet needs were identified, some of which were culturally specific. Conclusion Gastroenterology services have an important role to play in helping patients to overcome the challenges they encounter in their everyday life, both by providing individual patients with culturally appropriate care and advice, and via interventions to increase awareness and understanding of IBD within wider South Asian communities.

Mo1356 Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype

2013 ◽  
Vol 144 (5) ◽  
pp. S-645-S-646
Author(s):  
Matthew W. Carroll ◽  
Hira S. Gill ◽  
Jonathan Simkin ◽  
Lee-Ann M. Carroll ◽  
Vered Pinsk ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
British Columbia ◽  
South Asian ◽  
Bowel Disease ◽  
Asian Population ◽  
Severe Phenotype ◽  
South Asian Population ◽  
Inflammatory Bowel

Inflammatory Bowel Disease in the South Asian Population of Northwest England

2008 ◽  
Vol 103 (1) ◽  
pp. 242-243 ◽  
Author(s):  
Sheikh T Rashid ◽  
Shameena Bharucha ◽  
Syed I Jamallulail ◽  
Gurvinder S Banait ◽  
Karen Kemp ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
Asian Population ◽  
The South ◽  
South Asian Population ◽  
Inflammatory Bowel

scholarly journals Longitudinal Trajectory of Fatigue in Patients With Inflammatory Bowel Disease: A Prospective Study

2020 ◽  
Author(s):  
Nienke Z Borren ◽  
Millie D Long ◽  
Robert S Sandler ◽  
Ashwin N Ananthakrishnan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Chronic Illness ◽  
Prospective Study ◽  
Functional Assessment ◽  
Bowel Disease ◽  
Symptom Resolution ◽  
Chronic Illness Therapy ◽  
Inflammatory Bowel ◽  
A Prospective Study

Abstract Background Fatigue is a disabling symptom in patients with inflammatory bowel disease (IBD). Its prevalence, mechanism, and impact remain poorly understood. We determined changes in fatigue status over time and identified predictors of incident or resolving fatigue. Methods This was a prospective study nested within the IBD Partners cohort. Participants prospectively completed the Multidimensional Fatigue Inventory and the Functional Assessment of Chronic Illness Therapy-Fatigue at baseline, 6 months, and 12 months. A Functional Assessment of Chronic Illness Therapy-Fatigue score ≤43 defined significant fatigue. Multivariable regression models using baseline covariates were used to identify risk factors for incident fatigue at 6 months and to predict the resolution of fatigue. Results A total of 2429 patients (1605 with Crohn disease, 824 with ulcerative colitis) completed a baseline assessment, and 1057 completed a second assessment at 6 months. Persistent fatigue (at baseline and at 6 months) was the most common pattern, affecting two-thirds (65.8%) of patients. One-sixth (15.7%) of patients had fatigue at 1 timepoint, whereas fewer than one-fifth (18.5%) of patients never reported fatigue. Among patients not fatigued at baseline, 26% developed fatigue at 6 months. The strongest predictor of incident fatigue was sleep disturbance at baseline (odds ratio, 2.91; 95% confidence interval, 1.48–5.72). In contrast, only 12.3% of those with fatigue at baseline had symptom resolution by month 6. Resolution was more likely in patients with a diagnosis of ulcerative colitis, quiescent disease, and an absence of significant psychological comorbidity. Conclusions Fatigue is common in patients with IBD. However, only a few fatigued patients experience symptom resolution at 6 or 12 months, suggesting the need for novel interventions to ameliorate its impact.

Sign in / Sign up

Export Citation Format

Share Document