scholarly journals Sleep apnea prevalence in chronic kidney disease - association with total body water and symptoms

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Hsin-Chia Huang ◽  
Giles Walters ◽  
Girish Talaulikar ◽  
Derek Figurski ◽  
Annette Carroll ◽  
...  
2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i559-i560
Author(s):  
Anastasia Markaki ◽  
Periklis kyriazis ◽  
Athanasios Rizos ◽  
Vasilis Zafiropulos ◽  
Stamatia Skoulikidi ◽  
...  

2014 ◽  
Vol 36 (4) ◽  
Author(s):  
José Resende de Castro Júnior ◽  
Natália Fernandes ◽  
Thiago Bento de Paiva Lacet ◽  
Fábio Simplício Maia ◽  
Glauco Resende Bonato ◽  
...  

2019 ◽  
pp. 04-13
Author(s):  
Colin Jones ◽  
Louise Wells ◽  
Graham Woodrow ◽  
David Ashford

Background: Metabolic acidosis in chronic kidney disease (CKD) is often treated with oral sodium bicarbonate. There is limited evidence around the effects of sodium bicarbonate on extracellular fluid and blood pressure in CKD. Methods: In a double blind randomised comparison patients with stage 3-5 CKD were randomised to either oral sodium bicarbonate 1.5 g three times a day (n=18) or placebo (n=21) for 4 weeks. Assessments performed at 0 and 4 weeks included: body weight, office blood pressure and assessment for peripheral/pulmonary oedema; serum creatinine, electrolytes and venous bicarbonate; 24-hour urine for sodium excretion; extracellular fluid volume and total body water determined by sodium bromide and deuterium oxide dilution respectively; extracellular fluid volume and total body water by bioimpedance. Differences between the active and placebo groups at week 4 were analysed by ANCOVA. Results: At week 4, serum bicarbonate was higher (25.6±2.4 vs 23.3±3.1 mmol/l) and blood urea lower (14.2±5.6 vs 17.0±5.8 mmol/l) in the active treatment group. Urine sodium concentration was also higher (82.7±25.3 vs 59.0±21.9 mmol/l). Extracellular fluid volume (20.0±4.3 vs 18.0±2.9) and total body water (42.3±9.6 vs 39.0±6.8) measured by bioimpedance and total body water by deuterium dilution (41.7±8.3 vs 39.4±6.2) were significantly greater in the treatment arm at week 4. Differences in systolic and diastolic blood pressure did not reach statistical significance. Conclusions: Oral sodium bicarbonate has a biological effect and increases body water content, without evidence of a clinical consequence. This may reflect the fact that some of the ingested sodium is excreted in the urine.


Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 650
Author(s):  
Kaori Kohatsu ◽  
Sayaka Shimizu ◽  
Yugo Shibagaki ◽  
Tsutomu Sakurada

Whether dietary salt intake affects chronic kidney disease (CKD) progression remains unclear. We conducted a retrospective cohort study to analyze the effects of both daily salt intake (DSI) and volume status on renal outcomes in 197 CKD patients. DSI was estimated by 24-h urinary sodium excretion and volume status was assessed by the ratio of extracellular water (ECW) to total body water (TBW) measured by bioelectrical impedance analysis (BIA). We divided patients into two groups according to DSI (6 g/day) or median ECW/TBW (0.475) and compared renal outcomes of each group. Furthermore, we classified and analyzed four groups according to both DSI and ECW/TBW. The higher DSI group showed a 1.69-fold (95% confidence interval (CI) 1.12–2.57, p = 0.01) excess risk of outcome occurrence compared to the lower group. Among the four groups, compared with Group 1 (low DSI and low ECW/TBW), Group 3 (high DSI and low ECW/TBW) showed a 1.84-fold (95% CI 1.03–3.30, p = 0.04) excess risk of outcome occurrence; however, Group 2 (low DSI and high ECW/TBW) showed no significant difference. High salt intake appears to be associated with poor renal outcome independent of blood pressure (BP), proteinuria, and volume status.


Author(s):  
Brett S. Nickerson ◽  
Samantha V. Narvaez ◽  
Mitzy I. Juarez ◽  
Stefan A. Czerwinski

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