scholarly journals Resuscitation speed affects brain injury in a large animal model of traumatic brain injury and shock

2014 ◽  
Vol 22 (1) ◽  
Author(s):  
Martin Sillesen ◽  
Guang Jin ◽  
Pär I Johansson ◽  
Hasan B Alam
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Large Animal Model ◽  
Large Animal

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

2013 ◽  
Vol 74 (5) ◽  
pp. 1252-1259 ◽  
Author(s):  
Martin Sillesen ◽  
Pär I. Johansson ◽  
Lars S. Rasmussen ◽  
Guang Jin ◽  
Cecilie H. Jepsen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Platelet Activation ◽  
Large Animal Model ◽  
Large Animal

Survival Rates and Biomarkers in A Large Animal Model of Traumatic Brain Injury Combined with Two Different Levels of Blood Loss

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Andrew R. Mayer ◽  
Andrew B. Dodd ◽  
Josef M. Ling ◽  
David D. Stephenson ◽  
Julie G. Rannou-Latella ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Blood Loss ◽  
Survival Rates ◽  
Large Animal Model ◽  
Large Animal ◽  
Different Levels

scholarly journals Periventricular White Matter Alterations From Explosive Blast in a Large Animal Model: Mild Traumatic Brain Injury or “Subconcussive” Injury?

2020 ◽  
Vol 79 (6) ◽  
pp. 605-617
Author(s):  
Jung H Kim ◽  
James A Goodrich ◽  
Robert Situ ◽  
Amedeo Rapuano ◽  
Hoby Hetherington ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
Axonal Injury ◽  
Large Animal Model ◽  
Periventricular White Matter ◽  
Large Animal ◽  
Subconcussive Injury

Abstract The neuropathology of mild traumatic brain injury in humans resulting from exposure to explosive blast is poorly understood as this condition is rarely fatal. A large animal model may better reflect the injury patterns in humans. We investigated the effect of explosive blasts on the constrained head minimizing the effects of whole head motion. Anesthetized Yucatan minipigs, with body and head restrained, were placed in a 3-walled test structure and exposed to 1, 2, or 3 explosive blast shock waves of the same intensity. Axonal injury was studied 3 weeks to 8 months postblast using β-amyloid precursor protein immunohistochemistry. Injury was confined to the periventricular white matter as early as 3–5 weeks after exposure to a single blast. The pattern was also present at 8 months postblast. Animals exposed to 2 and 3 blasts had more axonal injury than those exposed to a single blast. Although such increases in axonal injury may relate to the longer postblast survival time, it may also be due to the increased number of blast exposures. It is possible that the injury observed is due to a condition akin to mild traumatic brain injury or subconcussive injury in humans, and that periventricular injury may have neuropsychiatric implications.

Sign in / Sign up

Export Citation Format

Share Document