The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles

Lupus ◽  
2003 ◽  
Vol 12 (11) ◽  
pp. 846-850 ◽  
Author(s):  
A Jönsen ◽  
A A Bengtsson ◽  
O Nived ◽  
B Ryberg ◽  
L Truedsson ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cerebrospinal Fluid ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Cytokine Profiles ◽  
Neuropsychiatric Systemic Lupus Erythematosus

scholarly journals A Patient with Systemic Lupus Erythematosus Complicated by Neurological Symptoms of Toluene Poisoning

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Kentaro Isoda ◽  
Tohru Takeuchi ◽  
Shigeki Makino ◽  
Toshiaki Hanafusa
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cerebrospinal Fluid ◽  
Lupus Erythematosus ◽  
Brain Magnetic Resonance Imaging ◽  
Neurological Symptoms ◽  
Emission Computed Tomography ◽  
Systemic Lupus ◽  
Laboratory Findings ◽  
Neuropsychiatric Systemic Lupus Erythematosus ◽  
Dsdna Antibody

We report a patient with systemic lupus erythematosus complicated by toluene poisoning. She had erythema, alopecia, arthralgia, and various neurological symptoms. Laboratory findings showed leukocytopenia, low levels of complements, and anti-dsDNA antibody. However, normal interleukin-6 level and IgG index of cerebrospinal fluid and brain magnetic resonance imaging and single photon emission computed tomography findings suggested that her neurological symptoms were caused by metabolic disorder but not neuropsychiatric systemic lupus erythematosus. Erythema, alopecia, and arthralgia improved rapidly after administration of prednisolone and tacrolimus, whereas neurological symptoms improved only gradually. Because of a history of exposure to toluene, her neurological symptoms were considered to be due to toluene poisoning. The differentiation of toluene poisoning from neuropsychiatric systemic lupus erythematosus based on symptoms is difficult because both induce various neuropsychiatric disorders. Laboratory findings of cerebrospinal fluid, radiological findings, and medical interview were useful for differentiation of toluene poisoning from neuropsychiatric systemic lupus erythematosus.

Up-regulation of C3 levels in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus patients

Immunobiology ◽  
2016 ◽  
Vol 221 (10) ◽  
pp. 1210-1211
Author(s):  
Tomoyuki Asano ◽  
Shuzo Sato ◽  
Hiroko Kobayashi ◽  
Yoshinobu Kariya ◽  
Hiromi Ito ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cerebrospinal Fluid ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Neuropsychiatric Systemic Lupus Erythematosus

Association of anti-NR2 and U1RNP antibodies with neurotoxic inflammatory mediators in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (13) ◽  
pp. 1673-1682
Author(s):  
Seiko Kondo-Ishikawa ◽  
Takao Fujii ◽  
Nozomi Ishigooka ◽  
Kosaku Murakami ◽  
Ran Nakashima ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cerebrospinal Fluid ◽  
Inflammatory Mediators ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Double Positive ◽  
Neuropsychiatric Systemic Lupus Erythematosus ◽  
Cytokine Analysis ◽  
Ifn Γ ◽  
Multiplex Cytokine

Background Autoantibodies (auto Abs) and inflammatory mediators (IMs) in cerebrospinal fluid (CSF) may be involved in the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE). It is suggested that anti- N-methyl D-aspartate receptor NR2 subunit (NR2) Ab can develop NP manifestation after blood–brain barrier (BBB) abruption. We also reported the association between NPSLE and CSF anti-U1RNP Ab. In the present study, combined effects of CSF anti-NR2 and anti-U1RNP Abs on IMs in patients with NPSLE were examined. Methods CSF samples were collected from 69 patients with NPSLE and 13 non-NPSLE controls. CSF anti-NR2 and anti-U1RNP Abs were determined using ELISA. Levels of IL-6, IL-8, and monokine induced by IFN-γ (MIG) in CSF were measured by quantitative multiplex cytokine analysis. Results CSF IL-6 levels were higher in CSF anti-NR2-positive than in CSF anti-NR2-negative patients ( p = 0.003) and non-NPSLE controls ( p = 0.015) and were positively correlated with anti-NR2 titer ( r = 0.42). CSF IL-8 levels were higher in CSF anti-U1RNP-positive than in CSF anti-U1RNP-negative patients ( p = 0.041). CSF MIG levels were more elevated in CSF anti-NR2-positive ( p = 0.043) and anti-U1RNP-positive patients ( p = 0.029) than in non-NPSLE controls. Additionally, in double positive (DP; both anti-NR2 and U1RNP Ab positive) group, CSF IL-6 and MIG levels were significantly higher than in the double negative (DN; both anti-NR2 and U1RNP Ab negative) group. However, combined effect of both Abs on IM elevation and clinical manifestation was not clear. Conclusions CSF anti-NR2 and anti-U1RNP Abs have different effects on the elevation of CSF IM levels in patients with NPSLE. Additional effect of anti-U1RNP Abs on anti-NR2 Ab-mediated NP manifestation, however, was not recognized in our study.

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