scholarly journals ICan, an Internet-based intervention to reduce cannabis use: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Marleen I. A. Olthof ◽  
Matthijs Blankers ◽  
Margriet W. van Laar ◽  
Anna E. Goudriaan
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Brief Intervention ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Substance Use Treatment ◽  
Professional Help ◽  
Web Based ◽  
Randomized Controlled ◽  
Internet Based Intervention

Abstract Background Heavy cannabis use is associated with adverse physical and mental health effects. Despite available effective treatments, the majority of heavy cannabis users does not seek professional help. Web-based interventions can provide an alternative for cannabis users who are reluctant to seek professional help. Several web-based cannabis interventions are effective in reducing cannabis use; however, the effect sizes are typically small and attrition rates are typically high. This suggests that web-based programs can be an effective cannabis use intervention for some, while others may need additional substance use treatment after completing a web-based intervention. Therefore, it is important that web-based interventions do not solely focus on reducing cannabis use, but also on improving attitudes towards substance use treatment. The Screening Brief Intervention and Referral to Treatment (SBIRT) approach appears to be well suited for the purpose of reducing cannabis use and improving substance use treatment utilization. Based on the SBIRT approach—and based on cognitive behavioral therapy (CBT) and motivational interviewing (MI)—we developed the Internet-based cannabis reduction intervention ICan. Methods/design This protocol paper presents the design of a randomized controlled trial (RCT) in which we evaluate the effectiveness of the ICan intervention compared to four online modules of educational information on cannabis in a sample of Dutch frequent cannabis users. The primary outcome measure is frequency of cannabis use. Secondary outcome measures include the quantity of cannabis used (grams), the attitudes towards seeking help and the number of participants who enter specialized treatment services for cannabis use-related problems. Discussion To the best of our knowledge, ICan is the first Internet-based intervention for cannabis users that combines screening, a brief intervention—based on CBT and MI—and referral to treatment options. Trial registration The study is registered in the Netherlands Trial Register; identifier NL7668. Registered on 17 April 2019.

scholarly journals A Web-Based Program for Cannabis Use and Psychotic Experiences in Young People (Keep It Real): Protocol for a Randomized Controlled Trial

10.2196/15803 ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. e15803
Author(s):  
Leanne Hides ◽  
Amanda Baker ◽  
Melissa Norberg ◽  
Jan Copeland ◽  
Catherine Quinn ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Cost Effectiveness ◽  
Young People ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Psychotic Experiences ◽  
Web Based ◽  
Randomized Controlled ◽  
The Past

Background Young Australians (16-25 years) have the highest rates of past-month cannabis use in the world. Cannabis use increases the risk of alcohol and other drug disorders and depressive disorders, and has a robust dose-response association with psychotic experiences (PEs) and disorders. PEs are subthreshold positive psychotic symptoms, including delusions and hallucinations, which increase the risk of substance use, depressive or anxiety disorders, and psychotic disorders. Access to effective web-based early interventions targeting both cannabis use and PEs could reduce such risk in young people. Objective The objective of this study is to determine the efficacy and cost-effectiveness of the Keep it Real web-based program compared to an information-only control website among young cannabis users (16-25 years) with PEs. Methods Participants are recruited online, and consenting individuals meeting inclusion criteria (aged 16-25 years, who have used cannabis in the past month and experienced PEs in the past 3 months) are automatically randomized to either the Keep it Real web-based program (n=249) or an information-only control website (n=249). Both websites are self-guided (fully automated). The baseline and follow-up assessments at 3, 6, 9, and 12 months are self-completed online. Primary outcome measures are weekly cannabis use, PEs, and the relative cost-effectiveness for quality-adjusted life years. Secondary outcomes include other substance use and related problems, PE-related distress, cannabis intoxication experiences, severity of cannabis dependence, depression/anxiety symptoms, suicidality, and mental well-being and functioning. Results Recruitment commenced in February 2019, and the results are expected to be submitted for publication in mid-2021. Conclusions This study protocol describes a large randomized controlled trial of a new web-based program for young cannabis users experiencing PEs. If effective, the accessibility and scalability of Keep it Real could help reduce growing public health concerns about the significant social, economic, and health impacts of cannabis use. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12618001107213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374800 International Registered Report Identifier (IRRID) DERR1-10.2196/15803

