scholarly journals SD Bioline malaria antigen Pf (HRP-2/pLHD) for assessing efficacy of artemisinin combination therapy against Plasmodium falciparum in pedriatric patients in the Democratic Republic of the Congo

2015 ◽  
Vol 22 ◽  
Author(s):  
Albert Lukuka Kilauzi ◽  
Jose Gaby Tshikuka ◽  
Mgaywa Gilbert Mjungu ◽  
Reginald Matchaba-Hove ◽  
Roy Tapera ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Democratic Republic ◽  
Artemisinin Combination Therapy ◽  
Malaria Antigen ◽  
Republic Of The Congo

scholarly journals Adherence to Artemisinin Combination Therapy for the treatment of uncomplicated malaria in the Democratic Republic of the Congo

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 51 ◽  
Author(s):  
M. Ruby Siddiqui ◽  
Andrew Willis ◽  
Karla Bil ◽  
Jatinder Singh ◽  
Eric Mukomena Sompwe ◽  
...  
Keyword(s):  
Side Effects ◽  
Combination Therapy ◽  
Uncomplicated Malaria ◽  
Democratic Republic ◽  
Artemisinin Combination Therapy ◽  
Time Of Day ◽  
Health Conditions ◽  
Blister Pack ◽  
Poor Understanding ◽  
Republic Of The Congo

Between 2011 and 2013 the number of recorded malaria cases had more than doubled, and between 2009 and 2013 had increased almost 4-fold in MSF-OCA (Médecins sans Frontières – Operational Centre Amsterdam) programmes in the Democratic Republic of the Congo (DRC). The reasons for this rise are unclear. Incorrect intake of Artemisinin Combination Therapy (ACT) could result in failure to treat the infection and potential recurrence. An adherence study was carried out to assess whether patients were completing the full course of ACT.One hundred and eight malaria patients in Shamwana, Katanga province, DRC were visited in their households the day after ACT was supposed to be completed. They were asked a series of questions about ACT administration and the blister pack was observed (if available).Sixty seven (62.0%) patients were considered probably adherent. This did not take into account the patients that vomited or spat their pills or took them at the incorrect time of day, in which case adherence dropped to 46 (42.6%). The most common reason that patients gave for incomplete/incorrect intake was that they were vomiting or felt unwell (10 patients (24.4%), although the reasons were not recorded for 22 (53.7%) patients). This indicates that there may be poor understanding of the importance of completing the treatment or that the side effects of ACT were significant enough to over-ride the pharmacy instructions.Adherence to ACT was poor in this setting. Health education messages emphasising the need to complete ACT even if patients vomit doses, feel unwell or their health conditions improve should be promoted.

scholarly journals Adherence to Artemisinin Combination Therapy for the treatment of uncomplicated malaria in the Democratic Republic of the Congo

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 51 ◽  
Author(s):  
M. Ruby Siddiqui ◽  
Andrew Willis ◽  
Karla Bil ◽  
Jatinder Singh ◽  
Eric Mukomena Sompwe ◽  
...  
Keyword(s):  
Side Effects ◽  
Combination Therapy ◽  
Uncomplicated Malaria ◽  
Democratic Republic ◽  
Artemisinin Combination Therapy ◽  
Time Of Day ◽  
Health Conditions ◽  
Blister Pack ◽  
Poor Understanding ◽  
Republic Of The Congo

