Hematopoietic Stem Cell Trafficking: Regulated Adhesion and Attraction to Bone Marrow Microenvironment

2007 ◽  
Vol 1116 (1) ◽  
pp. 392-413 ◽  
Author(s):  
S. MENDEZ-FERRER ◽  
P. S. FRENETTE
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Microenvironment ◽  
Cell Trafficking ◽  
Hematopoietic Stem ◽  
Stem Cell Trafficking

Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1

Blood ◽  
2003 ◽  
Vol 102 (8) ◽  
pp. 2798-2802 ◽  
Author(s):  
Anthony D. Whetton ◽  
Yuning Lu ◽  
Andrew Pierce ◽  
Louise Carney ◽  
Elaine Spooncer
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Cell Biology ◽  
Critical Role ◽  
Hematopoietic Cell ◽  
Cell Trafficking ◽  
Hematopoietic Stem ◽  
Stem Cell Trafficking ◽  
Cell Chemotaxis

Abstract Hematopoiesis is sustained by the proliferation and development of an extremely low number of hematopoietic stem cells resident in the bone marrow. These stem cells can migrate from their bone marrow microenvironment and can be found at low levels in the peripheral blood. The factors that regulate egress or ingress of the stem cells from the marrow include cytokines and chemokines. This process of stem cell trafficking is fundamental to both stem cell biology and stem cell transplantation. We show that primitive hematopoietic cells with cobblestone area–forming cell activity express receptors for and display enhanced motility in response to a new class of stem cell agonists, namely lysophospholipids. These agents synergistically promote chemokinestimulated cell chemotaxis, a process that is crucial in stem cell homing. The response to lysophospholipids is mediated by Rac, Rho, and Cdc42 G proteins and the hematopoietic-specific guanyl nucleotide exchange factor Vav 1. Inhibitor studies also show a critical role for phosphatidylinositol 3 kinase (PI3K). Lipid mediators, therefore, regulate the critical process of primitive hematopoietic cell motility via a PI3K- and Vav-dependent mechanism and may govern stem cell movement in vivo. These results are of relevance to understanding stem cell trafficking during bone marrow transplantation.

Hematopoietic stem cell trafficking in liver injury

2005 ◽  
Vol 19 (10) ◽  
pp. 1225-1231 ◽  
Author(s):  
Evangelos Dalakas ◽  
Philip N. Newsome ◽  
David J. Harrison ◽  
John N. Plevris
Keyword(s):  
Stem Cell ◽  
Liver Injury ◽  
Hematopoietic Stem Cell ◽  
Cell Trafficking ◽  
Hematopoietic Stem ◽  
Stem Cell Trafficking

Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model

2016 ◽  
Vol 25 (4) ◽  
pp. 360-365 ◽  
Author(s):  
Frank J.T. Staal ◽  
Herman P. Spaink ◽  
Willem E. Fibbe
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Xenograft Model ◽  
Cell Trafficking ◽  
Hematopoietic Stem ◽  
Stem Cell Trafficking
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