scholarly journals A pilot study: lenticule quality of hyperopic small incision lenticule extraction (SMILE) in rabbits

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu Zhao ◽  
Feng Zhao ◽  
Tian Han ◽  
Jing Zhao ◽  
Xingtao Zhou
2020 ◽  
Author(s):  
Yu Zhao ◽  
Feng Zhao ◽  
Tian Han ◽  
Jing Zhao ◽  
Xingtao Zhou

Abstract Background: To evaluate lenticule surface characteristics of small incision lenticule extraction (SMILE) for hyperopia correction in rabbits. Methods: The left and right eyes of 8 rabbits were divided into two groups. The right eyes were assigned to a hyperopia group, and the left eyes to a myopia group. The rabbits received SMILE procedures with +3.00 D and –3.00 D correction for the hyperopia and myopia groups, respectively. Extracted lenticules were examined via scanning electron microscopy. Lenticules from odd-numbered rabbits were accessed with the anterior surface, and lenticules from even-numbered rabbits were observed with the posterior surface. A previously established scoring system was used to evaluate lenticule surface characteristics. Statistical analysis was conducted to compare the scores between the two groups. Results: All procedures were performed successfully, and the lenticules were extracted smoothly. One myopia lenticule that was facing downward was handled failed in preparation for imaging, thus 15 lenticules were ultimately graded. Twelve lenticules exhibited smooth surfaces, and regularly arranged tissue bridges were observed in almost all regions. Three lenticules exhibited a partially rough surface and irregularities affecting more than 10% of the lenticules (2 in the hyperopia group and 1 in the myopia group). Rough lenticules occurred in twice as many Lenticules in the hyperopia group compared to the myopia group. Conclusions: Scan quality of lenticules after SMILE for hyperopia correction is comparable to that of myopia lenticules. The shape of hyperopic lenticule may increase the difficulty of surgical manipulation and result in surface roughness.


2019 ◽  
Author(s):  
Yu Zhao ◽  
Feng Zhao ◽  
Tian Han ◽  
Jing Zhao ◽  
Xingtao Zhou

Abstract Purpose: To evaluate lenticule surface characteristics of small incision lenticule extraction (SMILE) for hyperopia correction in rabbits. Methods: The left and right eyes of 8 rabbits were divided into two groups. The right eyes were assigned to a hyperopia group, and the left eyes to a myopia group. The rabbits received SMILE procedures with +3.00 D and –3.00 D correction for the hyperopia and myopia groups, respectively. Extracted lenticules were examined via scanning electron microscopy. Lenticules from odd-numbered rabbits were accessed with the anterior surface, and lenticules from even-numbered rabbits were observed with the posterior surface. A previously established scoring system was used to evaluate lenticule surface characteristics. Statistical analysis was conducted to compare the scores between the two groups. Results: All procedures were performed successfully, and the lenticules were extracted smoothly. One myopia lenticule that was facing downward was handled failed in preparation for imaging, thus 15 lenticules were ultimately graded. Twelve lenticules exhibited smooth surfaces, and regularly arranged tissue bridges were observed in almost all regions. Three lenticules exhibited a partially rough surface and irregularities affecting more than 10% of the lenticules (2 in the hyperopia group and 1 in the myopia group). Rough lenticules occurred in twice as many Lenticules in the hyperopia group compared to the myopia group. Conclusions: Scan quality of lenticules after SMILE for hyperopia correction is comparable to that of myopia lenticules. The shape of hyperopic lenticule may increase the difficulty of surgical manipulation and result in surface roughness.


