scholarly journals HTLV-I Associated uveitis, myelopathy, rheumatoid arthritis and Sjögren's syndrome

1995 ◽  
Vol 53 (4) ◽  
pp. 777-781 ◽  
Author(s):  
Sônia Regina A. A. Pinheiro ◽  
Marco Aurélio Lana-Peixoto ◽  
Anna B. Carneiro Proietti ◽  
Fernando Oréfice ◽  
Maria V. Lima-Martins ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Spastic Paraparesis ◽  
Clinical Manifestations ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Lower Limbs ◽  
Type I ◽  
Human T Cell ◽  
Sjögren‘S Syndrome

A 62 year-old white female presented with a 10-year-history of slowly progressive spastic paraparesis, pain and dysesthesia in the lower limbs and sphincter disturbance. A few years after the onset of the neurologic symptoms she developped migratory arthritis with swelling of the knees and pain on palpation of knees and fingers, dry eyes, mouth and skin. Two months before admission she presented bilateral nongranulomatous anterior uveitis. Examination revealed spastic paraparesis with bilateral Babinski sign, a decreased sensation level below L3, decreased vibration sense in the lower extremities, and a postural tremor of the upper limbs. Laboratory work-up disclosed HTLV-I positive tests in the blood and cerebrospinal fluid (CSF), and a mild pleocytosis in the CSF with a normal protein content. Nerve conduction velocity studies were normal. The present case shows the association of uveitis, arthritis and Sjögren's syndrome in a patient with tropical spastic paraparesis / human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy (TSP/HAM), and illustrates the wide spectrum of clinical manifestations which may accompany this infection with this virus.

Detection of HTLV-1 in the Labial Salivary Glands of Patients with Sjögren’s Syndrome: A Distinct Clinical Subgroup?

2012 ◽  
Vol 39 (4) ◽  
pp. 809-815 ◽  
Author(s):  
SUNG-JI LEE ◽  
JI SHIN LEE ◽  
MYUNG-GEUN SHIN ◽  
YUETSU TANAKA ◽  
DONG-JIN PARK ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Type I ◽  
Extraglandular Manifestations ◽  
Human T Cell ◽  
Sjögren‘S Syndrome

Objective.To examine whether patients with Sjögren’s syndrome (SS) can be distinguished based on the expression of human T cell lymphotrophic virus type I (HTLV-1) and, if so, whether the subgroups differ in their clinical features and serological measures.Methods.Polymerase chain reaction (PCR) and nested PCR were used to amplify viral DNA from peripheral blood mononuclear cells (PBMC) in 53 patients with SS, using primers from the HTLV-1 pX, p19, pol, and tax regions. Minor salivary gland biopsy specimens from 33 patients with SS were examined for the presence of HTLV-1 p19 or tax proteins immunohistochemically. The sociodemographic, glandular, and extraglandular manifestations, and laboratory findings including autoantibodies, complement, and immunoglobulin levels, were analyzed.Results.The HTLV-1 tax gene was detected in PBMC samples from 2 of 53 patients (3.8%), whereas the HTLV-1 pX, p19, and pol genes were not expressed. As well, 100% of PBMC samples from 4 family members of patients in whom the tax gene was detected also expressed the tax gene. Immunohistochemical staining for HTLV-1 p19 and tax was seen in 10 out of 33 (30.3%) patients with SS each. Overall, 14 (42.4%) patients expressed HTLV-1 p19 or tax proteins, and they had lower rheumatoid factor and C3 levels (p = 0.015 and p = 0.005, respectively) and higher lymphocyte counts (p = 0.016). The prevalence of glandular and extraglandular manifestations did not differ between the HTLV-1-positive and negative patients.Conclusion.Our findings suggest that HTLV-1 in the salivary glands is involved in the pathogenesis of a subpopulation of SS, and HTLV-1-associated SS might have different immunological patterns than idiopathic SS.

scholarly journals Clinical manifestations in anti-Ro52/SS-a antibody-seropositive patients with Sjögren's syndrome

2021 ◽  
pp. 1-11
Author(s):  
Hideki Nakamura ◽  
Shimpei Morimoto ◽  
Toshimasa Shimizu ◽  
Ayuko Takatani ◽  
Shin-ya Nishihata ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Clinical Manifestations ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjögren’s syndrome

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Hideki Nakamura ◽  
Toshimasa Shimizu ◽  
Yukinori Takagi ◽  
Yoshiko Takahashi ◽  
Yoshiro Horai ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Clinical Manifestations ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Maria Giovanna Danieli ◽  
Lucia Pettinari ◽  
Ramona Morariu ◽  
Fernando Monteforte ◽  
Francesco Logullo
Keyword(s):  
Mycophenolate Mofetil ◽  
Intravenous Immunoglobulin ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Lower Limbs ◽  
High Dose ◽  
Sensory Neuronopathy ◽  
Sjögren‘S Syndrome

Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy.

scholarly journals Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052097446 ◽  
Author(s):  
Huijia Yang ◽  
Xiaozhong Jing ◽  
Jinhua Yan ◽  
Dihui Ma
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Lower Limbs ◽  
Weekly Dose ◽  
Limb Weakness ◽  
Sjögren‘S Syndrome

Sjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome. A 42-year-old woman was admitted to our hospital with a 2-month history of progressive limb weakness. Neurological assessment revealed fasciculation in the lower limbs and amyotrophy in the bilateral supraspinatus, interosseous, and thenar muscles. Serological examination and labial gland biopsy revealed Sjögren’s syndrome. In addition, electromyography demonstrated neurogenic damage to the upper and lower limbs. The patient received a short course of high-dose corticosteroids, intravenous immunoglobulins, and immunosuppressant treatment, including a weekly dose of 0.4 g cyclophosphamide and a daily dose of 0.2 g hydroxychloroquine. However, the patient’s limb weakness was further aggravated and her respiratory function was compromised. Electromyography re-examination demonstrated extensive neurogenic damage, and she was diagnosed with Sjögren’s syndrome with motor neuron disease. The patient died of respiratory failure after 2 months. We suggest that more effective maintenance treatments should be sought. Further investigation is required to elucidate the association between autoimmune motor neuron disease and Sjögren’s syndrome.

Prevalence of Sjögren's syndrome in Brazilian patients infected with human T-cell lymphotropic virus

2016 ◽  
Vol 46 (7) ◽  
pp. 543-548 ◽  
Author(s):  
Daniela Assis do Vale ◽  
Jorge Casseb ◽  
Augusto César Penalva de Oliveira ◽  
Ivo Bussoloti Filho ◽  
Suzana Cantanhede Orsini Machado de Sousa ◽  
...  
Keyword(s):  
T Cell ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Human T Cell ◽  
Sjögren‘S Syndrome

scholarly journals Type I interferons in Sjögren's syndrome

2013 ◽  
Vol 12 (5) ◽  
pp. 558-566 ◽  
Author(s):  
Yihong Yao ◽  
Zheng Liu ◽  
Bahija Jallal ◽  
Nan Shen ◽  
Lars Rönnblom
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Type I Interferons ◽  
Type I ◽  
Sjögren‘S Syndrome
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