scholarly journals Performance characteristics of prostate-specific antigen density and biopsy core details to predict oncological outcome in patients with intermediate to high-risk prostate cancer underwent robot-assisted radical prostatectomy

BMC Urology ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Masahiro Yashi ◽  
Akinori Nukui ◽  
Yuumi Tokura ◽  
Kohei Takei ◽  
Issei Suzuki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Specific Antigen ◽  
Oncological Outcome ◽  
Robot Assisted ◽  
High Risk Prostate Cancer ◽  
Biopsy Core ◽  
Prostate Specific Antigen Density ◽  
Risk Prostate Cancer

scholarly journals Phase III Intergroup Trial of Adjuvant Androgen Deprivation With or Without Mitoxantrone Plus Prednisone in Patients With High-Risk Prostate Cancer After Radical Prostatectomy: SWOG S9921

2018 ◽  
Vol 36 (15) ◽  
pp. 1498-1504 ◽  
Author(s):  
Maha Hussain ◽  
Catherine M. Tangen ◽  
Ian M. Thompson ◽  
Gregory P. Swanson ◽  
David P. Wood ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Specific Antigen ◽  
Androgen Deprivation ◽  
Hazard Ratio ◽  
Phase Iii ◽  
Adjuvant Radiation ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Purpose Patients with high-risk prostate cancer after radical prostatectomy are at risk for death. Adjuvant androgen-deprivation therapy (ADT) may reduce this risk. We hypothesized that the addition of mitoxantrone and prednisone (MP) to adjuvant ADT could reduce mortality compared with adjuvant ADT alone. Methods Eligible patients had cT1-3N0 prostate cancer with one or more high-risk factors after radical prostatectomy (Gleason score [GS] ≥ 8; pT3b, pT4, or pN+ disease; GS 7 and positive margins; or preoperative prostate-specific antigen [PSA] > 15 ng/mL, biopsy GS score > 7, or PSA > 10 ng/mL plus biopsy GS > 6. Patients with PSA ≤ 0.2 ng/mL after radical prostatectomy were stratified by pT/N stage, GS, and adjuvant radiation plan and randomly assigned to ADT (bicalutamide and goserelin for 2 years) or ADT plus six cycles of MP. The primary end point was overall survival (OS). Median OS was projected to be 10 years in the ADT arm, requiring 680 patients per arm to detect a hazard ratio of 1.30 with 92% power and one-sided α = .05. Results Nine hundred sixty-one eligible intent-to-treat patients were randomly assigned to ADT or ADT + MP from October 1999 to January 2007, when the Data Safety Monitoring Committee recommended stopping accrual as a result of higher leukemia incidence with ADT + MP. Median follow-up was 11.2 years. The 10-year OS estimates were 87% with ADT (expected 50%) and 86% with ADT + MP (hazard ratio, 1.06; 95% CI, 0.79 to 1.43). The 10-year estimate for disease-free survival was 72% for both arms. Prostate cancer was the cause of death in 18% of patients in the ADT arm and 22% in the ADT + MP arm. More patients in the MP arm died of other cancers (36% v 18% in ADT alone arm). Conclusion MP did not improve OS and increased deaths from other malignancies. The DFS and 10-year OS in these patients treated with 2 years of ADT were encouraging compared with historical estimates, although a definitive conclusion regarding value of ADT may not be made without a nontreatment control arm.

1058 Functional outcomes with robot assisted radical prostatectomy (RALP) in preoperatively high risk prostate cancer patients

2012 ◽  
Vol 11 (1) ◽  
pp. e1058-e1058a
Author(s):  
A. Sivaraman ◽  
V. Patel ◽  
K. Palmer ◽  
R. Coelho ◽  
S. Chauhan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Functional Outcomes ◽  
Robot Assisted ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

26 Robot assisted radical prostatectomy in low- and high-risk prostate cancer patients: Who would benefit most?

2015 ◽  
Vol 14 (8) ◽  
pp. e1360
Author(s):  
U. Boylu ◽  
A. Bindayi ◽  
A. Tahra ◽  
E.V. Kucuk ◽  
F.F. Onol ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Robot Assisted ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Safety of selective nerve sparing in high risk prostate cancer during robot-assisted radical prostatectomy

2016 ◽  
Vol 11 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Anup Kumar ◽  
Srinivas Samavedi ◽  
Anthony S. Bates ◽  
Vladimir Mouraviev ◽  
Rafael F. Coelho ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Nerve Sparing ◽  
Robot Assisted ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer
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