When is enough enough? Pregnancy rate and cost-effectiveness of three cycles homologous intrauterine insemination (IUI) vs. one cycle mild ovarian stimulation in vitro fertilization (IVF)

2016 ◽  
Author(s):  
Aboubakar Cissé
Keyword(s):  
Cost Effectiveness ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Ovarian Stimulation ◽  
Intrauterine Insemination ◽  
Vitro Fertilization ◽  
Mild Ovarian Stimulation

scholarly journals Human Recombinant FSH and Its Biosimilars: Clinical Efficacy, Safety, and Cost-Effectiveness in Controlled Ovarian Stimulation for In Vitro Fertilization

2020 ◽  
Vol 13 (7) ◽  
pp. 136
Author(s):  
Loredana Bergandi ◽  
Stefano Canosa ◽  
Andrea Roberto Carosso ◽  
Carlotta Paschero ◽  
Gianluca Gennarelli ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
In Vitro Fertilization ◽  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation ◽  
Vitro Fertilization ◽  
Follitropin Alfa ◽  
Extraction And Purification ◽  
Recombinant Technology ◽  
Stimulation Of

Exogenous human follicle-stimulating hormone (hFSH), either derived from extraction and purification from the urine or obtained by recombinant technology in the form of follitropin α, β and δ (rFSH), has been used for decades in the treatment of infertility. The main applications of FSH treatment in the woman have been, and still are, ovulation induction in oligo-anovulatory subjects, and stimulation of the development of a cohort of follicles in patients undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF). In the last years, two biosimilars of follitropin alfa, rFSH compounds structurally and functionally similar to the originator, have been approved and marketed for clinical use in Europe. Moreover, some other rFSH biosimilars are currently under investigation. The objective of this article is to review the available evidences comparing the efficacy, safety, and cost-effectiveness of rFSH follitropin alpha originator with its biosimilars, discussing the clinical trials that allowed biosimilars to get registration and marketing authorization.

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