The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

Abstract Background To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19). Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed. Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group. Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

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The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

10.21203/rs.3.rs-35018/v3 ◽

2020 ◽

Author(s):

Zhe Zhu ◽

Ting Cai ◽

Lingyan Fan ◽

Kehong Lou ◽

Xin Hua ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Clinical Condition ◽

Recovery Phase ◽

Control Group ◽

Converting Enzyme ◽

Baseline Serum ◽

Serum Angiotensin Converting Enzyme ◽

Severe Group ◽

Ace Activity

Abstract Background To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19).Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed.Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group.Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

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The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

10.21203/rs.3.rs-35018/v2 ◽

2020 ◽

Author(s):

Zhe Zhu ◽

Ting Cai ◽

Lingyan Fan ◽

Kehong Lou ◽

Xin Hua ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Clinical Condition ◽

Recovery Phase ◽

Control Group ◽

Converting Enzyme ◽

Baseline Serum ◽

Serum Angiotensin Converting Enzyme ◽

Severe Group ◽

Ace Activity

Abstract Objective To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19).Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed.Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group.Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

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The potential role of serum angiotensin-converting enzyme in the coronavirus disease 2019

10.21203/rs.3.rs-35018/v1 ◽

2020 ◽

Author(s):

Zhe Zhu ◽

Ting Cai ◽

Lingyan Fan ◽

Kehong Lou ◽

Xin Hua ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Clinical Condition ◽

Recovery Phase ◽

Converting Enzyme ◽

Baseline Serum ◽

Serum Angiotensin Converting Enzyme ◽

Severe Group ◽

Ace Activity ◽

Normal Controls

Abstract Objective To explore the clinical significance of serum angiotensin-converting enzyme (ACE) in the coronavirus disease 2019 (COVID-19).Methods In this retrospective study, a cohort of 136 consecutive patients with confirmed COVID-19 was recruited. Demographics and clinical data were recorded. The serum ACE activity were measured at baseline and recovery phase, and its relationship with clinical condition was analyzed.Results Of the 136 patients with confirmed COVID-19, 16 severe cases were older, had higher body mass index (BMI) and proportion of hypertension when compared with 120 non-severe cases. In comparison to normal controls, the baseline serum ACE activity in the severe group and non-severe group were both decreased, with the lowest level in the severe group. However, the serum ACE activity raised in the recovery phase, and there were no significant differences among severe group, non-severe group and normal controls.Conclusion Serum ACE could be used as a marker to reflect the clinical condition of COVID-19, since its low level was associated with the severity of COVID-19 at baseline, and it increased with the remission of the disease.

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Serum angiotensin converting enzyme (S-ACE) activity in patients with chronic renal failure on regular hemodialysis.

Japanese Heart Journal ◽

10.1536/ihj.25.87 ◽

1984 ◽

Vol 25 (1) ◽

pp. 87-92 ◽

Cited By ~ 3

Author(s):

Hiroshi MIURA ◽

Mahito NAKAYAMA ◽

Tatsuo SATO

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Serum Angiotensin Converting Enzyme ◽

Ace Activity ◽

Regular Hemodialysis

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Gender difference of serum angiotensin-converting enzyme (ACE) activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320313475906 ◽

2013 ◽

Vol 15 (4) ◽

pp. 547-552 ◽

Cited By ~ 10

Author(s):

Ya-Feng Zhang ◽

Qiong Cheng ◽

Nelson LS Tang ◽

Tanya TW Chu ◽

Brian Tomlinson ◽

...

Keyword(s):

Gender Difference ◽

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Deletion Polymorphism ◽

Serum Angiotensin Converting Enzyme ◽

Elderly Chinese ◽

Ace Activity

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Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference interval for adults

Clinical Chemistry ◽

10.1093/clinchem/36.2.344 ◽

1990 ◽

Vol 36 (2) ◽

pp. 344-346 ◽

Cited By ~ 57

Author(s):

B Bénéteau-Burnat ◽

B Baudin ◽

G Morgant ◽

F C Baumann ◽

J Giboudeau

Keyword(s):

Angiotensin Converting Enzyme ◽

Hormonal Regulation ◽

Reference Interval ◽

Healthy Children ◽

Age Group ◽

Converting Enzyme ◽

Serum Angiotensin Converting Enzyme ◽

Age Related ◽

Ace Activity ◽

Physiological Variations

Abstract Angiotensin-converting enzyme (ACE) was measured in serum of 187 healthy children between the ages six months and 18 years. Results were pooled for five-year age intervals and compared with the reference values for adults that we previously determined [Clin Chem 1986;32:884-6). Results for each age group were also studied as a function of sex. Children had higher ACE activities in serum than did adults (P less than 0.001), but these activities were age-related only from age four to 18 years. Adolescents showed sex-related differences, with higher serum ACE activities in boys than in girls (P less than 0.05). Both sex- and age-related differences may be related to a steroid hormonal regulation of ACE biosynthesis. We also verified that children with sarcoidosis (n = 20) had significantly increased serum ACE activity. Such physiological variations in serum ACE activity must be taken into account for diagnosing sarcoidosis in children, for following the course of the disease, and for evaluating the accuracy of therapy.

