scholarly journals Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Stephanie Yacoub ◽  
Kenneth Cadesky ◽  
Robert F. Casper
Keyword(s):  
Ovarian Stimulation ◽  
Polycystic Ovary ◽  
Case Series ◽  
Low Risk ◽  
Retrospective Case ◽  
Vitro Fertilization ◽  
Retrospective Case Series ◽  
Dosing Algorithm ◽  
Individualized Dosing

Abstract Background To explore the efficacy of follitropin delta in ovarian stimulation of patients with the Rotterdam ESHRE/ASRM 2003 phenotypes of polycystic ovarian syndrome (PCOS) using a retrospective case series with an electronic file search in a reproductive medicine clinic. Case presentation Seventy-four patients with PCOS undergoing ovarian stimulation according to the individualized dosing algorithm of follitropin delta for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)/oocyte freezing were included. Follitropin delta resulted in a high number of pre-ovulatory follicles at the end of stimulation as expected in patients with PCOS. There was a large number of oocytes retrieved with an acceptable percentage of metaphase II (MII) oocytes. There were no cases of moderate or severe OHSS across all phenotypes. Conclusion Follitropin delta, using the individualized dosing algorithm, appears to be a safe method of ovarian stimulation with a low risk of OHSS in PCOS patients without sacrificing successful stimulation outcomes.

Time-lapse monitoring of zona pellucida-free embryos obtained through in vitro fertilization: a retrospective case series

2015 ◽  
Vol 103 (5) ◽  
pp. e35 ◽  
Author(s):  
Daniel Bodri ◽  
Ryutaro Kato ◽  
Masae Kondo ◽  
Naoko Hosomi ◽  
Yoshinari Katsumata ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Zona Pellucida ◽  
Case Series ◽  
Time Lapse ◽  
Retrospective Case ◽  
Vitro Fertilization ◽  
Retrospective Case Series

scholarly journals The Place of In Vitro Maturation in Assisted Reproductive Technology

2019 ◽  
Vol 01 (01) ◽  
pp. 11-15 ◽  
Author(s):  
Lan N. Vuong ◽  
Tuong M. Ho ◽  
Robert B. Gilchrist ◽  
Johan Smitz
Keyword(s):  
Assisted Reproductive Technology ◽  
Ovarian Stimulation ◽  
In Vitro Maturation ◽  
Polycystic Ovary ◽  
Reproductive Technology ◽  
Vitro Fertilization ◽  
Medication Costs ◽  
Main Barrier ◽  
Patient Burden

In vitro maturation (IVM) is an assisted reproductive technology (ART) whereby immature cumulus-oocyte complexes are collected and matured in vitro, without need for controlled ovarian stimulation and ovulation triggering. Advantages of IVM over in vitro fertilization (IVF) include mild or no stimulation, lower medication costs and less patient burden. However, early clinical outcomes with IVM were suboptimal. More recently, clinical studies reported live birth rates after IVM of about 40%. New IVM culture systems are being used to improve the efficacy of IVM. These have been in widespread use for animals for many years and are now showing promise in the clinical setting. Patients more likely to benefit from IVM over IVF include those at risk of OHSS (e.g. women with polycystic ovary syndrome), when the time for ovarian stimulation is limited, or where sustained elevations of estradiol are contraindicated (e.g. oncofertility indications). The main barrier to use of IVM to date was its relative efficacy compared with IVF, and there have also been concerns over the health of infants born following IVM. However, no differences in congenital abnormalities between IVM and other ARTs have been identified. In addition, there is a lack of both experience and standardized protocols. Strategies to overcome barriers to the use of IVM include better training for clinicians, more and better funded research in the field, and improved recognition of IVM by fertility specialists. Overall, IVM offers a valuable alternative for ART in select patient populations. New approaches to IVM appear to have the potential to achieve pregnancy outcomes equivalent to those after IVF. Increasing the use of IVM in the future can be achieved with improved training and education for fertility specialists, and increased funding for IVM research, with the ultimate goal of improving fertility outcomes.

scholarly journals Inositol Treatment and ART Outcomes in Women with PCOS

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Deepika Garg ◽  
Reshef Tal
Keyword(s):  
Ovarian Stimulation ◽  
Ovarian Function ◽  
Current Knowledge ◽  
Polycystic Ovary ◽  
Mature Oocyte ◽  
Reproductive Age ◽  
Vitro Fertilization ◽  
Ovulatory Dysfunction ◽  
Ovarian Morphology

Polycystic ovary syndrome (PCOS) affects 5–10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology is still unknown but is believed to be multifactorial. Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Administration of inositol in PCOS has been shown to improve not only the metabolic and hormonal parameters but also ovarian function and the response to assisted-reproductive technology (ART). Accumulating evidence suggests that it is also capable of improving folliculogenesis and embryo quality and increasing the mature oocyte yield following ovarian stimulation for ART in women with PCOS. In the current review, we collate the evidence and summarize our current knowledge on ovarian stimulation and ART outcomes following inositol treatment in women with PCOS undergoing in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI).

Duration of ovarian stimulation is predictive of in-vitro fertilization outcomes

2020 ◽  
Vol 71 (6) ◽  
Author(s):  
Papri Sarkar ◽  
Luke Ying ◽  
Shayne Plosker ◽  
James Mayer ◽  
Ying Ying ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Stimulation ◽  
Vitro Fertilization
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