High-dose chemotherapy of breast cancer: is the question answered?

1995 ◽  
Vol 13 (10) ◽  
pp. 2477-2479 ◽  
Author(s):  
M J Kennedy
Keyword(s):  
Breast Cancer ◽  
High Dose Chemotherapy ◽  
High Dose

High-dose chemotherapy and hematopoietic stem cell transplantation for breast cancer: Past or future?

2001 ◽  
Vol 28 (4) ◽  
pp. 377-388 ◽  
Author(s):  
Roy D. Baynes ◽  
Roger D. Dansey ◽  
Jared L. Klein ◽  
Caroline Hamm ◽  
Mark Campbell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Hematopoietic Stem

Gamma knife radiosurgery in patients with advanced breast cancer undergoing bone marrow transplant

2002 ◽  
Vol 97 ◽  
pp. 663-665 ◽  
Author(s):  
Kenneth J. Levin ◽  
Emad F. Youssef ◽  
Andrew E. Sloan ◽  
Rajiv Patel ◽  
Rana K. Zabad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
High Dose Chemotherapy ◽  
Advanced Breast ◽  
High Dose ◽  
Initial Management ◽  
Content Type ◽  
Fine Print

Object. Recent studies have suggested a high incidence of cognitive deficits in patients undergoing high-dose chemotherapy, which appears to be dose related. Whole-brain radiotherapy (WBRT) has previously been associated with cognitive impairment. The authors attempted to use gamma knife radiosurgery (GKS) to delay or avoid WBRT in patients with advanced breast cancer treated with high-dose chemotherapy and autologous bone marrow transplantation (HDC/ABMT) in whom brain metastases were diagnosed. Methods. A retrospective review of our experience from 1996 to 2001 was performed to identify patients who underwent HDC/ABMT for advanced breast cancer and brain metastasis. They were able to conduct GKS as initial management to avoid or delay WBRT in 12 patients following HDC/ABMT. All patients were women. The median age was 48 years (range 30–58 years). The Karnofsky Performance Scale score was 70 (range 60–90). All lesions were treated with a median prescription dose of 17 Gy (range 15–18 Gy) prescribed to the 50% isodose. Median survival was 11.5 months. Five patients (42%) had no evidence of central nervous system disease progression and no further treatment was given. Four patients were retreated with GKS and three of them eventually received WBRT as well. Two patients were treated with WBRT as the primary salvage therapy. The median time to retreatment with WBRT was 8 months after the initial GKS. Conclusions. Gamma knife radiosurgery can be effectively used for the initial management of brain metastases to avoid or delay WBRT in patients treated previously with HDC, with acceptable survival and preserved cognitive function.

scholarly journals ESTIC position paper: High-dose chemotherapy for breast cancer, investigation should continue

1999 ◽  
Vol 10 (8) ◽  
pp. 903-905 ◽  
Author(s):  
J. Crown ◽  
B. Coiffier ◽  
H. Cortés-Funes ◽  
Th. Guillaume ◽  
L. Kanz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Dose Chemotherapy ◽  
Position Paper ◽  
High Dose

No future for high-dose chemotherapy in breast cancer

2002 ◽  
Vol 3 (12) ◽  
pp. 715
Author(s):  
Emma Wilkinson
Keyword(s):  
Breast Cancer ◽  
High Dose Chemotherapy ◽  
High Dose

High-dose chemotherapy and stem-cell support in breast cancer

The Lancet ◽  
1998 ◽  
Vol 352 (9135) ◽  
pp. 1220
Author(s):  
Paolo Pedrazzoli ◽  
Gian Antonio Da Prada ◽  
Gioacchino Robustelli della Cuna
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Stem Cell Support ◽  
Cell Support
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