scholarly journals Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Julian Muwanguzi ◽  
Gisela Henriques ◽  
Patrick Sawa ◽  
Teun Bousema ◽  
Colin J. Sutherland ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Artemisinin Combination Therapy ◽  
Therapy Treatment

scholarly journals Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana

2007 ◽  
Vol 51 (9) ◽  
pp. 3407-3409 ◽  
Author(s):  
Stephan Ehrhardt ◽  
Teunis A. Eggelte ◽  
Sarah Kaiser ◽  
Lydia Adjei ◽  
Gerd D. Burchard ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Life Span ◽  
Large Scale ◽  
Artemisinin Combination Therapy ◽  
Dry Season ◽  
Chloroquine Resistance ◽  
Northern Ghana ◽  
Resistance Marker

ABSTRACT Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

scholarly journals Reduction of multiplicity of infections but no change in msp2 genetic diversity in Plasmodium falciparum isolates from Congolese children after introduction of artemisinin-combination therapy

2012 ◽  
Vol 11 (1) ◽  
pp. 410 ◽  
Author(s):  
Rod Ibara-Okabande ◽  
Felix Koukouikila-Koussounda ◽  
Mathieu Ndounga ◽  
Jeannhey Vouvoungui ◽  
Vladimir Malonga ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Artemisinin Combination Therapy

scholarly journals Decreasingpfmdr1Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is RegainingIn VitroSusceptibility to Mefloquine

2015 ◽  
Vol 59 (5) ◽  
pp. 2934-2937 ◽  
Author(s):  
Pharath Lim ◽  
Dalin Dek ◽  
Vorleak Try ◽  
Sokunthea Sreng ◽  
Seila Suon ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Molecular Marker ◽  
Copy Number ◽  
Artemisinin Combination Therapy ◽  
Clinical Isolates ◽  
Content Type

ABSTRACTDihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) forPlasmodium falciparummalaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS+MQ) as a replacement ACT, we measured the prevalence of multiplepfmdr1copies—a molecular marker for MQ resistance—in 844P. falciparumclinical isolates collected in 2008 to 2013. Thepfmdr1copy number is decreasing in Western Cambodia, suggesting thatP. falciparumis regainingin vitrosusceptibility to MQ.

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