scholarly journals Several Plasmodium vivax relapses after correct primaquine treatment in a patient with impaired cytochrome P450 2D6 function

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Alexandra Martin Ramírez ◽  
Carlos Lombardia González ◽  
Tamara Soler Maniega ◽  
Ángela Gutierrez Liarte ◽  
Diego Domingo García ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Plasmodium Vivax ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia

2020 ◽  
Vol 114 (9) ◽  
pp. 700-703
Author(s):  
Noor Hafizan Mat Salleh ◽  
Mohd Faizal Abdul Rahman ◽  
Samsiah Samsusah ◽  
Jeremy Ryan De Silva ◽  
David Chun-Ern Ng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cytochrome P450 ◽  
Case Report ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Microsatellite Analysis ◽  
Cytochrome P450 2D6 ◽  
Liver Stage ◽  
Plasmodium Vivax Malaria ◽  
P450 2D6

Abstract Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resistance analysis indicated that Riamet (artemether–lumefantrine) is effective. Cytochrome P450 2D6 (CYP2D6) testing showed that this patient has defective CYP2D6 function. Primaquine failure to clear the Plasmodium vivax hypnozoites may be the cause of recurring infections in this patient. This report highlights the need for the development of liver-stage curative antimalarials that do not require metabolism by the CYP2D6 enzyme.

Probing Small-Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts

ChemMedChem ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. 2088-2101 ◽  
Author(s):  
Gianluca Rossato ◽  
Beat Ernst ◽  
Martin Smiesko ◽  
Morena Spreafico ◽  
Angelo Vedani
Keyword(s):  
Cytochrome P450 ◽  
Small Molecule ◽  
In Silico ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans

2017 ◽  
Vol 14 (3) ◽  
pp. 649-657 ◽  
Author(s):  
Jie Gao ◽  
Xin Tian ◽  
Jun Zhou ◽  
Ming-Zhu Cui ◽  
Hai-Feng Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Clearance ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

2005 ◽  
Vol 15 (10) ◽  
pp. 2647-2652 ◽  
Author(s):  
Bertrand Le Bourdonnec ◽  
Christopher W. Ajello ◽  
Pamela R. Seida ◽  
Roberta G. Susnow ◽  
Joel A. Cassel ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Opioid Receptor ◽  
Inhibitory Activity ◽  
Cytochrome P450 2D6 ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists ◽  
P450 2D6

Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis

2012 ◽  
Vol 20 (6) ◽  
pp. 2042-2053 ◽  
Author(s):  
Svava Ósk Jónsdóttir ◽  
Tine Ringsted ◽  
Nikolai G. Nikolov ◽  
Marianne Dybdahl ◽  
Eva Bay Wedebye ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Qsar Analysis ◽  
P450 2D6
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