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The role of angiotensin-converting enzyme in the rat epididymis

Journal of Endocrinology ◽

10.1677/joe.0.1250457 ◽

1990 ◽

Vol 125 (3) ◽

pp. 457-465 ◽

Cited By ~ 37

Author(s):

P. Y. D. Wong ◽

C. N. Uchendu

Keyword(s):

Angiotensin Converting Enzyme ◽

Blood Serum ◽

Male Rats ◽

Converting Enzyme ◽

Efferent Duct ◽

Duct Ligation ◽

Rat Epididymis ◽

Epididymal Spermatozoa ◽

Ace Activity

ABSTRACT In order to investigate the role of renin angiotensin in the epididymis, angiotensin-converting enzyme (ACE) activity and angiotensin I (AI) and angiotensin II (AII) concentrations were measured in the male reproductive tract and blood serum of the rat. High ACE activity was detected in the rat epididymis, with a major part of the activity being associated with epididymal spermatozoa. When spermatozoa were prevented from entering the epididymis by efferent duct ligation, the ACE activity in the epididymis was greatly reduced. The epithelial cells lining the epididymal duct were also shown to possess ACE activity which was dependent upon circulating androgens. Treatment of male rats with captopril at a single oral dose (20 mg/kg) significantly inhibited the ACE activity in the blood serum but had no effect on the activity of the epididymal fluid. The intraluminal ACE was protected from the circulating captopril by the blood–epididymis barrier. Long-term treatment with captopril (20 mg/kg per day, 8 weeks), however, caused an increase in blood serum ACE activity but was without effect on intraluminal ACE. The fertility and fecundity of male rats after treatment were apparently normal. The concentrations of AI and AII were high in the epididymal plasma and epididymal cell when compared with the respective concentrations in blood serum. The intraluminal AII concentration found (13 nmol/l) was close to the threshold concentrations that stimulate anion (and fluid) secretion in cultured epididymal epithelium in vitro. The high intraluminal AII concentration could not have been derived from the testicular fluid or spermatozoa since the rete testis fluid and sperm contained little AII. When spermatozoa were prevented from entering the epididymis by efferent duct ligation, the AII concentration of the epididymal plasma was almost completely abolished, indicating that intraluminal AII was formed endogenously in the epididymal lumen by sperm ACE. We propose that ACE released by epididymal spermatozoa converts AI (formed from the epididymal epithelial cells) to AII which plays a paracrine role in regulating electrolyte and fluid transport through apical membrane angiotensin receptors. Journal of Endocrinology (1990) 125, 457–465

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A pilot investigation into the effects of acute normobaric hypoxia, high altitude exposure and exercise on serum angiotensin-converting enzyme, aldosterone and cortisol

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320318782782 ◽

2018 ◽

Vol 19 (2) ◽

pp. 147032031878278 ◽

Cited By ~ 3

Author(s):

Mark Cooke ◽

Richard Cruttenden ◽

Adrian Mellor ◽

Andrew Lumb ◽

Stewart Pattman ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

High Altitude ◽

Prolonged Exposure ◽

Normobaric Hypoxia ◽

Converting Enzyme ◽

Serum Angiotensin Converting Enzyme ◽

Post Exercise ◽

Altitude Exposure ◽

Pilot Investigation ◽

Ace Activity

Introduction: Aldosterone decreases at high altitude (HA) but the effect of hypoxia on angiotensin-converting enzyme (ACE), a key step in the renin-angiotensin-aldosterone system, is unclear. Methods: We investigated the effects of exercise and acute normobaric hypoxia (NH, ~11.0% FiO2) on nine participants and six controls undertaking the same exercise at sea level (SL). NH exposure lasted 5 hours with 90 minutes of submaximal treadmill walking. Blood samples for aldosterone, ACE and cortisol were taken throughout exposure and at rest during a trek to HA (5140 m) in eight separate participants. Results: There was no difference in cortisol or aldosterone between groups pre-exercise. Aldosterone rose with exercise to a greater extent at SL than in NH (post-exercise: 700 ± 325 versus 335 ± 238 pmol/L, mean ± SD, p = 0.044). Conversely, cortisol rose to a greater extent in NH (post-exercise: 734 ± 165 versus 344 ± 159 nmol/L, mean ± SD, p = 0.001). There were no differences in ACE activity. During the trek to HA, resting aldosterone and cortisol reduced with no change in ACE. Conclusions: Acute NH subdues the exercise-associated rise in aldosteroe but stimulates cortisol, whereas prolonged exposure at HA reduces both resting aldosterone and cortisol. As ACE activity was unchanged in both environments, this is not the mechanism underlying the fall in aldosterone.

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