The Pathogenesis and Characterization of Oral Mucositis Associated With Cancer Therapy: Nursing Interventions and Supportive Care for the Prevention and Treatment of Oral Mucositis Associated With Cancer Treatment

2004 ◽  
Vol 31 (0) ◽  
pp. 37-39
Keyword(s):  
Cancer Therapy ◽  
Supportive Care ◽  
Cancer Treatment ◽  
Oral Mucositis ◽  
Nursing Interventions ◽  
Prevention And Treatment

scholarly journals Oral Microbiome and Cancer Therapy-Induced Oral Mucositis

2019 ◽  
Vol 2019 (53) ◽  
Author(s):  
Jean-Luc C Mougeot ◽  
Craig B Stevens ◽  
Darla S Morton ◽  
Michael T Brennan ◽  
Farah B Mougeot
Keyword(s):  
Cancer Therapy ◽  
Oral Mucositis ◽  
Human Microbiome ◽  
Holistic Approach ◽  
Human Microbiome Project ◽  
Oral Microbiome ◽  
Commensal Microbiota ◽  
Intestinal Mucositis

AbstractCharacterization of the role of oral microbiome in cancer therapy-induced oral mucositis (CTOM) is critical in preventing the clinically deleterious effects on patients’ health that are associated with CTOM. Funding initiatives related to the National Institutes of Health human microbiome project have resulted in groundbreaking advancements in biology and medicine during the last decade. These advancements have shown that a human being is in fact a superorganism made of human cells and associated symbiotic or commensal microbiota. In this review, we describe the state of science as it relates to fundamental knowledge on oral microbiome and its role in CTOM. We also discuss how state-of-the-art technologies and systems biology tools may be used to help tackle the difficult challenges ahead to develop effective treatments or preventive therapies for oral mucositis. We make a clear distinction between disease processes pertaining to the oral microbiome, which includes opportunistic pathogens that may be defined as pathobionts, and those infectious disease processes initiated by exogenous pathogens. We also explored the extent to which knowledge from the gastrointestinal tract in disease and intestinal mucositis could help us better understand CTOM pathobiology. Finally, we propose a model in which the oral microbiome participates in the current five-step CTOM pathobiology model. With the advent of more sophisticated metagenomics technologies and methods of analysis, much hope lies ahead to implement an effective holistic approach to treat cancer patients affected by CTOM.

scholarly journals Oral mucositis in cancer treatment: Natural history, prevention and treatment

2014 ◽  
Vol 2 (3) ◽  
pp. 337-340 ◽  
Author(s):  
MARIA INES DA CRUZ CAMPOS ◽  
CELSO NEIVA CAMPOS ◽  
FERNANDO MONTEIRO AARESTRUP ◽  
BEATRIZ JULIÃO VIEIRA AARESTRUP
Keyword(s):  
Natural History ◽  
Cancer Treatment ◽  
Oral Mucositis ◽  
Prevention And Treatment

scholarly journals Oral microbiota versus oral mucositis during cancer treatment: a review

HU Revista ◽  
2020 ◽  
Vol 46 ◽  
Author(s):  
Izabella Henrichs Ribeiro ◽  
Júlia Ferigatto ◽  
Dionéia Evangelista Cesar ◽  
Rodrigo Luiz Fabri ◽  
Ana Carolina Morais Apolônio
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Head And Neck ◽  
Oral Mucositis ◽  
Head And Neck Neoplasms ◽  
Data Extraction ◽  
Oral Microbiota ◽  
Medical Subject Heading ◽  
Radiation Induced

Introduction: Oral microbiota has been implicated on oral mucositis (OM) that occurs during cancer therapy, however without consensus. Objective: This study, aimed to establish, through a review, the association between oral microbiota and OM at head and neck cancer therapy (HNCT). Material and methods: The search of PubMed was performed considering 2008-2018 period, and the descriptors “oral mucositis” and “oral microbiota” in subheadings etiology and microbiology into the Medical Subject Heading (MeSH) “Head and Neck Neoplasms”. The conducting question was “Is there an oral dysbiosis during HNCT associated with OM?”. Results: 22 articles were selected under two steps of data extraction: articles that evaluated de oral microbiota during HNCT (n=13), and articles that also focused in OM (n=9). Conclusion: The evidence presented in the literature suggests associations of oral microbiota dysbiosis with the progression and worsening of radiation-induced OM. However, to define a microbial core for the disease, future standardized studies are required.

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