scholarly journals Pancytopenia as an initial manifestation of prostate cancer: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Marcos Antonio Custódio Neto da Silva ◽  
Vitor Pimentel Rodrigues Manhães ◽  
Luadir Gasparotto Júnior ◽  
Daniela Miti Lemos Tsukumo ◽  
Cristina Alba Lalli
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Cancer Metastasis ◽  
Cancer Type ◽  
Initial Manifestation ◽  
Additional Information ◽  
Cancer Management ◽  
Urinary Tract Symptoms ◽  
Prostate Cancer Metastasis ◽  
Tumor Involvement

Abstract Background Prostate adenocarcinoma is the most frequent cancer type among men, followed by skin cancer. Patients with prostate cancer usually present lower urinary tract symptoms due to tumor involvement. Bone marrow invasion is associated with prostate cancer metastasis and is common if blastic lesions in bones are present but is very rare without a large bone involvement and uncommon as initial presentation. Case presentation We present a case of an 86-year-old Caucasian man with bone marrow invasion of prostate cancer without urological or bone-related symptoms and without prostate nodules. His findings were dyspnea, fatigue, and tachycardia. We detail the complete investigation of the case until we found the accurate diagnosis. The patient started treatment, but he had no response and so the oncology team started palliative care. Conclusion Bone marrow invasion as an initial manifestation of prostate cancer is not common, especially if no prostatic lesions are found. This report is important to provide additional information about prostate cancer management.

scholarly journals Multivariate competing endogenous RNA network characterization for cancer MicroRNA biomarker discovery: a novel bioinformatics model with application to prostate cancer metastasis

2022 ◽  
Author(s):  
Yuxin Lin ◽  
Xin Qi ◽  
Jing Chen ◽  
Bairong Shen
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Biomarker Discovery ◽  
Characteristic Curve ◽  
Mapk Signaling ◽  
Competing Endogenous Rna ◽  
Cancer Management ◽  
Cerna Network ◽  
Prostate Cancer Metastasis ◽  
Underlying Mechanisms

Abstract Background MicroRNAs (miRNAs) are post-transcriptional regulators with the potential as biomarkers for cancer management. Data-driven competing endogenous RNA (ceRNA) network modeling is an effective way to decipher the complex interplay between miRNAs and spongers. However, no general rules are discovered for ceRNA network-based biomarker prioritization. Methods and Results In this study, a novel bioinformatics model was developed by integrating gene expression with multivariate miRNA-target data for ceRNA network-based biomarker discovery. Compared with traditional methods, the structural vulnerability in human lncRNA-miRNA-mRNA network was comprehensively analyzed, and the single-line regulatory or competing mode among miRNAs, lncRNAs and mRNAs was characterized and quantified as statistical evidence for miRNA biomarker identification. The application of this model to prostate cancer (PCa) metastasis identified a total of 12 miRNAs as putative biomarkers from metastatic PCa-specific lncRNA-miRNA-mRNA network and nine of them have been previously reported as biomarkers for PCa metastasis. The receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p, miR-130a-3p, and miR-363-3p as novel candidates for predicting PCa metastasis. Moreover, PCa-associated pathways such as prostate cancer signaling, ERK/MAPK signaling, and TGF-β signaling were significantly enriched by targets of identified miRNAs, indicating the underlying mechanisms of miRNAs in PCa carcinogenesis. Conclusions A novel ceRNA-based bioinformatics model was proposed and applied to screen candidate miRNA biomarkers for PCa metastasis. Functional validations using human samples and clinical data will be performed for future translational studies on the identified miRNAs.

scholarly journals Renal colic secondary to ureteral metastasis: Rare presenting manifestation of prostate cancer

2020 ◽  
Vol 7 (7) ◽  
pp. 575-577
Author(s):  
Mircea Valentin Pirvut ◽  
Ionela Mihai ◽  
Alexandra Ioana Micu ◽  
Alexandru Tiberiu Priporeanu ◽  
Vasile Baisanu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Urinary Tract ◽  
Cancer Metastasis ◽  
Renal Colic ◽  
Upper Urinary Tract ◽  
Flexible Ureteroscopy ◽  
Prostate Needle Biopsy ◽  
Urinary Tract Symptoms ◽  
Prostate Cancer Metastasis ◽  
History Of

Objective:  Ureteral metastasis of prostate cancer is a very rare pathology, that can be confused with an upper urinary tract urothelial carcinoma, with great implications in the surgical management and therapy of the disease. Case: A 56-years old male patient admitted to the emergency room with 2 weeks history of left flank pain without low urinary tract symptoms or hematuria. PSA level was 43,4 ng/ml. The patient underwent prostate needle biopsy and ureteral biopsy using flexible ureteroscopy, after the Lich-Gregoire ureterovesical reimplantation. In this case, renal colic as the first symptom of a ureteral metastasis secondary to prostate cancer is extremely rare which diagnosed in the patient. Conclusion: Neoureterocystostomy is a safe and effective treatment for ureteral obstruction due to prostate cancer metastasis, with low morbidity and significant benefits in terms of quality of life for patients with life expectancy more than 10 years.

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