Between 2011 and 2013 the number of recorded malaria cases had more than doubled, and between 2009 and 2013 had increased almost 4-fold in MSF-OCA (Médecins sans Frontières – Operational Centre Amsterdam) programmes in the Democratic Republic of the Congo (DRC). The reasons for this rise are unclear. Incorrect intake of Artemisinin Combination Therapy (ACT) could result in failure to treat the infection and potential recurrence. An adherence study was carried out to assess whether patients were completing the full course of ACT.One hundred and eight malaria patients in Shamwana, Katanga province, DRC were visited in their households the day after ACT was supposed to be completed. They were asked a series of questions about ACT administration and the blister pack was observed (if available).Sixty seven (62.0%) patients were considered probably adherent. This did not take into account the patients that vomited or spat their pills or took them at the incorrect time of day, in which case adherence dropped to 46 (42.6%). The most common reason that patients gave for incomplete/incorrect intake was that they were vomiting or felt unwell (10 patients (24.4%), although the reasons were not recorded for 22 (53.7%) patients). This indicates that there may be poor understanding of the importance of completing the treatment or that the side effects of ACT were significant enough to over-ride the pharmacy instructions.Adherence to ACT was poor in this setting. Health education messages emphasising the need to complete ACT even if patients vomit doses, feel unwell or their health conditions improve should be promoted.

scholarly journals Identification of main malaria vectors and their insecticide resistance profile in internally displaced and indigenous communities in Eastern Democratic Republic of the Congo (DRC)

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Jeanine A. C. M. Loonen ◽  
Dominic B. Dery ◽  
Bertin Z. Musaka ◽  
Janvier B. Bandibabone ◽  
Teun Bousema ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Insecticide Resistance ◽  
Democratic Republic ◽  
Anopheles Funestus ◽  
Indigenous Communities ◽  
Health Concern ◽  
Malaria Vectors ◽  
Species Determination ◽  
Insecticide Susceptibility ◽  
Republic Of The Congo

Abstract Background Malaria remains a major public health concern in the Democratic Republic of the Congo (DRC) and its control is affected by recurrent conflicts. Médecins Sans Frontières (MSF) initiated several studies to better understand the unprecedented incidence of malaria to effectively target and implement interventions in emergency settings. The current study evaluated the main vector species involved in malaria transmission and their resistance to insecticides, with the aim to propose the most effective tools and strategies for control of local malaria vectors. Methods This study was performed in 52 households in Shamwana (Katanga, 2014), 168 households in Baraka (South Kivu, 2015) and 269 households in Kashuga (North Kivu, 2017). Anopheles vectors were collected and subjected to standardized Word Health Organization (WHO) and Center for Disease Control (CDC) insecticide susceptibility bioassays. Mosquito species determination was done using PCR and Plasmodium falciparum infection in mosquitoes was assessed by ELISA targeting circumsporozoite protein. Results Of 3517 Anopheles spp. mosquitoes collected, Anopheles gambiae sensu lato (s.l.) (29.6%) and Anopheles funestus (69.1%) were the main malaria vectors. Plasmodium falciparum infection rates for An. gambiae s.l. were 1.0, 2.1 and 13.9% for Shamwana, Baraka and Kashuga, respectively. Anopheles funestus showed positivity rates of 1.6% in Shamwana and 4.4% in Baraka. No An. funestus were collected in Kashuga. Insecticide susceptibility tests showed resistance development towards pyrethroids in all locations. Exposure to bendiocarb, malathion and pirimiphos-methyl still resulted in high mosquito mortality. Conclusions This is one of only few studies from these conflict areas in DRC to report insecticide resistance in local malaria vectors. The data suggest that current malaria prevention methods in these populations are only partially effective, and require additional tools and strategies. Importantly, the results triggered MSF to consider the selection of a new insecticide for indoor residual spraying (IRS) and a new long-lasting insecticide-treated net (LLIN). The reinforcement of correct usage of LLINs and the introduction of targeted larviciding were also included as additional vector control tools as a result of the studies.

scholarly journals Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana

2007 ◽  
Vol 51 (9) ◽  
pp. 3407-3409 ◽  
Author(s):  
Stephan Ehrhardt ◽  
Teunis A. Eggelte ◽  
Sarah Kaiser ◽  
Lydia Adjei ◽  
Gerd D. Burchard ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Combination Therapy ◽  
Life Span ◽  
Large Scale ◽  
Artemisinin Combination Therapy ◽  
Dry Season ◽  
Chloroquine Resistance ◽  
Northern Ghana ◽  
Resistance Marker

ABSTRACT Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

Sign in / Sign up

Export Citation Format

Share Document