Neuroprotection by NGF in the PC12 In Vitro OGD Model: Involvement of Mitogen-Activated Protein Kinases and Gene Expression

2005 ◽  
Vol 1053 (1) ◽  
pp. 84-96 ◽  
Author(s):  
R. TABAKMAN
Keyword(s):  
Gene Expression ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

Fibronectin Gene Expression in Aortic Regurgitation: Relative Roles of Mitogen-Activated Protein Kinases

Cardiology ◽  
2009 ◽  
Vol 113 (4) ◽  
pp. 291-298 ◽  
Author(s):  
Sharada L. Truter ◽  
Daniel F. Catanzaro ◽  
Phyllis G. Supino ◽  
Anuj Gupta ◽  
John Carter ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinases ◽  
Aortic Regurgitation ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

Campylobacter jejuni activates mitogen-activated protein kinases in Caco-2 cell monolayers and in vitro infected primary human colonic tissue

Microbiology ◽  
2005 ◽  
Vol 151 (8) ◽  
pp. 2765-2772 ◽  
Author(s):  
Amanda MacCallum ◽  
Graham Haddock ◽  
Paul H. Everest
Keyword(s):  
Protein Kinases ◽  
Campylobacter Jejuni ◽  
Inflammatory Responses ◽  
Host Responses ◽  
Epithelial Cell Line ◽  
Colonic Tissue ◽  
Mitogen Activated Protein Kinases ◽  
Cell Monolayers ◽  
Mitogen Activated Protein

The mitogen-activated protein kinases (MAPKs) play a central role in many host signalling pathways. These signalling proteins are known to be involved in host responses against invasive bacteria including generation of chemotactic and inflammatory cytokines. It was hypothesized that Campylobacter jejuni may activate MAPKs, as intestinal infection may induce a clinical and pathological picture of acute colonic inflammation. Infection of Caco-2 cell monolayers (human colonic epithelial cell line) and human colonic tissue with C. jejuni in vitro demonstrated increased MAPK activity for ERK 1/2 (p44/42 MAPK), JNK and p38 MAPKs. Kinase activity and phosphorylated forms were increased in infected Caco-2 cells and human colonic explants, suggesting that these pathways are important in inflammatory responses induced by C. jejuni in man.

Role of the Mitogen-Activated Protein Kinases in Cytokine-Mediated Inhibition of Insulin Gene Expression

2006 ◽  
Vol 54 (3) ◽  
pp. 132-142 ◽  
Author(s):  
Catherine V.T. Chin-Chance ◽  
Marsha V. Newman ◽  
Amy Aronovitz ◽  
Herman Blomeier ◽  
Jessica Kruger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinases ◽  
Insulin Gene ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Insulin Gene Expression
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