scholarly journals Gender difference of serum angiotensin-converting enzyme (ACE) activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese

2013 ◽  
Vol 15 (4) ◽  
pp. 547-552 ◽  
Author(s):  
Ya-Feng Zhang ◽  
Qiong Cheng ◽  
Nelson LS Tang ◽  
Tanya TW Chu ◽  
Brian Tomlinson ◽  
...  
Keyword(s):  
Gender Difference ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Serum Angiotensin Converting Enzyme ◽  
Elderly Chinese ◽  
Ace Activity

Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference interval for adults

1990 ◽  
Vol 36 (2) ◽  
pp. 344-346 ◽  
Author(s):  
B Bénéteau-Burnat ◽  
B Baudin ◽  
G Morgant ◽  
F C Baumann ◽  
J Giboudeau
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Hormonal Regulation ◽  
Reference Interval ◽  
Healthy Children ◽  
Age Group ◽  
Converting Enzyme ◽  
Serum Angiotensin Converting Enzyme ◽  
Age Related ◽  
Ace Activity ◽  
Physiological Variations

Abstract Angiotensin-converting enzyme (ACE) was measured in serum of 187 healthy children between the ages six months and 18 years. Results were pooled for five-year age intervals and compared with the reference values for adults that we previously determined [Clin Chem 1986;32:884-6). Results for each age group were also studied as a function of sex. Children had higher ACE activities in serum than did adults (P less than 0.001), but these activities were age-related only from age four to 18 years. Adolescents showed sex-related differences, with higher serum ACE activities in boys than in girls (P less than 0.05). Both sex- and age-related differences may be related to a steroid hormonal regulation of ACE biosynthesis. We also verified that children with sarcoidosis (n = 20) had significantly increased serum ACE activity. Such physiological variations in serum ACE activity must be taken into account for diagnosing sarcoidosis in children, for following the course of the disease, and for evaluating the accuracy of therapy.

scholarly journals The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhe Zhu ◽  
Ting Cai ◽  
Lingyan Fan ◽  
Kehong Lou ◽  
Xin Hua ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Condition ◽  
Recovery Phase ◽  
Control Group ◽  
Converting Enzyme ◽  
Baseline Serum ◽  
Serum Angiotensin Converting Enzyme ◽  
Severe Group ◽  
Ace Activity

Abstract Background To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19). Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed. Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group. Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

scholarly journals The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

2020 ◽  
Author(s):  
Zhe Zhu ◽  
Ting Cai ◽  
Lingyan Fan ◽  
Kehong Lou ◽  
Xin Hua ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Condition ◽  
Recovery Phase ◽  
Control Group ◽  
Converting Enzyme ◽  
Baseline Serum ◽  
Serum Angiotensin Converting Enzyme ◽  
Severe Group ◽  
Ace Activity

Abstract Background To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19).Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed.Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group.Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

scholarly journals The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

2020 ◽  
Author(s):  
Zhe Zhu ◽  
Ting Cai ◽  
Lingyan Fan ◽  
Kehong Lou ◽  
Xin Hua ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Condition ◽  
Recovery Phase ◽  
Control Group ◽  
Converting Enzyme ◽  
Baseline Serum ◽  
Serum Angiotensin Converting Enzyme ◽  
Severe Group ◽  
Ace Activity

Abstract Objective To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19).Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed.Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group.Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

scholarly journals A pilot investigation into the effects of acute normobaric hypoxia, high altitude exposure and exercise on serum angiotensin-converting enzyme, aldosterone and cortisol

2018 ◽  
Vol 19 (2) ◽  
pp. 147032031878278 ◽  
Author(s):  
Mark Cooke ◽  
Richard Cruttenden ◽  
Adrian Mellor ◽  
Andrew Lumb ◽  
Stewart Pattman ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Altitude ◽  
Prolonged Exposure ◽  
Normobaric Hypoxia ◽  
Converting Enzyme ◽  
Serum Angiotensin Converting Enzyme ◽  
Post Exercise ◽  
Altitude Exposure ◽  
Pilot Investigation ◽  
Ace Activity

Introduction: Aldosterone decreases at high altitude (HA) but the effect of hypoxia on angiotensin-converting enzyme (ACE), a key step in the renin-angiotensin-aldosterone system, is unclear. Methods: We investigated the effects of exercise and acute normobaric hypoxia (NH, ~11.0% FiO2) on nine participants and six controls undertaking the same exercise at sea level (SL). NH exposure lasted 5 hours with 90 minutes of submaximal treadmill walking. Blood samples for aldosterone, ACE and cortisol were taken throughout exposure and at rest during a trek to HA (5140 m) in eight separate participants. Results: There was no difference in cortisol or aldosterone between groups pre-exercise. Aldosterone rose with exercise to a greater extent at SL than in NH (post-exercise: 700 ± 325 versus 335 ± 238 pmol/L, mean ± SD, p = 0.044). Conversely, cortisol rose to a greater extent in NH (post-exercise: 734 ± 165 versus 344 ± 159 nmol/L, mean ± SD, p = 0.001). There were no differences in ACE activity. During the trek to HA, resting aldosterone and cortisol reduced with no change in ACE. Conclusions: Acute NH subdues the exercise-associated rise in aldosteroe but stimulates cortisol, whereas prolonged exposure at HA reduces both resting aldosterone and cortisol. As ACE activity was unchanged in both environments, this is not the mechanism underlying the fall in aldosterone.

Extreme elevation of serum angiotensin-converting enzyme (ACE) activity: always consider familial ACE hyperactivity

2014 ◽  
Vol 51 (2) ◽  
pp. 289-293 ◽  
Author(s):  
Karlijn Stouten ◽  
Marjan van de Werken ◽  
Ilja Tchetverikov ◽  
Mohammed Saboerali ◽  
Henricus Jan Vermeer ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Serum Angiotensin Converting Enzyme ◽  
Ace Activity

scholarly journals Serum angiotensin converting enzyme(ACE) activity in various chronic liver diseases and its clinical significance.

Kanzo ◽  
1987 ◽  
Vol 28 (9) ◽  
pp. 1267-1268
Author(s):  
Masato MIYAGAWA ◽  
Shiro MAEYAMA ◽  
Hideki YOSHIDA ◽  
Makoto KOHNO ◽  
Kazuhiko OKABE ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Converting Enzyme ◽  
Chronic Liver Diseases ◽  
Serum Angiotensin Converting Enzyme ◽  
Ace Activity

scholarly journals Association of insertion deletion polymorphism of the ACE gene with factors of circulating rennin-angiotensin-aldosterone system and endothelial function of skin microvassals in preeclampsia

2011 ◽  
Vol 10 (4) ◽  
pp. 32-36
Author(s):  
O. V. Radkov ◽  
M. N. Kalinkin ◽  
V. V. Zavarin
Keyword(s):  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Endothelial Function ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Activity Level ◽  
Renin Activity ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Ace Activity

The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.

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