scholarly journals A Web-Based Program for Cannabis Use and Psychotic Experiences in Young People (Keep It Real): Protocol for a Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Leanne Hides ◽  
Amanda Baker ◽  
Melissa Norberg ◽  
Jan Copeland ◽  
Catherine Quinn ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Cost Effectiveness ◽  
Young People ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Psychotic Experiences ◽  
Web Based ◽  
Randomized Controlled ◽  
The Past

BACKGROUND Young Australians (16-25 years) have the highest rates of past-month cannabis use in the world. Cannabis use increases the risk of alcohol and other drug disorders and depressive disorders, and has a robust dose-response association with psychotic experiences (PEs) and disorders. PEs are subthreshold positive psychotic symptoms, including delusions and hallucinations, which increase the risk of substance use, depressive or anxiety disorders, and psychotic disorders. Access to effective web-based early interventions targeting both cannabis use and PEs could reduce such risk in young people. OBJECTIVE The objective of this study is to determine the efficacy and cost-effectiveness of the <i>Keep it Real</i> web-based program compared to an information-only control website among young cannabis users (16-25 years) with PEs. METHODS Participants are recruited online, and consenting individuals meeting inclusion criteria (aged 16-25 years, who have used cannabis in the past month and experienced PEs in the past 3 months) are automatically randomized to either the <i>Keep it Real</i> web-based program (n=249) or an information-only control website (n=249). Both websites are self-guided (fully automated). The baseline and follow-up assessments at 3, 6, 9, and 12 months are self-completed online. Primary outcome measures are weekly cannabis use, PEs, and the relative cost-effectiveness for quality-adjusted life years. Secondary outcomes include other substance use and related problems, PE-related distress, cannabis intoxication experiences, severity of cannabis dependence, depression/anxiety symptoms, suicidality, and mental well-being and functioning. RESULTS Recruitment commenced in February 2019, and the results are expected to be submitted for publication in mid-2021. CONCLUSIONS This study protocol describes a large randomized controlled trial of a new web-based program for young cannabis users experiencing PEs. If effective, the accessibility and scalability of <i>Keep it Real</i> could help reduce growing public health concerns about the significant social, economic, and health impacts of cannabis use. CLINICALTRIAL Australian New Zealand Clinical Trials Registry ACTRN12618001107213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374800 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/15803

scholarly journals Web-based screening and brief intervention for hazardous drinking: a double-blind randomized controlled trial

Addiction ◽  
2004 ◽  
Vol 99 (11) ◽  
pp. 1410-1417 ◽  
Author(s):  
Kypros Kypri ◽  
John B. Saunders ◽  
Sheila M. Williams ◽  
Rob O. McGee ◽  
John D. Langley ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Brief Intervention ◽  
Controlled Trial ◽  
Hazardous Drinking ◽  
Screening And Brief Intervention ◽  
Double Blind ◽  
Web Based ◽  
Randomized Controlled

scholarly journals Guided web-based treatment program for reducing cannabis use: a randomized controlled trial

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Kristina Sinadinovic ◽  
Magnus Johansson ◽  
Ann-Sofie Johansson ◽  
Thomas Lundqvist ◽  
Philip Lindner ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Program ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Control Group ◽  
Web Based ◽  
Randomized Controlled ◽  
Intervention Adherence ◽  
Group Effects

