Autoimmune Hemolytic Anemia: A Case Study Presentation

2021 ◽  
Vol 25 (6) ◽  
pp. 633-636
Author(s):  
Jessica Shelly ◽  
Michelle Kull
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia

scholarly journals Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity

2013 ◽  
Vol 6 ◽  
pp. CCRep.S11469 ◽  
Author(s):  
Amruth R. Palla ◽  
Farhad Khimani ◽  
Michael D. Craig
Keyword(s):  
Literature Review ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Interesting Case ◽  
Clinical Entity ◽  
Direct Antiglobulin Test ◽  
Complement C3 ◽  
Igg Antibodies ◽  
Antiglobulin Test

Polygenic IgG autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia (WAIHA). In some of these cases, complement (C3) proteins accompany the IgG antibodies. WAIHA mediated by C3 alone is relatively rare. We present an interesting case of WAIHA with a direct antiglobulin test (DAT) positive for C3 but negative for IgG in a 79-year-old woman and perform an analytical literature review of the incidence and severity of this clinical entity.

scholarly journals Dehydrated hereditary stomatocytosis with new missense mutations in PIEZO1 through the use of next-generation sequencing panel

2021 ◽  
Author(s):  
Sultan Aydin Koker ◽  
Tuba Karapınar ◽  
Paola BIANCHI ◽  
Yeşim Oymak ◽  
Elisa Fermo ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Missense Mutation ◽  
Hemolytic Anemia ◽  
Male Patient ◽  
Autoimmune Hemolytic Anemia ◽  
Missense Mutations ◽  
Next Generation ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

In this case study, we report an 11-year-old male patient who had jaundice, hepatosplenomegaly, and chronic mild congenital non-autoimmune hemolytic anemia. In our patient, a novel homozygous missense mutation in the PIEZO1 gene was detected using a gene-targeted Next-Generation Sequencing panel: c.3364G>A (p.Glu1122Lys), confirming the diagnosis of DHS.

scholarly journals Chronic Lymphocytic Leukemia, Hypogammaglobulinemia and Autoimmune Hemolytic Anemia— An Experiment of Nature

Blood ◽  
1960 ◽  
Vol 15 (5) ◽  
pp. 748-757 ◽  
Author(s):  
ANTHONY V. PISCIOTTA ◽  
LOUIS F. JERMAIN ◽  
JEAN E. HINZ
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Gamma Globulin ◽  
Lymphocytic Leukemia ◽  
Chronic Lymphatic Leukemia ◽  
Lymphatic Leukemia ◽  
Normal Human ◽  
Human Gamma Globulin

Abstract 1. The case study is presented of a 75 year old man who had chronic lymphatic leukemia, autoimmune hemolytic anemia and hypogammaglobulinemia. The positive antiglobulin reaction with serum made from gamma globulin and the neutralization of the antiglobulin reaction with human gamma globulin demonstrated that this patient’s erythrocytes were coated with gamma globulin. 2. There was a normal survival time of I131-labeled normal human gamma globulin, suggesting defective synthesis of gamma globulin. Failure to demonstrate radioactivity on the patient’s erythrocytes when I131-labeled normal gamma globulin was given signified that normal human gamma globulin has no affinity in vivo for the patient’s red cells and that the erythrocyte-coating protein was derived from a source endogenous to the patient. 3. These relationships favor an immunologic mechanism in the development of an antiglobulin reaction in this patient.

Hyperleukocytosis: A Rare Manifestation of Autoimmune Hemolytic Anemia

2020 ◽  
Keyword(s):  
Hemolytic Anemia ◽  
Mycoplasma Pneumoniae ◽  
Autoimmune Hemolytic Anemia ◽  
Blood Cells ◽  
White Blood Cells ◽  
Vital Signs ◽  
Antibody Testing ◽  
Cell Surface Antigens ◽  
Rare Manifestation

Autoimmune hemolytic anemia (AIHA) is described by destruction of Red Blood Cells (RBCs) as a result of binding of antibodies to red blood cell surface antigens. White blood cells are usually normal and hyperleukocytosis is rare. The most common microorganism that has been associated with these hemolytic processes is Mycoplasma pneumoniae. We presented a case study, a 4-year-old boy child who was diagnosed AIHA by warm antibody testing with high leukocyte count. The patient was treated with methylprednisolone, intravenous immunoglobulin and clarithromycin. During treatment, the leukocytosis became normal. The clinical condition and vital signs improved. The purpose of this study was to highlight hyperleukocytosis in AIHA caused by Mycoplasma pneumoniae. Keywords: Autoimmune Hemolytic Anemia, Child, Leukocyte, Mycoplasma.

Autoimmune hemolytic anemia

1975 ◽  
Vol 135 (10) ◽  
pp. 1293-1300 ◽  
Author(s):  
J. V. Dacie
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia

Giant cell hepatitis and Coomb’s positive autoimmune hemolytic anemia: a case report and literature review

2014 ◽  
Vol 25 (1) ◽  
Author(s):  
Hasan M. Isa ◽  
◽  
Lina F. Al Ali ◽  
Afaf M. Mohamed ◽  
Rawia M. Hamad ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Giant Cell ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Giant Cell Hepatitis

Anti‐plasma cell treatment in refractory autoimmune hemolytic anemia in a child with multivisceral transplant

2021 ◽  
Author(s):  
Shahira Ghobrial ◽  
Corina Elena Gonzalez ◽  
Stuart Kaufman ◽  
Nada Yazigi ◽  
Cal Matsumoto ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Plasma Cell ◽  
Autoimmune Hemolytic Anemia

scholarly journals Autoimmune hemolytic anemia during long‐term administration of nivolumab for metastatic melanoma

2021 ◽  
Author(s):  
Koji Nakajima ◽  
Ayumi Korekawa ◽  
Daiki Rokunohe ◽  
Hajime Nakano ◽  
Daisuke Sawamura
Keyword(s):  
Metastatic Melanoma ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
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