Pattern and distribution of neovascularization in proliferative diabetic retinopathy on fundus fluorescein angiography: A growing paradigm

2021 ◽  
Author(s):  
Mohini Agrawal ◽  
Aanchal Singhal ◽  
Poninder Kumar ◽  
Sumedha Vats ◽  
Jaya Kaushik ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Proliferative Diabetic Retinopathy ◽  
Fundus Fluorescein Angiography

FLUORESCEIN ANGIOGRAPHY OF EXTREME PERIPHERAL RETINA AND RUBEOSIS IRIDIS IN PROLIFERATIVE DIABETIC RETINOPATHY

Retina ◽  
1999 ◽  
Vol 19 (4) ◽  
pp. 302-308 ◽  
Author(s):  
HIROKO TERASAKI ◽  
YOZO MIYAKE ◽  
MASAKO MORI ◽  
TOSHIMITU SUZUKI ◽  
MINEO KONDO
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Proliferative Diabetic Retinopathy ◽  
Peripheral Retina ◽  
Rubeosis Iridis

scholarly journals Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoli Li ◽  
Jie Xie ◽  
Liang Zhang ◽  
Ying Cui ◽  
Guanrong Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Posterior Pole ◽  
Chinese Patients ◽  
Fundus Photography ◽  
Peripheral Retina ◽  
Multiple Logistic Regression ◽  
Fundus Fluorescein Angiography ◽  
Differential Distribution ◽  
Nonproliferative Diabetic Retinopathy

Abstract Background To analyze the distribution of manifest lesions of diabetic retinopathy (DR) by fundus fluorescein angiography (FFA) and color fundus photography (FP). Methods A total of 566 eyes of 324 Chinese patients diagnosed with DR were included in this retrospective study. DR severity was graded by the international grading criterion. The distributions of microaneurysms (MA), intraretinal hemorrhages/exudates (He/Ex), intraretinal microvascular abnormality (IRMA), capillary nonperfusion areas (NPA), and neovascularization (NV) were estimated by multiple logistic regression analyse based on nine-field FFA and FP images. Results In mild nonproliferative diabetic retinopathy (NPDR), the highest frequency of MA was found in the posterior pole (67.7%), followed by the inferior nasal (59.4%), and the nasal (55.4%) fields. In moderate NPDR, MA frequently distributed in the posterior pole (98.0%), nasal (97.0%), superior (96.0%), inferior nasal (94.9%), and inferior (92.9%) fields, whereas He/Ex were most prevalent in the posterior pole (69.7%). In severe NPDR and proliferative DR, IRMA, NPA, and NV were more frequent in the nasal field, particularly in the inferior nasal field (60.3, 38.7, and 76.0%, respectively). All lesions were more observed in the combined posterior pole, nasal, and inferior nasal fields than in the posterior pole or combined two fields in the early and severe stages of DR (P < 0.05). Conclusions The manifest lesions of DR were common in the nasal field besides the posterior pole in Chinese patients. A combined examination of the posterior pole, nasal, and inferior nasal mid-peripheral retina would help to detect different retinal lesions of DR. Trial registration ClinicalTrial. gov, NCT03528720. Registered 18 May 2018 - Retrospectively registered.

scholarly journals Role of Optical Coherence Tomography Angiography to differentiate Intraretinal microvascular abnormalities and retinal neovascularization in Diabetic Retinopathy

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Abdul Sami Memon ◽  
Nasir Ahmed Memon ◽  
Pir Salim Mahar
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Clinical Diagnosis ◽  
Proliferative Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Neovascularization ◽  
Wide Field ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography

