scholarly journals CD8+ T Lymphocytes: Crucial Players in Sjögren’s Syndrome

2021 ◽  
Vol 11 ◽  
Author(s):  
Huimin Zhou ◽  
Jun Yang ◽  
Jie Tian ◽  
Shengjun Wang
Keyword(s):  
T Lymphocytes ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eyes ◽  
Multiple Organs ◽  
Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4+ T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8+ T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8+ T lymphocytes, specifically describing the role of CD8+ T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8+ T cells to capitalize on the pathogenic and regulatory potential of CD8+ T lymphocytes in SS to provide promising new strategies for this inflammatory disease.

scholarly journals Clinical manifestations in anti-Ro52/SS-a antibody-seropositive patients with Sjögren's syndrome

2021 ◽  
pp. 1-11
Author(s):  
Hideki Nakamura ◽  
Shimpei Morimoto ◽  
Toshimasa Shimizu ◽  
Ayuko Takatani ◽  
Shin-ya Nishihata ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Clinical Manifestations ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjögren’s syndrome

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Hideki Nakamura ◽  
Toshimasa Shimizu ◽  
Yukinori Takagi ◽  
Yoshiko Takahashi ◽  
Yoshiro Horai ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Clinical Manifestations ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

Therapeutic Effect of Mesenchymal Stem Cells on Sjögren's Syndrome: Systematic Review and a Preclinical Meta-Analysis

2021 ◽  
Author(s):  
Yan Liu ◽  
Yi Xiong Chen ◽  
Nancy Olsen ◽  
Wael Jarjour ◽  
Yan Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Therapeutic Effects ◽  
Sjögren‘S Syndrome

Abstract BackgroundEvidence to support Mesenchymal stem cells (MSCs) treatment in Sjögren's syndrome (SS) has been verified. This study aims to evaluate the effectiveness of heterogeneous MSCs therapies, identify optimal experimental parameters and explore possible underlying mechanisms in animal models of SS.MethodsLiterature searches were performed in PubMed, Web of Science and EMBASE. Effect sizes of SS treatments with MSCs were extracted and analyzed by two authors independently.ResultsA total of 13 studies and 20 treatment arms met the inclusion criteria. When compared with the controls, MSCs treatment resulted in lower level of histological score (SMD= -2.208; 95%CI= -3.129, -1.286; P<0.001) accompanied by an improved trend of salivary flow rate (SFR) (SMD = 1.726; 95%CI= 1.340, 2.113; P <0.001) and Schirmer's test results (SMD= 3.379; 95% CI= 2.141, 4.618; P<0.001). In MSCs groups, levels of autoantibodies decreased to varying degrees. Treg cells were increased and Th17 cells were decreased in both lymph nodes and spleens. Additionally, IL-6 reduction and IL-10 elevation were found in local lesional tissues. Furthermore, TNF-α level dropped either in sera or glands. Notably, the cell injection frequency and routes may be two important factors affecting the effect of MSCs therapy.ConclusionTo the best of our knowledge, this is the first meta-analysis to quantitatively evaluate MSCs therapeutic effects on SS. Our research emphasizes optimizing MSC treatment strategies to achieve better outcomes, thereby providing a valuable reference for clinical application.

scholarly journals Discrimination between Sjögren's and Non-Sjögren's Sicca Syndrome by Sialoscintigraphy and Antibodies against α-Fodrin and Ro/La Autoantigens

2009 ◽  
Vol 37 (4) ◽  
pp. 1088-1096 ◽  
Author(s):  
K-S Chen ◽  
M-C Jiang ◽  
C-J Li ◽  
O-K Liu ◽  
C-SS Tsai
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sicca Syndrome ◽  
Dry Eyes ◽  
Sicca Symptoms ◽  
Grade Iii ◽  
Sjögren‘S Syndrome

Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens α-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were α-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum α-fodrin, Ro and La might be useful for SS and NSS discrimination.

scholarly journals MANAGEMENT OF SJOGREN'S SYNDROME THROUGH AYURVEDA : A CASE STUDY

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dr Raja Singla ◽  
Dr Harish Kumar
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Autoimmune Disorder ◽  
Lymphocytic Infiltration ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Exocrine Glands ◽  
Dry Eyes ◽  
Sjögren‘S Syndrome

Sjögren's syndrome is a chronic, slowly progressing autoimmune disorder characterised by lymphocytic infiltration of exocrine glands resulting in xerostomia and dry eyes (conjunctivitis). 1) The disease can present as an entity alone or in association with other auto-immune diseases like Scleroderma, RA, SLE & auto-immune thyroid disease. 2) In this article, attempt is made to understand the Sjögren's syndrome & its treatment in ayurveda by considering the concept of udakvaha srotodushti, vyadhikshamatva and vatadhikya vatrakta. Keywords:Auto-immune, Vatadhikya Vatrakta, Sjögren's syndrome, Udakvaha srotodushti

scholarly journals DIAGNOSIS OF THE SYNDROME OF SCHEGREN. REVIEW

2018 ◽  
Vol 13 (3-4) ◽  
pp. 81-87
Author(s):  
D.V. Topchy
Keyword(s):  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Connective Tissue Diseases ◽  
Clinical Manifestations ◽  
Magnetic Resonance Tomography ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Technical Equipment ◽  
Sjögren‘S Syndrome

Relevance. Sjogren's syndrome is included in the group of diffuse connective tissue diseases and ranks third among them. Sjögren's syndrome remains unidentified in half the cases of the disease with clinical manifestations. Diagnosis of Sjogren's syndrome in some cases has serious difficulties, which is due to both large polymorphism of Sjogren's syndrome and insufficient awareness of practical doctors in the clinic and diagnosis of this disease. Objective is to generalize the literature data on the possibilities of using radiation methods for early diagnosis of Sjogren's syndrome. Materials and methods. The literature sources on the possibility of using sialography, ultrasound examination, scintigraphy, magnetic resonance tomography of the salivary glands in the diagnosis of Sjogren's syndrome are analyzed. Data on the use of radiation diagnostics methods for revealing the initial signs of the disease, for assessing prevalence, for studying the salivary gland vascularization, for differential diagnosis of Sjogren's syndrome with sialadenitis and sialozema are presented. Results. Most authors consider sialografy to be a highly informative technique, which helps to identify symptoms in Sjogren's syndrome. In the ultrasound study, the authors determine the bilateral increase in the size of the parotid salivary glands. The advantage of scintigraphy of salivary glands in comparison with other methods is that the functions of all four major salivary glands (parotid and submaxillary) can be simultaneously evaluated with the help of a single injection of the isotope 99-m Tc-pertechnetate. Conclusion. In the presence of technical equipment, a comprehensive examination using methods of radiation diagnosis in case of suspicion of Sjogren's syndrome can become an origin of early, accurate and practically meaningful information.

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