scholarly journals Epidemiological characteristics of 1385 primary sacral tumors in one institution in China

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Jun Wang ◽  
Dasen Li ◽  
Rongli Yang ◽  
Xiaodong Tang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Clinical Characteristics ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Age Group ◽  
Histologic Type ◽  
Anatomic Site ◽  
Sacral Tumors ◽  
Histologic Types ◽  
Tumor Like Lesions

Abstract Background Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type, and anatomic site in China. Methods A total of 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study. Results A total of 51.7% (716 cases) were malignant and 48.3% (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma, and other histologic types. The most common histological type of benign tumors was a giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma, and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had gender predilection. Chordoma, chondrosarcoma, myeloma, and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma, and epidermoid cyst more frequently affected females than males. Conclusions The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type, and anatomic site in China and features of sacral tumors and tumor-like lesions are fairly distinct from the mobile spine and extremities.

scholarly journals Clinical characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

2020 ◽  
Author(s):  
Jun Wang ◽  
Dasen Li ◽  
Rongli Yang ◽  
Xiaodong Tang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Clinical Characteristics ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Age Group ◽  
Histologic Type ◽  
Anatomic Site ◽  
Sacral Tumors ◽  
Histologic Types ◽  
Tumor Like Lesions

Abstract Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type and anatomic site in China.Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type and anatomic site in China and features of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

scholarly journals Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

2020 ◽  
Author(s):  
Jun Wang ◽  
Dasen Li ◽  
Rongli Yang ◽  
Xiaodong Tang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Nerve Sheath Tumor ◽  
Age Group ◽  
Sacral Tumors ◽  
Histologic Types ◽  
Tumor Like Lesions ◽  
Epidemiological Characteristics

Abstract Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about the epidemiological characteristics of them in China. Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study. Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males. Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their epidemiologic characteristics in China and epidemiological feature of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

scholarly journals Epidemiological characteristics of 1385 primary sacral tumors in one institution in China

2020 ◽  
Author(s):  
Jun Wang ◽  
Dasen Li ◽  
Rongli Yang ◽  
Xiaodong Tang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Nerve Sheath Tumor ◽  
Age Group ◽  
Mobile Spine ◽  
Sacral Tumors ◽  
Histologic Types ◽  
Epidemiological Characteristics

Abstract Background: Primary sacral tumors (PST) are a rare group of skeletal tumors that can affect children and adults of all ages. Little is known about the epidemiological characteristics of PST in China.Methods: 1385 patients with primary sacral tumors, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma of PST affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of primary sacral tumors in our database may reveal their epidemiologic characteristics of primary sacral malignant and benign tumors in China and epidemiological feature of PST is fairly distinct from the mobile spine and extremities.

scholarly journals STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Shuxin Chen ◽  
Zepeng Du ◽  
Bingli Wu ◽  
Huiyang Shen ◽  
Chunpeng Liu ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Characteristics ◽  
Multivariate Logistic Regression Analysis ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Small Gtpase ◽  
Cell Tumor ◽  
Functional Enrichment ◽  
Ppi Network

Background. In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence. Methods. The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis. Results. It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P<0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response. Conclusion. MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.

The Clinical Characteristics of Giant Cell Tumor of Bone with Aneurysmal Bone Cyst

2016 ◽  
Vol 51 (5) ◽  
pp. 411
Author(s):  
Hyung Min Lee ◽  
Se Kyung Park ◽  
En Mi Cho ◽  
Sun Ju Oh ◽  
So Hak Chung
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Aneurysmal Bone Cyst ◽  
Clinical Characteristics ◽  
Bone Cyst ◽  
Cell Tumor

scholarly journals Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

2017 ◽  
Vol 7 ◽  
pp. 23-28 ◽  
Author(s):  
Yongkun Yang ◽  
Zhen Huang ◽  
Xiaohui Niu ◽  
Hairong Xu ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Clinical Characteristics ◽  
Cell Tumor ◽  
Factors Analysis

Evaluation of factors associated with postoperative infection following sacral tumor resection

2008 ◽  
Vol 9 (6) ◽  
pp. 593-599 ◽  
Author(s):  
Daniel M. Sciubba ◽  
Clarke Nelson ◽  
Beryl Gok ◽  
Matthew J. McGirt ◽  
Gregory S. McLoughlin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Bladder Dysfunction ◽  
Cell Tumor ◽  
Wound Complications ◽  
Factors Associated ◽  
Sacral Tumor ◽  
Bowel And Bladder Dysfunction ◽  
Tissue Reconstruction ◽  
Sacral Tumors

Object Resection of sacral tumors has been shown to improve survival, since the oncological prognosis is commonly correlated with the extent of local tumor control. However, extensive soft-tissue resection in close proximity to the rectum may predispose patients to wound complications and infection. To identify potential risk factors, a review of clinical outcomes for sacral tumor resections over the past 5 years at a single institution was completed, paying special attention to procedure-related complications. Methods Between 2002 and 2007, 46 patients with sacral tumors were treated with surgery. Demographic data, details of surgery, type of tumor, and patient characteristics associated with surgical site infections (SSIs) were collected; these data included presence of the following variables: diabetes, obesity, smoking, steroid use, previous surgery, previous radiation, cerebrospinal fluid leak, number of spinal levels exposed, instrumentation, number of surgeons scrubbed in to the procedure, serum albumin level, and combined anterior-posterior approach. Logistic regression analysis was implemented to find an association of such variables with the presence of SSI. Results A total of 46 patients were treated for sacral tumor resections; 20 were male (43%) and 26 were female (57%), with an average age of 46 years (range 11–83 years). Histopathological findings included the following: chordoma in 19 (41%), ependymoma in 5 (11%), rectal adenocarcinoma in 5 (11%), giant cell tumor in 4 (9%), and other in 13 (28%). There were 18 cases of wound infection (39%), and 2 cases of repeat surgery for tumor recurrence (1 chordoma and 1 giant cell tumor). Factors associated with increased likelihood of infection included previous lumbosacral surgery (p = 0.0184; odds ratio [OR] 7.955) and number of surgeons scrubbed in to the operation (p = 0.0332; OR 4.018). Increasing age (p = 0.0864; OR 1.031), presence of complex soft-tissue reconstruction (p = 0.118; OR 3.789), and bowel and bladder dysfunction (p = 0.119; OR 2.667) demonstrated a trend toward increased risk of SSI. Conclusions Patients undergoing sacral tumor surgery may be at greater risk for developing wound complications due to the extensive soft-tissue resections often required, especially with the increased potential for contamination from the neighboring rectum. In this study, it appears that previous lumbosacral surgery, number of surgeons scrubbed in, patient age, bowel and bladder dysfunction, and complex tissue reconstruction may predict those patients more prone to developing postoperative SSIs.

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