scholarly journals MicroRNA miR-466 inhibits Lymphangiogenesis by targeting prospero-related homeobox 1 in the alkali burn corneal injury model

2015 ◽  
Vol 22 (1) ◽  
pp. 3 ◽  
Author(s):  
Minkoo Seo ◽  
Jun-Sub Choi ◽  
Chang Rho ◽  
Choun-Ki Joo ◽  
Suk Lee
Niche Journal ◽  
2014 ◽  
Vol 2 (2) ◽  
pp. 18-21
Author(s):  
Ugur Acar ◽  
Emrullah Beyazyildiz ◽  
Ferda Alpaslan Pinarli ◽  
Ali Bulent Cankaya ◽  
Ozdemir Ozdemir ◽  
...  

Author(s):  
Kun Zhang ◽  
Miao-Yu Guo ◽  
Qiu-Gen Li ◽  
Xiao-Hua Wang ◽  
Yu-Ying Wan ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Shanshan Wan ◽  
Wanju Yang ◽  
Yumiao Pan ◽  
Zhuoqun Rao ◽  
Yanning Yang

Background. G9a, a well-known methyltransferase, plays a vital role in biological processes. However, its role in corneal neovascularization (CoNV) remains unclear. Methods. In vitro and in vivo models were assessed in hypoxia-stimulated angiogenesis and in a mouse model of alkali burn-induced CoNV. Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic conditions and different reoxygenation times to identify the molecular mechanisms involved in this process. Results. In this study, we found that G9a was positively related to corneal alkali burn-induced injury. Inhibition of G9a with BIX 01294 (BIX) alleviated corneal injury, including oxidative stress and neovascularization in vivo. Similarly, inhibition of G9a with either BIX or small interfering RNA (siRNA) exerted an inhibitory effect on hypoxia/reoxygenation (H/R)-induced oxidative stress and angiogenesis in HUVECs. Moreover, our study revealed that ablation of reactive oxygen species (ROS) with N-acetyl-cysteine suppressed angiogenesis in HUVECs exposed to H/R stimulation. Furthermore, NADPH oxidase 4 (Nox4), which was positively associated with ROS production and angiogenesis, was elevated during H/R. This effect could be reversed through suppression of the transcription activity of G9a with BIX or siRNA. In addition, the Nrf2/HO-1 pathway, upstream of Nox4, was activated in both BIX-treated mice and G9a-inhibited HUVECs. Collectively, our results demonstrated that inhibition of G9a-alleviated corneal angiogenesis by inhibiting Nox4-dependent ROS production through the Nrf2/HO-1 signaling pathway. These findings indicate that G9a may be a valuable therapeutic target for CoNV.


2016 ◽  
Vol 38 (1) ◽  
pp. 75-82 ◽  
Author(s):  
XUE-JUN GU ◽  
XIAN LIU ◽  
YING-YING CHEN ◽  
YAO ZHAO ◽  
MAN XU ◽  
...  

2021 ◽  
Vol 203 ◽  
pp. 108399
Author(s):  
Jiande Li ◽  
Shaobo Du ◽  
Yongpeng Shi ◽  
Jiangyuan Han ◽  
Zhanyu Niu ◽  
...  

2012 ◽  
Vol 10 (1) ◽  
pp. 307-318 ◽  
Author(s):  
Xinyu Li ◽  
Qinbo Zhou ◽  
Jakub Hanus ◽  
Chastain Anderson ◽  
Hongmei Zhang ◽  
...  

2002 ◽  
Vol 7 (4) ◽  
pp. 8-10
Author(s):  
Christopher R. Brigham ◽  
Leon H. Ensalada

Abstract Recurrent radiculopathy is evaluated by a different approach in the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, compared to that in the Fourth Edition. The AMA Guides, Fifth Edition, specifies several occasions on which the range-of-motion (ROM), not the Diagnosis-related estimates (DRE) method, is used to rate spinal impairments. For example, the AMA Guides, Fifth Edition, clarifies that ROM is used only for radiculopathy caused by a recurrent injury, including when there is new (recurrent) disk herniation or a recurrent injury in the same spinal region. In the AMA Guides, Fourth Edition, radiculopathy was rated using the Injury Model, which is termed the DRE method in the Fifth Edition. Also, in the Fourth Edition, for the lumbar spine all radiculopathies resulted in the same impairment (10% whole person permanent impairment), based on that edition's philosophy that radiculopathy is not quantifiable and, once present, is permanent. A rating of recurrent radiculopathy suggests the presence of a previous impairment rating and may require apportionment, which is the process of allocating causation among two or more factors that caused or significantly contributed to an injury and resulting impairment. A case example shows the divergent results following evaluation using the Injury Model (Fourth Edition) and the ROM Method (Fifth Edition) and concludes that revisions to the latter for rating permanent impairments of the spine often will lead to different results compared to using the Fourth Edition.


1997 ◽  
Vol 2 (4) ◽  
pp. 1-3
Author(s):  
James B. Talmage

Abstract The AMA Guides to the Evaluation of Permanent Impairment, Fourth Edition, uses the Injury Model to rate impairment in people who have experienced back injuries. Injured individuals who have not required surgery can be rated using differentiators. Challenges arise when assessing patients whose injuries have been treated surgically before the patient is rated for impairment. This article discusses five of the most common situations: 1) What is the impairment rating for an individual who has had an injury resulting in sciatica and who has been treated surgically, either with chemonucleolysis or with discectomy? 2) What is the impairment rating for an individual who has a back strain and is operated on without reasonable indications? 3) What is the impairment rating of an individual with sciatica and a foot drop (major anterior tibialis weakness) from L5 root damage? 4) What is the rating for an individual who is injured, has true radiculopathy, undergoes a discectomy, and is rated as Category III but later has another injury and, ultimately, a second disc operation? 5) What is the impairment rating for an older individual who was asymptomatic until a minor strain-type injury but subsequently has neurogenic claudication with severe surgical spinal stenosis on MRI/myelography? [Continued in the September/October 1997 The Guides Newsletter]


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