Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Abstract Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about the epidemiological characteristics of them in China. Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study. Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males. Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their epidemiologic characteristics in China and epidemiological feature of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

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Epidemiological characteristics of 1385 primary sacral tumors in one institution in China

10.21203/rs.3.rs-28800/v1 ◽

2020 ◽

Author(s):

Jun Wang ◽

Dasen Li ◽

Rongli Yang ◽

Xiaodong Tang ◽

Taiqiang Yan ◽

...

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Cell Tumor ◽

Benign Tumors ◽

Nerve Sheath Tumor ◽

Age Group ◽

Mobile Spine ◽

Sacral Tumors ◽

Histologic Types ◽

Epidemiological Characteristics

Abstract Background: Primary sacral tumors (PST) are a rare group of skeletal tumors that can affect children and adults of all ages. Little is known about the epidemiological characteristics of PST in China.Methods: 1385 patients with primary sacral tumors, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma of PST affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of primary sacral tumors in our database may reveal their epidemiologic characteristics of primary sacral malignant and benign tumors in China and epidemiological feature of PST is fairly distinct from the mobile spine and extremities.

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Epidemiological characteristics of 1385 primary sacral tumors in one institution in China

World Journal of Surgical Oncology ◽

10.1186/s12957-020-02045-w ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Jun Wang ◽

Dasen Li ◽

Rongli Yang ◽

Xiaodong Tang ◽

Taiqiang Yan ◽

...

Keyword(s):

Giant Cell Tumor ◽

Clinical Characteristics ◽

Cell Tumor ◽

Benign Tumors ◽

Age Group ◽

Histologic Type ◽

Anatomic Site ◽

Sacral Tumors ◽

Histologic Types ◽

Tumor Like Lesions

Abstract Background Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type, and anatomic site in China. Methods A total of 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study. Results A total of 51.7% (716 cases) were malignant and 48.3% (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma, and other histologic types. The most common histological type of benign tumors was a giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma, and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had gender predilection. Chordoma, chondrosarcoma, myeloma, and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma, and epidermoid cyst more frequently affected females than males. Conclusions The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type, and anatomic site in China and features of sacral tumors and tumor-like lesions are fairly distinct from the mobile spine and extremities.

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Clinical characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

10.21203/rs.3.rs-28800/v3 ◽

2020 ◽

Author(s):

Jun Wang ◽

Dasen Li ◽

Rongli Yang ◽

Xiaodong Tang ◽

Taiqiang Yan ◽

...

Keyword(s):

Giant Cell Tumor ◽

Clinical Characteristics ◽

Cell Tumor ◽

Benign Tumors ◽

Age Group ◽

Histologic Type ◽

Anatomic Site ◽

Sacral Tumors ◽

Histologic Types ◽

Tumor Like Lesions

Abstract Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type and anatomic site in China.Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type and anatomic site in China and features of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

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Goltz Syndrome with Multiple Giant-Cell Tumor-Like Lesions in Bones

Annals of Internal Medicine ◽

10.7326/0003-4819-80-6-714 ◽

1974 ◽

Vol 80 (6) ◽

pp. 714 ◽

Cited By ~ 16

Author(s):

GOLDA SELZER

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Cell Tumor ◽

Goltz Syndrome ◽

Tumor Like Lesions

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Giant cell tumor of patella: A case report and review of literature

Journal of Emergency Practice and Trauma ◽

10.15171/jept.2019.06 ◽

2019 ◽

Vol 6 (1) ◽

pp. 47-49

Author(s):

Mohit Kumar Arora ◽

Ela Madaan ◽

Rajnand Kumar

Keyword(s):

