Asthma control using fluticasone propionate/salmeterol in Asian and non-Asian populations: a post hoc analysis of the GOAL study

(1) Background: Monthly variability in smoking behaviors in caregivers of pediatric asthmatics yields questions of how much and when does smoking reduction result in improved environmental and clinical outcomes. (2) Methods: Post hoc analysis of data from a 6 month pilot randomized-control trial occurring from May 2017 to May 2018 in Baltimore City (MD, USA). The initial trial’s primary intervention explored the utility of financial incentives in modifying caregiver smoking behaviors. Post hoc analyses examined all dyads independent of the initial trial’s randomization status. All caregivers received pediatric tobacco smoke harm reduction education, in addition to monthly encouragement to access the state tobacco quitline for individual phone-based counseling and nicotine replacement therapy. Maternal caregivers who were active cigarette smokers and their linked asthmatic child (aged 2–12 years) were grouped into two classifications (“high” versus “low”) based on the child and caregiver’s cotinine levels. A “low” cotinine level was designated by at least a 25% reduction in cotinine levels during 3 months of the trial period; achieving ≤2 months of low cotinine levels defaulted to the “high” category. Twenty-seven dyads (caregivers and children) (total n = 54) were assigned to the “high” category, and eighteen dyads (caregivers and children) (total n = 36) were allocated to the “low” category. The primary outcome measure was the correlation of caregiver cotinine levels with pediatric cotinine values. Secondary outcomes included asthma control, in addition to caregiver anxiety and depression. (3) Results: Caregivers with 3 months of ≥25% decrease in cotinine levels had a significantly greater mean change in child cotinine levels (p = 0.018). “Low” caregiver cotinine levels did not significantly improve pediatric asthma control (OR 2.12 (95% CI: 0.62–7.25)). Caregiver anxiety and depression outcomes, measured by Patient Health Questionnaire (PHQ)-4 scores, was not significantly different based on cotinine categorization (p = 0.079); (4) Conclusion: Reduced pediatric cotinine levels were seen in caregivers who reduced their smoking for at least 3 months, but clinical outcome measures remained unchanged.

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Efficacy of MP-AzeFlu versus fluticasone propionate and azelastine in patients with allergic rhinitis and nasal hyperreactivity: A post hoc analysis from three clinical trials

10.26226/morressier.5acc8ad0d462b8028d89add3 ◽

2018 ◽

Author(s):

Peter Hellings

Keyword(s):

Clinical Trials ◽

Allergic Rhinitis ◽

Fluticasone Propionate ◽

Post Hoc Analysis ◽

Nasal Hyperreactivity ◽

Post Hoc

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Post Hoc Analysis of a Budesonide/Formoterol Pressurized Metered-Dose Inhaler (BUD/FM pMDI) Study: Asthma Control and Study Withdrawal in Patients With Mild to Moderate Asthma With Versus Without Fixed Airflow Obstruction Defined Using 2 Different Criteria

CHEST Journal ◽

10.1378/chest.1386417 ◽

2012 ◽

Vol 142 (4) ◽

pp. 700A

Author(s):

Bradley Chipps ◽

Donald Tashkin ◽

Tom Uryniak ◽

Frank Trudo ◽

James Zangrilli

Keyword(s):

Asthma Control ◽

Airflow Obstruction ◽

Dose Inhaler ◽

Metered Dose Inhaler ◽

Moderate Asthma ◽

Post Hoc Analysis ◽

Metered Dose ◽

Pressurized Metered Dose Inhaler ◽

Post Hoc ◽

Fixed Airflow Obstruction

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Non-cardioembolic stroke/transient ischaemic attack in Asians and non-Asians: A post-hoc analysis of the PERFORM study

European Stroke Journal ◽

10.1177/2396987318797245 ◽

2018 ◽

Vol 4 (1) ◽

pp. 65-74 ◽

Cited By ~ 1

Author(s):

Takao Hoshino ◽

Leila Sissani ◽

Julien Labreuche ◽

Marie-Germaine Bousser ◽

Angel Chamorro ◽

...

Keyword(s):

Transient Ischaemic Attack ◽

Cardiovascular Events ◽

Cardioembolic Stroke ◽

Major Adverse Cardiovascular Events ◽

Lacunar Stroke ◽

Post Hoc Analysis ◽

Asian Populations ◽

Asian Patients ◽

Ischaemic Attack ◽

Post Hoc

Introduction We aimed to compare the characteristics and vascular outcomes between Asian and non-Asian patients with non-cardioembolic stroke/transient ischaemic attack receiving antiplatelet monotherapy and to identify population-specific predictors for recurrent events. Patients and methods We conducted a post-hoc analysis of data from the PERFORM study, in which 19,100 patients (mean age, 67.2 years; male, 63%; 2178 Asian and 16,922 non-Asian patients) with non-cardioembolic ischaemic stroke/transient ischaemic attack were randomised to aspirin or terutroban and followed for two years. The primary outcome was a composite of major adverse cardiovascular events (non-fatal myocardial infarction, non-fatal stroke and cardiovascular death). Results There was no difference in major adverse cardiovascular events risk between Asian and non-Asian populations (11.1% vs. 10.5%; p = 0.39). However, Asian patients were at significantly higher risk of intracranial haemorrhage (2.4% vs. 1.3%; hazard ratio (HR) 1.87; 95% confidence interval (CI) 1.34–2.60; p < 0.001) and major bleeding (5.4% vs. 4.1%; HR 1.30; 95% CI 1.04–1.61; p = 0.02). Stroke risk was significantly higher in Asian than in non-Asian populations among patients with lacunar stroke (7.4% vs. 4.5%; p = 0.02). In multivariable analysis, diastolic blood pressure (HR per 5 mm Hg 1.08; 95% CI 1.01–1.16; p = 0.03) and diabetes (HR 1.36; 95% CI 1.22–1.52; p < 0.001) were independent predictors of major adverse cardiovascular events for Asian and non-Asian patients, respectively. Conclusion: Compared with non-Asian patients, Asian patients had significantly higher risk of haemorrhagic events when given antiplatelet monotherapy for secondary prevention after non-cardioembolic stroke/transient ischaemic attack. Lacunar stroke and elevated diastolic blood pressure were more associated with recurrence risk in Asian patients.

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