Polymorphisms in the DNA repair gene XRCC1 and survival of non-small cell lung cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 9585-9585 ◽  
Author(s):  
S. M. Yoon ◽  
H. J. Park ◽  
S. Y. Kim ◽  
J. H. Kim ◽  
S. S. Shin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene

An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer

2010 ◽  
Vol 38 (8) ◽  
pp. 5231-5241 ◽  
Author(s):  
Dorota Butkiewicz ◽  
Marek Rusin ◽  
Bożena Sikora ◽  
Antonina Lach ◽  
Mieczysław Chorąży
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene

P-740 Polymorphisms in the dna repair gene XRCC1 and survival of non-small cell lung cancer

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S313
Author(s):  
S. Song ◽  
E. Choi ◽  
H. Park ◽  
S. Yoon ◽  
S. Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene

DNA Repair Gene Polymorphisms Predict Favorable Clinical Outcome in Advanced Non–Small-Cell Lung Cancer

2009 ◽  
Vol 10 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Aristea Kalikaki ◽  
Maria Kanaki ◽  
Helen Vassalou ◽  
John Souglakos ◽  
Alexandra Voutsina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Clinical Outcome ◽  
Small Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Favorable Clinical Outcome

Role of DNA Repair Gene Polymorphisms in the Efficiency of Platinum-Based Adjuvant Chemotherapy for Non-Small Cell Lung Cancer

2011 ◽  
Vol 15 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Juliette Mathiaux ◽  
Valérie Le Morvan ◽  
Marina Pulido ◽  
Jacques Jougon ◽  
Hugues Bégueret ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Adjuvant Chemotherapy ◽  
Small Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals Potential Functional Variants in DNA Repair Genes Are Associated with Efficacy and Toxicity of Radiotherapy in Patients with Non-Small-Cell Lung Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Zhiguang Yang ◽  
Zhaoyu Liu
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Dna Repair Genes ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Repair Genes ◽  
Toxic Reactions

Background. Lung cancer is one of the leading causes of cancer-related deaths. Radiotherapy, either alone or with chemotherapy, is still the primary treatment for patients with non-small-cell lung cancer (NSCLC). There are variations in how patients with NSCLC respond to radiotherapy and how toxic the therapy is. DNA repair gene polymorphisms are related to cancer development; however, their association with radiotherapy outcomes remains unknown. We hypothesized that gDNA repair gene variation could affect the efficacy and toxicity of radiotherapy in patients with NSCLC. Methods. A total of 486 histologically confirmed patients with NSCLC were recruited from the Shengjing Hospital of China Medical University from July 2015 to September 2019. Eleven potentially functional single nucleotide polymorphisms (SNPs) in four DNA repair genes (XRCC1, XRCC2, XPD, and MSH2) were genotyped in these patients. A multiple factor logistic regression analysis was used to assess the association between these SNPs and the efficacy and toxicity of radiotherapy. Results. Three SNPs, rs25487 (XRCC1), rs3218556 (XRCC2), and rs13181 (XPD), were all significantly associated with the efficacy of radiotherapy. The allele frequencies of the rs25487 CC genotype (OR = 0.457, 95% CI = 0.259–0.804, p=0.006) and the rs3218556 AG or AA genotypes (AG genotype: OR = 0.664, 95% CI = 0.442–0.999, p=0.049; AA genotype: OR = 0.380, 95% CI = 0.181–0.795, p=0.008) were both significantly higher in the response group than in the nonresponse group. For rs13181, the radiotherapy efficacy was associated with the heterozygous genotype GT (OR = 1.663, 95% CI = 1.057–2.614,p=0.027). Statistically significant associations between radiation-induced toxic reactions and rs25487 (XRCC1), rs3218556 (XRCC2), and rs13181 (XPD) were also observed. The rs13181GT genotype was associated with lower toxic reactions than the TT genotype (OR = 1.680, 95% CI = 1.035–2.728,p=0.035). Conclusions. The variants rs25487 (XRCC1), rs3218556 (XRCC2), and rs13181 (XPD) all contribute to the efficacy and toxicity of radiotherapy in patients with NSCLC. Our findings may clarify the predictive value of DNA repair genes for prognosis in patients with NSCLC after radiotherapy. Further investigation of more genes and samples should be performed to confirm our findings.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer

2010 ◽  
Vol 101 (11) ◽  
pp. 2436-2442 ◽  
Author(s):  
Min Kim ◽  
Hyo-Gyoung Kang ◽  
Shin Yup Lee ◽  
Hyung Cheol Lee ◽  
Eung Bae Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Small Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Early Stage ◽  
Comprehensive Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene
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