Case Report ◽

Giant Cell Tumor ◽

Giant Cell ◽

Knee Pain ◽

Anterior Knee Pain ◽

Cell Tumor ◽

Extensor Mechanism ◽

Benign Tumors ◽

Primary Tumors ◽

Anterior Knee

Objective: Patella is a sesamoid bone which develops in the quadriceps tendon. It is an uncommon site for neoplasms. The most common primary tumors which involve patella are benign. These include chondroblastoma, giant cell tumor (GCT) and aneurysmal bone cyst. Malignant lesions are less common in patella. These encompass metastasis, osteosarcoma and hemangioendothelioma. The most common complaint in patients of GCT patella is anterior knee pain. Early diagnosis and optimal management are necessary for improving survival rate in these patients. Case Presentation: The authors present a case report of GCT of patella in a 16-year old child. Incisional biopsy was done to confirm the diagnosis. Further radiological examination showed that the tumor involved almost whole of the patella. Hence, surgical management in the form of patellectomy and extensor mechanism repair was done to improve the outcome of the disease. The patient did not have any clinical or radiological symptoms at the end of the final follow up of 22 months. Conclusion: Primary tumor of patella is a rare entity. Benign tumors like GCT present only with anterior knee pain and should be included in the differential diagnosis of anterior knee pain. MRI is useful to determine the extent of involvement of tumor in the patella. Treatment may vary from curettage and bone grafting to total patellectomy with extensor mechanism repair

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Differential Diagnosis of Benign Tumors of Bone Rich in Giant Cells, Based on Immunohistochemistry

Romanian Journal of Orthopaedic Surgery and Traumatology ◽

10.2478/rojost-2018-0060 ◽

2018 ◽

Vol 1 (Supplement) ◽

pp. 49

Author(s):

L. Ali ◽

D.M. Pop ◽

C.I. Stoica

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Polyclonal Antibodies ◽

Bone Cyst ◽

Surgical Excision ◽

Giant Cells ◽

Cell Tumor ◽

Benign Tumors ◽

Ki 67 ◽

S 100

Abstract Introduction. The aim of this study was to investigate several cases of giant cell tumor of bone (TCG), chondroblastoma and aneurysmal bone cyst (ABC) by immunohistochemistry (IHC) with a panel of markers: p63, S-100, CD68, CD56, DOG1, Galectin-1, D2-40, CD34, CD45 and ki-67, some of which proved to be specific for a certain entity. Material and methods. The cases were retrospectively selected from cases processed in our facility where the surgical excision material was histopathologically analyzed in optical microscopy using the usual staining hematoxylin and eosin. The immunohistochemistry exam was performed at INCDVB by indirect method avidin-biotin-peroxidase complex (C-DAB) with polyclonal antibodies (Dako) for S100; CD56, p63, DOG1, CD34, D2-40, CD45, ki67, and Galectin1 were performed in 14 cases out of which 10 were TGC, 3 chondroblastomas, and one primary ABC. Results. Five out of ten TGC investigated showed p63 diff use nuclear expression in the mononuclear cell. None of the 3 cases of chondroblastoma or ABC-primary or secondary (associated with the above mentioned tumors), expressed p63. Other variables, non-specifically encountered in all of the tumors, were emphasized by CD34 (vascular network), ki-67 (index of proliferation), CD45 (inflammatory infi ltrate). DOG1 expression was found positive in all chondroblastoma cases. Conclusions. p63 proved to be a useful biomarker in differentiating giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, especially chondroblastoma and ABC. Chondroblastoma was particularly rewarding in this investigation by demonstrating the dual immunohistochemical phenotype of the neoplastic cells, both chondroblastic (S-100, D2-40) and osteoblastic (CD56 and Galectin -1). DOG1, which is mainly used for the diagnostic of GIST, was found by many to be also specific, in the proper morphopathological context, for chondroblastoma.

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Tenosynovial Giant Cell Tumor of the Retropharynx: A Case Report With Literature Review

Ear Nose & Throat Journal ◽

10.1177/0145561320966069 ◽

2020 ◽

pp. 014556132096606

Author(s):

Guo Liu ◽

Feng Liu

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Neck Region ◽

Posterior Pharyngeal Wall ◽

Tendon Sheath ◽

Cell Tumor ◽

Benign Tumors ◽

Pharyngeal Wall ◽

Tenosynovial Giant Cell Tumor ◽

Submucosal Mass

Tenosynovial giant cell tumor (TSGCT) represents a family of benign tumors that arise from the synovial tissue of a joint, tendon sheath, or bursa. It usually involves the joints of the extremities and rarely occurs in the head and neck region. Here, we describe a case of a 32-year-old man with a submucosal mass bulging in the posterior pharyngeal wall since one month. The lesion was removed and diagnosed with localized type of TSGCT based on histopathological investigations and clinical presentation. It is very rare that TSGCT occurs in the retropharynx, which reminds clinicians to consider this entity as a possible diagnosis.

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