scholarly journals Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shangqing Ren ◽  
Hualin Feng ◽  
Yige Bao ◽  
Yi Wei ◽  
Yong Ou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standard Treatment ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Upper Urinary Tract ◽  
Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

scholarly journals TWO CASES OF SQUAMOUS CELL CARCINOMA OF UPPER URINARY TRACT WITH HYPERCALCEMIA

2008 ◽  
Vol 99 (6) ◽  
pp. 703-708
Author(s):  
Satoshi Washino ◽  
Fumihito Terauchi ◽  
Atsushi Matsuzaki ◽  
Yutaka Kobayashi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Upper Urinary Tract

Selective Immunohistochemical Markers to Distinguish Between Metastatic High-Grade Urothelial Carcinoma and Primary Poorly Differentiated Invasive Squamous Cell Carcinoma of the Lung

2012 ◽  
Vol 136 (11) ◽  
pp. 1339-1346 ◽  
Author(s):  
Aaron M. Gruver ◽  
Mahul B. Amin ◽  
Daniel J. Luthringer ◽  
Danielle Westfall ◽  
Komal Arora ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Positive Staining ◽  
Invasive Squamous Cell Carcinoma ◽  
Metastatic Urothelial Carcinoma ◽  
Poorly Differentiated ◽  
Desmoglein 3

Context.—Distinction between primary lung carcinomas and metastases from other sites, especially the urinary tract, is a common diagnostic dilemma. As urothelial carcinomas can demonstrate a broad range of morphology and frequently demonstrate squamous differentiation, discerning metastatic urothelial carcinoma to the lung from primary pulmonary squamous cell carcinoma can be challenging. Objective.—To investigate immunostains that may aid in the distinction of urothelial carcinoma metastatic to the lung. Design.—Staining patterns of 14 markers in primary urothelial carcinoma of the bladder and primary squamous cell carcinoma of the lung were examined to establish a diagnostic panel. These antibodies were subsequently tested on tumors taken from 30 patients with a paired urinary tract and metastatic lung lesion. Results.—The best markers to distinguish poorly differentiated metastatic urothelial carcinoma from primary pulmonary squamous cell carcinoma were CK7, CK20, GATA-3, CK14, desmoglein-3, and uroplakin III, with the utility of the latter dependent upon the quantity of tissue available for analysis. The observed percentage positive staining in nonmetastatic urothelial carcinoma versus primary pulmonary squamous cell carcinoma with these antibodies was as follows: CK7 (100% versus 33%), CK20 (54% versus 7%), GATA-3 (78% versus 23%), CK14 (32% versus 77%), desmoglein-3 (11% versus 87%), and uroplakin III (14% versus 0%). Similar expression patterns were observed among the paired cases. Conclusion.—When interpreted in correlation with clinical history and histomorphology, a panel of immunostains including CK7, CK20, GATA-3, CK14, desmoglein-3, and uroplakin III may be a useful adjunct in the distinction of metastatic urothelial carcinoma to the lung.

scholarly journals Misdiagnosis of laryngeal sarcomatoid squamous cell carcinoma – case report

2015 ◽  
Vol 5 (17) ◽  
pp. 53-57
Author(s):  
Irén Csiszér ◽  
Simona Mocanu ◽  
Vlad Budu ◽  
Adriana Neagos
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sleep Apnea Syndrome ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Complex Case ◽  
Selective Neck Dissection ◽  
Microscopic Appearance

Abstract BACKGROUND. Even if it is a rare variant growth pattern of squamous cell carcinoma, sarcomatoid carcinoma seems to have almost the same clinical manifestations and risk factors as conventional squamous cell carcinoma. CASE REPORT. This paper presents a complex case of a 59-year-old female patient known with laryngeal papillomatosis, who presented in our Department for moderate to severe inspiratory dyspnea associated with dysphonia and difficulty in swallowing. We mention that the patient had been previously evaluated by a pneumologist for apnea, snoring and daytime sleepiness and diagnosed and treated for sleep apnea syndrome. Clinical, laboratory, imaging and pathologic examinations revealed the association of upper airway obstruction with laryngeal cancer. Surgical intervention consisted in total laryngectomy and selective neck dissection associated with permanent tracheotomy. The microscopic appearance was that of a bilateral transglottic sarcomatoid squamous cell carcinoma without metastasis in the right lymph node. CONCLUSION. It is important to evaluate the clinical and imagistic status of patients with laryngeal tumors in order to make a correct decision concerning their treatment policy. We emphasize that cooperation between multiple departments is absolutely necessary in order to adequately resolve, explore, diagnose and treat patients with laryngeal pathology.

scholarly journals Primary Renal Squamous Cell Carcinoma: An Unusual Malignancy

2019 ◽  
Vol 8 (1) ◽  
pp. 50-53
Author(s):  
Huma Mushtaq ◽  
Naima Tariq ◽  
Tehreem Atif ◽  
Saeed Alam ◽  
Mumtaz Ahmed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Reports ◽  
Left Kidney ◽  
Upper Urinary Tract ◽  
Male Resident ◽  
Renal System ◽  
Azad Kashmir

Malignancies of the upper urinary tract are rare, accounting for about 8% of all malignancies of the renal system, presenting mostly as urothelial carcinoma. Squamous cell carcinoma (SCC) arising from the upper urinary tract is even more rare, accounting for about 0.5% of all malignancies of the renal system and 10% of all renal pelvic tumors. There are very few case reports in the indexed literature regarding renal squamous cell carcinoma. Here we present a case of SCC arising from the lower pole of left kidney, in a 35-year-old male resident of Muzaffarabad, Azad Kashmir.

scholarly journals Treatment of primary squamous cell carcinoma of the upper urinary tract

Cancer ◽  
1991 ◽  
Vol 68 (12) ◽  
pp. 2575-2578 ◽  
Author(s):  
Ofer Nativ ◽  
Herbert M. Reiman ◽  
Michael M. Lieber ◽  
Horst Zincke
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Upper Urinary Tract ◽  
Primary Squamous Cell Carcinoma

scholarly journals Rare case of upper urinary tract squamous cell carcinoma presenting with significant paraneoplastic syndrome

2020 ◽  
Vol 12 (4) ◽  
pp. 388
Author(s):  
SandraS.Y. Kim ◽  
RicardoA Rendon ◽  
Myuran Thana ◽  
Lori Wood ◽  
Cheng Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Paraneoplastic Syndrome ◽  
Rare Case ◽  
Upper Urinary Tract
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