scholarly journals Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Nikos Efthimiou ◽  
Kris Thielemans ◽  
Elise Emond ◽  
Chris Cawthorne ◽  
Stephen J. Archibald ◽  
...  
2021 ◽  
Vol 11 (16) ◽  
pp. 7548
Author(s):  
Luca Presotto ◽  
Valentino Bettinardi ◽  
Elisabetta De Bernardi

Background: Time-of-Flight (TOF) is a leading technological development of Positron Emission Tomography (PET) scanners. It reduces noise at the Maximum-Likelihood solution, depending on the coincidence–timing–resolution (CTR). However, in clinical applications, it is still not clear how to best exploit TOF information, as early stopped reconstructions are generally used. Methods: A contrast-recovery (CR) matching rule for systems with different CTRs and non-TOF systems is theoretically derived and validated using (1) digital simulations of objects with different contrasts and background diameters, (2) realistic phantoms of different sizes acquired on two scanners with different CTRs. Results: With TOF, the CR matching rule prescribes modifying the iterations number by the CTRs ratio. Without TOF, the number of iterations depends on the background dimension. CR matching was confirmed by simulated and experimental data. With TOF, image noise followed the square root of the CTR when the rule was applied on simulated data, while a significant reduction was obtained on phantom data. Without TOF, preserving the CR on larger objects significantly increased the noise. Conclusions: TOF makes PET reconstructions less dependent on background dimensions, thus, improving the quantification robustness. Better CTRs allows performing fewer updates, thus, maintaining accuracy while minimizing noise.


Sensors ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 3270 ◽  
Author(s):  
Baris Satar ◽  
Gokhan Soysal ◽  
Xue Jiang ◽  
Murat Efe ◽  
Thiagalingam Kirubarajan

Conventional methods such as matched filtering, fractional lower order statistics cross ambiguity function, and recent methods such as compressed sensing and track-before-detect are used for target detection by passive radars. Target detection using these algorithms usually assumes that the background noise is Gaussian. However, non-Gaussian impulsive noise is inherent in real world radar problems. In this paper, a new optimization based algorithm that uses weighted l 1 and l 2 norms is proposed as an alternative to the existing algorithms whose performance degrades in the presence of impulsive noise. To determine the weights of these norms, the parameter that quantifies the impulsiveness level of the noise is estimated. In the proposed algorithm, the aim is to increase the target detection performance of a universal mobile telecommunication system (UMTS) based passive radars by facilitating higher resolution with better suppression of the sidelobes in both range and Doppler. The results obtained from both simulated data with α stable distribution, and real data recorded by a UMTS based passive radar platform are presented to demonstrate the superiority of the proposed algorithm. The results show that the proposed algorithm provides more robust and accurate detection performance for noise models with different impulsiveness levels compared to the conventional methods.


2003 ◽  
Author(s):  
S. Pavlopoulos ◽  
G. Tzanakos ◽  
M. Bhatia

Stat ◽  
2015 ◽  
Vol 4 (1) ◽  
pp. 304-319 ◽  
Author(s):  
Alexey Miroshnikov ◽  
Zheng Wei ◽  
Erin Marie Conlon

2004 ◽  
Vol 2004 (8) ◽  
pp. 421-429 ◽  
Author(s):  
Souad Assoudou ◽  
Belkheir Essebbar

This note is concerned with Bayesian estimation of the transition probabilities of a binary Markov chain observed from heterogeneous individuals. The model is founded on the Jeffreys' prior which allows for transition probabilities to be correlated. The Bayesian estimator is approximated by means of Monte Carlo Markov chain (MCMC) techniques. The performance of the Bayesian estimates is illustrated by analyzing a small simulated data set.


1984 ◽  
Vol 31 (1) ◽  
pp. 605-608 ◽  
Author(s):  
D. C. Ficke ◽  
D. E. Beecher ◽  
G. R. Hoffman ◽  
T. J. Holmes ◽  
M. M. Ter-Pogossian

1993 ◽  
Vol 115 (2) ◽  
pp. 193-201 ◽  
Author(s):  
R. A. Ibrahim ◽  
B. H. Lee ◽  
A. A. Afaneh

Stochastic bifurcation in moments of a clamped-clamped beam response to a wide band random excitation is investigated analytically, numerically, and experimentally. The nonlinear response is represented by the first three normal modes. The response statistics are examined in the neighborhood of a critical static axial load where the normal mode frequencies are commensurable. The analytical treatment includes Gaussian and non-Gaussian closures. The Gaussian closure fails to predict bifurcation of asymmetric modes. Both non-Gaussian closure and numerical simulation yield bifurcation boundaries in terms of the axial load, excitation spectral density level, and damping ratios. The results of both methods are in good agreement only for symmetric response characteristics. In the neighborhood of the critical bifurcation parameter the Monte Carlo simulation yields strong nonstationary mean square response for the asymmetric mode which is not directly excited. Experimental and Monte Carlo simulation exhibit nonlinear features including a shift of the resonance peak in the response spectra as the excitation level increases. The observed shift is associated with a widening effect in the response bandwidth.


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