scholarly journals The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation

2014 ◽  
Vol 12 (1) ◽  
Author(s):  
Naima Zemirli ◽  
Marie Pourcelot ◽  
Neslihan Dogan ◽  
Aimé Vazquez ◽  
Damien Arnoult
Keyword(s):  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Positive Regulator

scholarly journals The E3 ubiquitin ligase RNF121 is a positive regulator of NF-¿B activation

2014 ◽  
Vol 12 (1) ◽  
pp. 72
Author(s):  
Naima Zemirli ◽  
Marie Pourcelot ◽  
Neslihan Dogan ◽  
Aimé Vazquez ◽  
Damien Arnoult
Keyword(s):  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Positive Regulator

scholarly journals E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

2021 ◽  
Author(s):  
Yuhua Shi ◽  
Yang Yang ◽  
Weilv Xu ◽  
Wei Xu ◽  
Xinyu Fu ◽  
...  
Keyword(s):  
Cell Death ◽  
Ubiquitin Ligase ◽  
Essential Role ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
E3 Ubiquitin Ligase ◽  
Positive Regulator ◽  
Ldh Release

Gasdermin D (GSDMD) participates in activation of inflammasomes and pyroptosis. Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how ubiquitination regulates Gasdermin D activity is not well understood. In this study, we show that pyroptosis triggered by Gasdermin D is regulated through ubiquitination. Specifically, SYVN1, an E3 ubiquitin ligase of gasdermin D, promotes GSDMD-mediated pyroptosis. SYVN1 deficiency inhibits pyroptosis and subsequent LDH release and PI uptake. SYVN1 directly interacts with GSDMD, and mediates K27-linked polyubiquitination of GSDMD on K203 and K204 residues, promoting GSDMD-induced pyroptotic cell death. Thus, our findings revealed the essential role of SYVN1 in GSDMD-mediated pyroptosis. Overall, GSDMD ubiquitination is a potential therapeutic module for inflammatory diseases.

scholarly journals The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis

2013 ◽  
Vol 25 (2) ◽  
pp. 728-743 ◽  
Author(s):  
Verónica G. Doblas ◽  
Vítor Amorim-Silva ◽  
David Posé ◽  
Abel Rosado ◽  
Alicia Esteban ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Coenzyme A ◽  
Reductase Activity ◽  
E3 Ubiquitin Ligase ◽  
Positive Regulator ◽  
Coenzyme A Reductase

Author response for "TAM receptors attenuate murine NK cell responses via E3 ubiquitin ligase Cbl‐b"

2019 ◽  
Author(s):  
Leilani M. Chirino ◽  
Suresh Kumar ◽  
Mariko Okumura ◽  
David E. Sterner ◽  
Michael Mattern ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Nk Cell ◽  
E3 Ubiquitin Ligase ◽  
Author Response ◽  
Cell Responses ◽  
Tam Receptors
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