Two Stage Design in a Community Survey

1986 ◽  
Vol 149 (1) ◽  
pp. 88-97 ◽  
Author(s):  
J. L. Vázquez-Barquero ◽  
J. F. Díez-Manrique ◽  
C. Peña ◽  
R. G. Quintanal ◽  
M. Labrador Lopez
Keyword(s):  
Great Reduction ◽  
Scoring System ◽  
Screening Instrument ◽  
Community Survey ◽  
Two Stage ◽  
Stage Design ◽  
Predictive Values ◽  
Transient States ◽  
Global Efficiency ◽  
Two Stage Design

By comparison with the PSE-ID system, we showed that the GHQ-60 could be used with good results as a screening instrument in the first of a two stage community survey. Unlike the sensitivity and negative predictive values, the specificity and positive predictive rates reach low figures in this study. The global efficiency and positive and negative predictive values of the test are significantly improved by raising its cut-off score, but at the expense of great reduction in sensitivity. The revised scoring system failed to provide better prediction of caseness' than conventional scoring. The GHQ does not distinguish fully between persons in the community afflicted by ‘transient states of distress' and those whose symptoms would classify them as cases' by the PSE.

Tubular electrostatic precipitators of two-stage design

1981 ◽  
Vol 6 (1-6) ◽  
pp. 239-244 ◽  
Author(s):  
Harish S. Surati ◽  
Michael R. Beltran ◽  
Isaac Raigorodsky
Keyword(s):  
Two Stage ◽  
Stage Design ◽  
Electrostatic Precipitators ◽  
Two Stage Design

scholarly journals Bayesian Two-Stage Adaptive Design in Bioequivalence

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Shengjie Liu ◽  
Jun Gao ◽  
Yuling Zheng ◽  
Lei Huang ◽  
Fangrong Yan
Keyword(s):  
Statistical Power ◽  
Adaptive Design ◽  
Type I Error ◽  
Probability Model ◽  
Type I ◽  
Two Stage ◽  
Stage Design ◽  
Estimation Strategy ◽  
Drug Products ◽  
Two Stage Design

AbstractBioequivalence (BE) studies are an integral component of new drug development process, and play an important role in approval and marketing of generic drug products. However, existing design and evaluation methods are basically under the framework of frequentist theory, while few implements Bayesian ideas. Based on the bioequivalence predictive probability model and sample re-estimation strategy, we propose a new Bayesian two-stage adaptive design and explore its application in bioequivalence testing. The new design differs from existing two-stage design (such as Potvin’s method B, C) in the following aspects. First, it not only incorporates historical information and expert information, but further combines experimental data flexibly to aid decision-making. Secondly, its sample re-estimation strategy is based on the ratio of the information in interim analysis to total information, which is simpler in calculation than the Potvin’s method. Simulation results manifested that the two-stage design can be combined with various stop boundary functions, and the results are different. Moreover, the proposed method saves sample size compared to the Potvin’s method under the conditions that type I error rate is below 0.05 and statistical power reaches 80 %.

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