scholarly journals Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjögren’s syndrome

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Hideki Nakamura ◽  
Toshimasa Shimizu ◽  
Yukinori Takagi ◽  
Yoshiko Takahashi ◽  
Yoshiro Horai ◽  
...  
2021 ◽  
pp. 1-11
Author(s):  
Hideki Nakamura ◽  
Shimpei Morimoto ◽  
Toshimasa Shimizu ◽  
Ayuko Takatani ◽  
Shin-ya Nishihata ◽  
...  

2018 ◽  
Vol 13 (3-4) ◽  
pp. 81-87
Author(s):  
D.V. Topchy

Relevance. Sjogren's syndrome is included in the group of diffuse connective tissue diseases and ranks third among them. Sjögren's syndrome remains unidentified in half the cases of the disease with clinical manifestations. Diagnosis of Sjogren's syndrome in some cases has serious difficulties, which is due to both large polymorphism of Sjogren's syndrome and insufficient awareness of practical doctors in the clinic and diagnosis of this disease. Objective is to generalize the literature data on the possibilities of using radiation methods for early diagnosis of Sjogren's syndrome. Materials and methods. The literature sources on the possibility of using sialography, ultrasound examination, scintigraphy, magnetic resonance tomography of the salivary glands in the diagnosis of Sjogren's syndrome are analyzed. Data on the use of radiation diagnostics methods for revealing the initial signs of the disease, for assessing prevalence, for studying the salivary gland vascularization, for differential diagnosis of Sjogren's syndrome with sialadenitis and sialozema are presented. Results. Most authors consider sialografy to be a highly informative technique, which helps to identify symptoms in Sjogren's syndrome. In the ultrasound study, the authors determine the bilateral increase in the size of the parotid salivary glands. The advantage of scintigraphy of salivary glands in comparison with other methods is that the functions of all four major salivary glands (parotid and submaxillary) can be simultaneously evaluated with the help of a single injection of the isotope 99-m Tc-pertechnetate. Conclusion. In the presence of technical equipment, a comprehensive examination using methods of radiation diagnosis in case of suspicion of Sjogren's syndrome can become an origin of early, accurate and practically meaningful information.


2021 ◽  
Vol 11 ◽  
Author(s):  
Huimin Zhou ◽  
Jun Yang ◽  
Jie Tian ◽  
Shengjun Wang

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4+ T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8+ T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8+ T lymphocytes, specifically describing the role of CD8+ T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8+ T cells to capitalize on the pathogenic and regulatory potential of CD8+ T lymphocytes in SS to provide promising new strategies for this inflammatory disease.


1995 ◽  
Vol 53 (4) ◽  
pp. 777-781 ◽  
Author(s):  
Sônia Regina A. A. Pinheiro ◽  
Marco Aurélio Lana-Peixoto ◽  
Anna B. Carneiro Proietti ◽  
Fernando Oréfice ◽  
Maria V. Lima-Martins ◽  
...  

A 62 year-old white female presented with a 10-year-history of slowly progressive spastic paraparesis, pain and dysesthesia in the lower limbs and sphincter disturbance. A few years after the onset of the neurologic symptoms she developped migratory arthritis with swelling of the knees and pain on palpation of knees and fingers, dry eyes, mouth and skin. Two months before admission she presented bilateral nongranulomatous anterior uveitis. Examination revealed spastic paraparesis with bilateral Babinski sign, a decreased sensation level below L3, decreased vibration sense in the lower extremities, and a postural tremor of the upper limbs. Laboratory work-up disclosed HTLV-I positive tests in the blood and cerebrospinal fluid (CSF), and a mild pleocytosis in the CSF with a normal protein content. Nerve conduction velocity studies were normal. The present case shows the association of uveitis, arthritis and Sjögren's syndrome in a patient with tropical spastic paraparesis / human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy (TSP/HAM), and illustrates the wide spectrum of clinical manifestations which may accompany this infection with this virus.


Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq

Epidemiology and pathology 354 Clinical manifestations of Sjögren's syndrome 356 Investigation of Sjögren's syndrome 360 Treatment of Sjögren's syndrome 362 • Sjögren's syndrome (SS) is a chronic autoimmune disease of unknown aetiology, characterized by lymphocyte infiltration of exocrine glands resulting in xerostomia and keratoconjunctivitis sicca....


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