Abstract Background The aim of this study was to investigate the effects of a web-based treatment program with therapist guidance for adults and adolescents with regular cannabis use from the general population. Methods A double blinded randomized controlled trial with a parallel group design was conducted (intervention group n = 151, wait-list control group n = 152). Follow-up 12 weeks from treatment commencement of a 13-module intervention. The primary outcome was frequency of cannabis use. Time by group interaction effects were modeled using generalized estimated equations and the instrumental variable approach was used to estimate the effect of intervention adherence. Results At follow-up, the intention to treat (ITT) analyses did not show any significant time by group effects. A significant association between intervention adherence and scores on the cannabis abuse screening test (CAST) was found. Secondary analysis excluding participants who had received other professional help revealed time by group effects for secondary outcomes gram cannabis consumed past week, number of dependency criteria and CAST score. Due to methodological limitations, these latter results should be interpreted with caution. Conclusions In this study we did not find a web-based treatment program with therapist guidance to be more effective than a waiting-list in reducing frequency of cannabis use. Trial registration The trial was pre-registered at ClinicalTrials.gov (NCT02408640) April 3, 2015

The Efficacy of a Web-Based Screening and Brief Intervention for Reducing Alcohol Consumption Among Japanese Problem Drinkers: Protocol for a Single-Blind Randomized Controlled Trial (Preprint)

2018 ◽  
Author(s):  
Toshitaka Hamamura ◽  
Shinichiro Suganuma ◽  
Ayumi Takano ◽  
Toshihiko Matsumoto ◽  
Haruhiko Shimoyama
Keyword(s):  
Randomized Controlled Trial ◽  
Brief Intervention ◽  
Alcohol Use Disorder ◽  
Controlled Trial ◽  
Normative Feedback ◽  
Problem Drinkers ◽  
Web Based ◽  
Randomized Controlled ◽  
Main Effects ◽  
Single Blind

BACKGROUND The literature shows that computer-delivered interventions with personalized normative feedback can reduce problem drinking for up to 6 months in the West. Meanwhile, no studies have been conducted to examine the effects of such interventions among Japanese problem drinkers. Possible moderators associated with effectiveness of the intervention need to be also explored. OBJECTIVE The purpose of this study is to conduct a trial and examine the efficacy of a brief intervention with personal normative feedback and psychoeducation on several measures of alcohol consumption among Japanese problem drinkers. Additionally, this study will examine whether the level of alcohol use disorder and beliefs about the physical and psychological outcomes of drinking moderate the effect of the intervention on outcome measures. METHODS This study will conduct a single-blind, 2-armed randomized controlled trial. Japanese adults with an Alcohol Use Disorder Identification Test score of 8 or higher will be enrolled in the trial. Participants allocated to the intervention group will receive the intervention immediately after the baseline measurements, and participants allocated to the waitlist group will receive the intervention at the end of the trial. Outcome measures include drinking quantity, drinking frequency, and alcohol-related consequences. Follow-up assessment will take place at 1 month, 2 months, and 6 months following the baseline measurement. The authors will not know the group allocation during trial. The authors will plan to collect a sample of 600 participants. Mixed-effect analyses of variance will be used to examine the main effects of condition, the main effects of time, and the interaction effects between condition and time on outcome variables. RESULTS Enrollment for the trial began on January 6, 2018 and data are expected to be available by August 2018. CONCLUSIONS This study will contribute to the literature by demonstrating the efficacy of Web-based screenings and brief interventions among Japanese problem drinkers and indicating several possible moderators between the intervention and outcomes. This type of Web-based brief intervention has the possibility of being implemented in Japanese schools and workplaces as a prevention tool. CLINICALTRIAL UMIN Clinical Trials Registry R000034388; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi? recptno=R000034388 (Archived by WebCite at http://www.webcitation.org/6xmOoTfTI) REGISTERED REPORT IDENTIFIER RR1-10.2196/10650

scholarly journals Brief intervention in substance-use among adolescent psychiatric patients: a randomized controlled trial

2009 ◽  
Vol 19 (6) ◽  
pp. 503-511 ◽  
Author(s):  
Javier Goti ◽  
Rosa Diaz ◽  
Lourdes Serrano ◽  
Laura Gonzalez ◽  
Rosa Calvo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Brief Intervention ◽  
Psychiatric Patients ◽  
Controlled Trial ◽  
Randomized Controlled
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