Objective: To assess proliferative diabetic retinopathy (PDR) and to describe the difference in angiographic representation of new vessels (NVs) and Intra retinal microvascular abnormalities (IRMA) on optical coherence tomography angiography (OCTA). Methods: A cross-sectional observational study was performed at ISRA Postgraduate Institute of Ophthalmology, Karachi, from March 2018 to September 2018. Forty-two eyes of 21 patients with history of diabetes mellitus (DM) were examined. Twenty-eight eyes with a clinical diagnosis of severe non proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) according to early treatment diabetic retinopathy study (ETDRS) were included and evaluated using Swept source optical coherence tomography angiography (SS-OCTA). Then face wide field SS-OCTA images and co registered structural optical coherence tomography (OCT) with flow overlay were used to distinguish the features of IRMA and retinal NVs. Results: Forty-two eyes (21 patients) were examined clinically. Fourteen eyes had moderate NPDR, 15 had severe NPDR and 13 eyes had changes consistent with PDR. After clinical diagnosis, we included 28 eyes in our study based on inclusion criteria. These 28 eyes went through SS-OCTA evaluation and we observed 15 cases with PDR and 13 with severe NPDR changes. The OCTA and clinical diagnosis were similar except in 2 eyes, which is critical but not statically significant showing the importance of this noninvasive technology. Conclusions: Widefield OCTA can work as an alternative to fundus fluorescein angiography (FFA) in the diagnosis of diabetic retinopathy (DR). As it is a non-invasive and depth encoded technique so can be used frequently to monitor the retinal changes and their progression. doi: https://doi.org/10.12669/pjms.38.1.3891 How to cite this:Memon AS, Memon NA, Mahar PS. Role of Optical Coherence Tomography Angiography to differentiate Intraretinal microvascular abnormalities and retinal neovascularization in Diabetic Retinopathy. Pak J Med Sci. 2022;38(1):---------.  doi: https://doi.org/10.12669/pjms.38.1.3891 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Observation of Retinal Neovascularization using Optical Coherence Tomography Angiography after Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

2021 ◽  
Author(s):  
Feng He ◽  
Fangtian Dong ◽  
Weihong Yu
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Quantitative Information ◽  
Retinal Neovascularization ◽  
Prospective Clinical Study ◽  
Panretinal Photocoagulation ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography

Abstract Background: To describe the longitudinal changes of retinal neovascularization elsewhere (NVE) on optical coherence tomography angiography (OCTA) in proliferative diabetic retinopathy (PDR) treated by panretinal photocoagulation (PRP). Methods: Each patient included in this prospective clinical study was newly diagnosed PDR and NVE on both fundus fluorescein angiography (FFA) and OCTA. They received PRP of 4 sessions using multi-wavelength laser. Best-corrected visual acuity (BCVA) and OCTA images encompassing NVE were obtained before each PRP session and at 1 month, 3 months, and 6 months. Paired sample t-test was used to investigate differences between BCVA and NVE area before and after PRP. Results: Thirty-two eyes of 32 patients with a mean age of 50.56 ± 7.05 years were included. We found statistically significant reduction in the NVE size at all timepoints compared with the baseline except at 6 months (all P < 0.05). Further analysis demonstrated no statistically significant change of NVE size between two adjacent timepoints except from baseline to post-1st PRP and from 3 months to 6 months (both P < 0.05). BCVA at 3 months showed a statistically significant improvement compared with baseline (P < 0.05), but no significant changes of BCVA were observed during other visits.Conclusions: Using OCTA we found an overall regression in the NVE size following PRP starting as early as 1 week after 1st session and lasting until 3 months. OCTA provides quantitative information of vascular changes and could be a practical method for the longitudinal evaluation of neovascularization.

Medical retina

2012 ◽  
Author(s):  
Bheema Patil ◽  
Pankaj Puri
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Visual Loss ◽  
Clinical Skills ◽  
Night Vision ◽  
Age Related Macular Degeneration ◽  
Hypertensive Retinopathy ◽  
Fundus Fluorescein Angiography ◽  
Macular Lesion ◽  
Age Related

The chapter begins by discussing key clinical skills, namely fundus fluorescein angiography, abnormal fluorescein angiography, indocyanine green angiography, and electrophysiology. The following areas of clinical knowledge are then discussed: diabetic retinopathy, hypertensive retinopathy, retinal vein occlusion, retinal artery occlusions, age-related macular degeneration, intravitreal anti-VEGF injections, central serous chorioretinopathy, retinal vascular anomalies, retinal dystrophies, and choroidal dystrophies. The chapter concludes with eight case-based discussions, on gradual visual loss, central visual loss, visual loss in a hypertensive patient, sudden, painless visual loss, diabetic retinopathy, difficult night vision, visual loss in child, and macular lesion.

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