scholarly journals Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei

2015 ◽  
Vol 57 (2) ◽  
pp. 219-232 ◽  
Author(s):  
Adriana Esteves ◽  
Anja Knoll-Gellida ◽  
Lucia Canclini ◽  
Maria Cecilia Silvarrey ◽  
Michèle André ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Binding Proteins ◽  
Dietary Fatty Acids ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding

scholarly journals Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins

1991 ◽  
Vol 286 (1) ◽  
pp. 300-309 ◽  
Author(s):  
Gyorgy Nemecz ◽  
Timothy Hubbell ◽  
John R. Jefferson ◽  
John B. Lowe ◽  
Friedhelm Schroeder
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Binding Proteins ◽  
Fatty Acid Binding Proteins ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding

Fatty acid binding sites of rodent adipocyte and heart fatty acid binding proteins: characterization using fluorescent fatty acids

Biochemistry ◽  
1990 ◽  
Vol 29 (40) ◽  
pp. 9305-9311 ◽  
Author(s):  
Margo G. Wootan ◽  
Nathan M. Bass ◽  
David A. Bernlohr ◽  
Judith Storch
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Binding Sites ◽  
Binding Proteins ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding

scholarly journals Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis

2011 ◽  
Vol 300 (5) ◽  
pp. G803-G814 ◽  
Author(s):  
William Stacy Lagakos ◽  
Angela Marie Gajda ◽  
Luis Agellon ◽  
Bert Binas ◽  
Victor Choi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Null Models ◽  
Dietary Fatty Acids ◽  
Fat Free Mass ◽  
Whole Body ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding ◽  
Triacylglycerol Synthesis

It has long been known that mammalian enterocytes coexpress two members of the fatty acid-binding protein (FABP) family, the intestinal FABP (IFABP) and the liver FABP (LFABP). Both bind long-chain fatty acids and have similar though not identical distributions in the intestinal tract. While a number of in vitro properties suggest the potential for different functions, the underlying reasons for expression of both proteins in the same cells are not known. Utilizing mice genetically lacking either IFABP or LFABP, we directly demonstrate that each of the enterocyte FABPs participates in specific pathways of intestinal lipid metabolism. In particular, LFABP appears to target fatty acids toward oxidative pathways and dietary monoacylglycerols toward anabolic pathways, while IFABP targets dietary fatty acids toward triacylglycerol synthesis. The two FABP-null models also displayed differences in whole body response to fasting, with LFABP-null animals losing less fat-free mass and IFABP-null animals losing more fat mass relative to wild-type mice. The metabolic changes observed in both null models appear to occur by nontranscriptional mechanisms, supporting the hypothesis that the enterocyte FABPs are specifically trafficking their ligands to their respective metabolic fates.

The binding affinity of fatty acid-binding proteins from human, pig and rat liver for different fluorescent fatty acids and other ligands

1989 ◽  
Vol 21 (4) ◽  
pp. 407-418 ◽  
Author(s):  
Roger A. Peeters ◽  
Monique A.P.M. in't Groen ◽  
Marielle P. de Moel ◽  
Herman T.B. Van Moerkerk ◽  
Jacques H. Veerkamp
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Binding Affinity ◽  
Rat Liver ◽  
Binding Proteins ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding

scholarly journals 14-P005 The role of fatty acid binding proteins and polyunsaturated fatty acids in hippocampal neurogenesis

2009 ◽  
Vol 126 ◽  
pp. S240
Author(s):  
Noriko Osumi ◽  
Miho Matsumata ◽  
Nobuyuki Sakayori ◽  
Motoko Maekawa ◽  
Takeo Yoshikawa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Binding Proteins ◽  
Hippocampal Neurogenesis ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding

Binding of Fatty Acids and Peroxisome Proliferators to Orthologous Fatty Acid Binding Proteins from Human, Murine, and Bovine Liver†

Biochemistry ◽  
2000 ◽  
Vol 39 (6) ◽  
pp. 1469-1474 ◽  
Author(s):  
Christian Wolfrum ◽  
Torsten Börchers ◽  
James C. Sacchettini ◽  
Friedrich Spener
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Binding Proteins ◽  
Bovine Liver ◽  
Fatty Acid Binding Proteins ◽  
Peroxisome Proliferators ◽  
Fatty Acid Binding
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