scholarly journals Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Michael L. Alosco ◽  
Asim Z. Mian ◽  
Karen Buch ◽  
Chad W. Farris ◽  
Madeline Uretsky ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Finding ◽  
Chronic Traumatic Encephalopathy ◽  
Magnetic Resonance Imaging Finding ◽  
Microvascular Disease ◽  
Septum Pellucidum ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Cavum Septum Pellucidum

Abstract Background Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, cannot currently be diagnosed during life. Atrophy patterns on magnetic resonance imaging could be an effective in vivo biomarker of CTE, but have not been characterized. Mechanisms of neurodegeneration in CTE are unknown. Here, we characterized macrostructural magnetic resonance imaging features of brain donors with autopsy-confirmed CTE. The association between hyperphosphorylated tau (p-tau) and atrophy on magnetic resonance imaging was examined. Methods Magnetic resonance imaging scans were obtained by medical record requests for 55 deceased symptomatic men with autopsy-confirmed CTE and 31 men (n = 11 deceased) with normal cognition at the time of the scan, all >60 years Three neuroradiologists visually rated regional atrophy and microvascular disease (0 [none]–4 [severe]), microbleeds, and cavum septum pellucidum presence. Neuropathologists rated tau severity and atrophy at autopsy using semi-quantitative scales. Results Compared to unimpaired males, donors with CTE (45/55=stage III/IV) had greater atrophy of the orbital-frontal (mean diff.=1.29), dorsolateral frontal (mean diff.=1.31), superior frontal (mean diff.=1.05), anterior temporal (mean diff.=1.57), and medial temporal lobes (mean diff.=1.60), and larger lateral (mean diff.=1.72) and third (mean diff.=0.80) ventricles, controlling for age at scan (ps<0.05). There were no effects for posterior atrophy or microvascular disease. Donors with CTE had increased odds of a cavum septum pellucidum (OR = 6.7, p < 0.05). Among donors with CTE, greater tau severity across 14 regions corresponded to greater atrophy on magnetic resonance imaging (beta = 0.68, p < 0.01). Conclusions These findings support frontal-temporal atrophy as a magnetic resonance imaging finding of CTE and show p-tau accumulation is associated with atrophy in CTE.

scholarly journals Breast imaging in patients with nipple discharge

2017 ◽  
Vol 50 (6) ◽  
pp. 383-388 ◽  
Author(s):  
Ivie Braga de Paula ◽  
Adriene Moraes Campos
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Imaging Finding ◽  
Magnetic Resonance Imaging Finding ◽  
Nipple Discharge ◽  
Common Symptom ◽  
Resonance Imaging ◽  
Risk Of Malignancy

Abstract Nipple discharge is a common symptom in clinical practice, representing the third leading breast complaint, after pain and lumps. It is usually limited and has a benign etiology. The risk of malignancy is higher when the discharge is uniductal, unilateral, spontaneous, persistent, bloody, or serous, as well as when it is accompanied by a breast mass. The most common causes of pathologic nipple discharge are papilloma and ductal ectasia. However, there is a 5% risk of malignancy, mainly ductal carcinoma in situ. The clinical examination is an essential part of the patient evaluation, allowing benign nipple discharge to be distinguished from suspicious nipple discharge, which calls for imaging. Mammography and ultrasound should be used together as first-line imaging methods. However, mammography has low sensitivity in cases of nipple discharge, because, typically, the lesions are small, are retroareolar, and contain no calcifications. Because the reported sensitivity and specificity of ultrasound, it is important to use the correct technique to search for intraductal lesions in the retroareolar region. Recent studies recommend the use of magnetic resonance imaging in cases of suspicious nipple discharge in which the mammography and ultrasound findings are normal. The most common magnetic resonance imaging finding is non-mass enhancement. Surgery is no longer the only solution for patients with suspicious nipple discharge, because short-time follow-up can be safely proposed.

Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

1993 ◽  
Vol 23 (2) ◽  
pp. 319-322 ◽  
Author(s):  
George J. Jurjus ◽  
Henry A. Nasrallah ◽  
Stephen C. Olson ◽  
Steven B. Schwarzkopf
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Study ◽  
Septum Pellucidum ◽  
Healthy Controls ◽  
Resonance Imaging ◽  
Cavum Septum Pellucidum ◽  
Clinical Difference ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Study

SynopsisMany structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18·9 %, and of all psychotic subjects 18·1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9·7%, P = 0·01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0·02). No clinical difference was found between schizophrenics with or without CSP.

scholarly journals Does functional evaluation and magnetic resonance imaging finding in a case of lumbar canal stenosis co-relate: a study of 50 cases

2017 ◽  
Vol 3 (4) ◽  
pp. 751
Author(s):  
Naushad Hussain ◽  
Nirmal Dhananjay Patil ◽  
Akash Shakya ◽  
Kalpesh Prakash Saindane
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Finding ◽  
Magnetic Resonance Imaging Finding ◽  
Functional Evaluation ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Lumbar Canal Stenosis ◽  
Canal Stenosis ◽  
Severity Of The Disease

<p class="abstract"><strong>Background:</strong> Lumbar canal stenosis is a clinical diagnosis. MRI is used many times for making the diagnosis. But does the severity of MRI findings co-relate with functional status?</p><p class="abstract"><strong>Methods:</strong> 50 cases of central lumbar canal stenosis were included in the study. The MRI findings and Oswestery Disability Index score were compared.<strong></strong></p><p class="abstract"><strong>Results:</strong> 50% of patients with severe ODI score had no Stenosis in the MRI. MRI findings do not co-relate with the functional severity of the disease (p=0.03).</p><p><strong>Conclusions:</strong> MRI and ODI score does not co-relate. This study reinforces the fact that one should always treat the patient and not the MRI. </p>

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