2020 ◽  
Author(s):  
Yu Zhao ◽  
Feng Zhao ◽  
Tian Han ◽  
Jing Zhao ◽  
Xingtao Zhou

Abstract Background: To evaluate lenticule surface characteristics of small incision lenticule extraction (SMILE) for hyperopia correction in rabbits.Methods: The left and right eyes of 8 rabbits were divided into two groups. The right eyes were assigned to a hyperopia group, and the left eyes to a myopia group. The rabbits received SMILE procedures with +3.00 D and –3.00 D correction for the hyperopia and myopia groups, respectively. Extracted lenticules were examined via scanning electron microscopy. Lenticules from odd-numbered rabbits were accessed with the anterior surface, and lenticules from even-numbered rabbits were observed with the posterior surface. A previously established scoring system was used to evaluate lenticule surface characteristics. Statistical analysis was conducted to compare the scores between the two groups.Results: All procedures were performed successfully, and the lenticules were extracted smoothly. One myopia lenticule that was facing downward was handled failed in preparation for imaging, thus 15 lenticules were ultimately graded. Twelve lenticules exhibited smooth surfaces, and regularly arranged tissue bridges were observed in almost all regions. Three lenticules exhibited a partially rough surface and irregularities affecting more than 10% of the lenticules (2 in the hyperopia group and 1 in the myopia group). Rough lenticules occurred in twice as many Lenticules in the hyperopia group compared to the myopia group.Conclusions: Scan quality of lenticules after SMILE for hyperopia correction is comparable to that of myopia lenticules. The shape of hyperopic lenticule may increase the difficulty of surgical manipulation and result in surface roughness.


2020 ◽  
Vol 98 (7) ◽  
Author(s):  
Jakob Siedlecki ◽  
Valerie Schmelter ◽  
Benedikt Schworm ◽  
Wolfgang J. Mayer ◽  
Siegfried G. Priglinger ◽  
...  

2019 ◽  
Vol 45 (11) ◽  
pp. 1575-1583 ◽  
Author(s):  
Valerie Schmelter ◽  
Martin Dirisamer ◽  
Jakob Siedlecki ◽  
Mehdi Shajari ◽  
Thomas C. Kreutzer ◽  
...  

2020 ◽  
Author(s):  
Min Lang ◽  
Kaiwei Cao ◽  
Ting Liu ◽  
Jiao Pan ◽  
Jian Ye

Abstract Background To investigate long-term refractive visual quality outcomes and vision-related quality of life after small-incision lenticule extraction (SMILE) in the treatment of high myopia.Methods Thirty patients (60 eyes) with high myopia who underwent SMILE more than 5 years previously were selected as the SMILE group. Another 30 high myopia patients (60 eyes) who had worn corrective spectacles for more than 5 years were selected as the control group. In the SMILE group, the postoperative follow-up times were 3 months, 6 months, 1 year and 5 years. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), and ocular axial length (AL) were analysed. The Chinese version of the National Eye Institute Visual Function Questionnaire-25 (CHI-NEI-VFQ-25) was used to evaluate the vision-related quality of life in the SMILE group and the control group.Results In the SMILE group, the mean preoperative SE was -7.29±0.87 D (range -6.00 to -9.125 D). The efficacy index and safety index of SMILE were 1.09±0.18 and 1.19±0.12, respectively. Five years postoperatively, 44 eyes (73%) obtained a visual acuity of 20/20 or better. There were no eyes with CDVA loss of one or more Snellen lines. Forty-nine eyes (82%) and 57 eyes (95%) were within ±0.50 D and ±1.00 D of attempted correction, respectively. Forty-eight eyes (80%) had astigmatism < 0.50 D. The postoperative mean SE values at 3 months, 6 months, 1 year, and 5 years were 0.11±0.44 D, 0.07±0.45 D, -0.02±0.41 D, and -0.15±0.46 D, respectively. No significant change was observed in the ocular axial length from before operation to 5 years postoperatively (26.08±0.96 mm vs 26.01±0.94 mm, p>0.05). Compared to the control group, the SMILE group showed a significantly higher total score on the CHI-NEI-VFQ-25 (90.14 vs 81.43, p < 0.001).Conclusions In the present study, in a long-term follow-up, we demonstrated that correcting high myopia with SMILE is safe, effective, and predictable. In addition, there is slight undercorrection.


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