Partial agonists of dopamine receptors: receptor theory and the dopamine hypothesis of psychosis

2021 ◽  
pp. 1-4 ◽  
Author(s):  
John Cookson ◽  
Jonathan Pimm
Keyword(s):  
Dopamine Receptors ◽  
Mechanism Of Action ◽  
Main Mechanism ◽  
Partial Agonism ◽  
Partial Agonists ◽  
Psychiatric Drugs ◽  
Receptor Theory ◽  
Dopamine Hypothesis

SUMMARY This article discusses dopamine partial agonism, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazole and cariprazine. It outlines the principles of receptor theory and the structure of dopamine receptors; characterises agonists, antagonists and partial agonists; and summarises the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression.

Pharmacological approaches to treatment

2020 ◽  
pp. 487-495
Author(s):  
Stefan Leucht ◽  
Andrea Cipriani ◽  
Toshi A. Furukawa
Keyword(s):  
Psychotic Disorder ◽  
Mechanism Of Action ◽  
Pharmacological Treatment ◽  
Antipsychotic Drugs ◽  
Psychotic Disorders ◽  
Psychotic Symptoms ◽  
Dopamine Antagonists ◽  
Partial Agonists ◽  
The Common

Antipsychotic drugs should be efficacious for all psychotic symptoms, whether they occur in schizophrenia, depression, mania, or any other psychotic disorder. All currently marketed antipsychotic drugs are dopamine antagonists or partial agonists, making the role of dopamine blockade in this context the most likely mechanism of action. Antipsychotics show efficacy in treatment and in maintenance across the common psychosis diagnoses, especially when looking across large metanalyses. Yet, there is an important imbalance as to how well the pharmacological treatment of the different psychotic disorders have been addressed in the literature, with schizophrenia being predominant.

SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION

1965 ◽  
Vol 49 (1) ◽  
pp. 28-38
Author(s):  
M. Grönroos ◽  
E. Mäkinen ◽  
K. Lahtinen ◽  
R. Tirri
Keyword(s):  
Mechanism Of Action ◽  
Biological Effect ◽  
Female Rats ◽  
Histological Picture ◽  
Peripheral Effect ◽  
Pituitary Secretion

ABSTRACT The effect of reserpine on the secretion of FSH and LH was studied as well as the role of the peripheral effect of reserpine after hypophysectomy. The results in the unoperated animals suggest that reserpine inhibits the pituitary secretion of both FSH and LH. Both these hormones combined with reserpine had a very different biological effect than was seen without reserpine. HCG (LH-like) and particularly PMS (FSH-like) hormones combined with reserpine caused definite enlargement of the ovaries. In the hypophysectomized groups, the effect of the PMS and HCG hormones administered together with reserpine or without it was the same with regard to the weight of the ovaries, but not with regard to their histological picture. On the basis of these results, reserpine may be said to have a peripheral effect although the nature of its mechanism of action is difficult to state. Reserpine probably affects the ovaries by inhibiting the follicular cycle and, consequently, the formation of new and more mature follicles.

Role of Flavonoids in Neurodegenerative Disorders with Special Emphasis on Tangeritin

2019 ◽  
Vol 18 (8) ◽  
pp. 581-597 ◽  
Author(s):  
Ambreen Fatima ◽  
Yasir Hasan Siddique
Keyword(s):  
Medicinal Plants ◽  
Mechanism Of Action ◽  
Neurodegenerative Disorders ◽  
Treatment Strategies ◽  
Dietary Supplementation ◽  
Plant Polyphenols ◽  
Promising Candidate ◽  
Naturally Occurring ◽  
The Brain

Flavonoids are naturally occurring plant polyphenols found universally in all fruits, vegetables and medicinal plants. They have emerged as a promising candidate in the formulation of treatment strategies for various neurodegenerative disorders. The use of flavonoid rich plant extracts and food in dietary supplementation have shown favourable outcomes. The present review describes the types, properties and metabolism of flavonoids. Neuroprotective role of various flavonoids and the possible mechanism of action in the brain against the neurodegeneration have been described in detail with special emphasis on the tangeritin.

Novel Approaches in the Treatment of Antipsychotic-Induced Hyperprolactinemia:The Role of Partial Agonists of D2 Dopaminergic Receptors

2010 ◽  
Vol 4 (3) ◽  
pp. 230-240 ◽  
Author(s):  
Domenico De Berardis ◽  
Tiziano Acciavatti ◽  
Daniela Campanella ◽  
Nicola Serroni ◽  
Luigi Olivieri ◽  
...  
Keyword(s):  
Dopaminergic Receptors ◽  
Partial Agonists ◽  
Novel Approaches

scholarly journals The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

2021 ◽  
pp. 107916
Author(s):  
Brandán Pedre ◽  
Uladzimir Barayeu ◽  
Daria Ezeriņa ◽  
Tobias P. Dick
Keyword(s):  
Mechanism Of Action ◽  
Sulfur Species ◽  
Sulfane Sulfur

Role of cyclic nucleotides in the mechanism of action of enkephalins

1982 ◽  
Vol 93 (3) ◽  
pp. 265-267
Author(s):  
M. Ya. Maizelis ◽  
A. L. Zabludovskii ◽  
S. N. Shikhov
Keyword(s):  
Mechanism Of Action ◽  
Cyclic Nucleotides

The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs

2001 ◽  
Vol 50 (11) ◽  
pp. 856-872 ◽  
Author(s):  
Elisabeth B Binder ◽  
Becky Kinkead ◽  
Michael J Owens ◽  
Charles B Nemeroff
Keyword(s):  
Mechanism Of Action ◽  
Antipsychotic Drugs
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