scholarly journals Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

2018 ◽  
Vol 1 (4) ◽  
pp. e181449 ◽  
Author(s):  
J. Kevin Baird ◽  
Melva Louisa ◽  
Rintis Noviyanti ◽  
Lenny Ekawati ◽  
Iqbal Elyazar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Therapeutic Efficacy ◽  
Cytochrome P450 2D6 ◽  
Plasmodium Vivax Malaria ◽  
P450 2D6

Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia

2020 ◽  
Vol 114 (9) ◽  
pp. 700-703
Author(s):  
Noor Hafizan Mat Salleh ◽  
Mohd Faizal Abdul Rahman ◽  
Samsiah Samsusah ◽  
Jeremy Ryan De Silva ◽  
David Chun-Ern Ng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cytochrome P450 ◽  
Case Report ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Microsatellite Analysis ◽  
Cytochrome P450 2D6 ◽  
Liver Stage ◽  
Plasmodium Vivax Malaria ◽  
P450 2D6

Abstract Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resistance analysis indicated that Riamet (artemether–lumefantrine) is effective. Cytochrome P450 2D6 (CYP2D6) testing showed that this patient has defective CYP2D6 function. Primaquine failure to clear the Plasmodium vivax hypnozoites may be the cause of recurring infections in this patient. This report highlights the need for the development of liver-stage curative antimalarials that do not require metabolism by the CYP2D6 enzyme.

Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients

2020 ◽  
Author(s):  
Anne Cristine Almeida ◽  
Anna Beatriz Ribeiro Elias ◽  
Maria Paula Marques ◽  
Gisely Cardoso Melo ◽  
Allyson Guimarães Costa ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Antimalarial Treatment ◽  
Cytochrome P450 Activity ◽  
Plasmodium Vivax Malaria ◽  
P450 Activity

scholarly journals Several Plasmodium vivax relapses after correct primaquine treatment in a patient with impaired cytochrome P450 2D6 function

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Alexandra Martin Ramírez ◽  
Carlos Lombardia González ◽  
Tamara Soler Maniega ◽  
Ángela Gutierrez Liarte ◽  
Diego Domingo García ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Plasmodium Vivax ◽  
Cytochrome P450 2D6 ◽  
P450 2D6
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