Impact of post-surgical residual tumor volume on local control in radiotherapy for maxillary sinus cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 16518-16518
Author(s):  
A. G. Elhag ◽  
W. H. Elsawy ◽  
D. N. Khalifa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multivariate Analysis ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Local Control ◽  
Tumor Volume ◽  
Residual Tumor ◽  
Maxillary Sinus Cancer ◽  
Group D ◽  
Sinus Cancer

16518 Background: The aim was to study the influence of post-surgical gross residual tumor volume on local control of maxillary sinus cancer treated with radiotherapy combined with debulking surgery. Methods: Twenty-five patients with squamous cell carcinoma of the maxillary sinus treated by combined surgery and radiotherapy (50–65 Gy, median 60 Gy). Gross residual tumor volume (GRTV) after surgery was measured on computed tomograms obtained after surgery. Patients were classified according to GRTV as follows: group A, GRTV = 0 (microscopic residual, n = 5); group B, GRTV <10 cm3 (n = 11); group C, 10–40 cm3 (n = 5); and group D, =40 cm3 (n = 4). The relationship between local control and GRTV was analyzed using univariate and multivariate analysis. Results: The 2-year local control rate for all patients was 64%. The differences in local control rates between groups A, B and C were not significant (P > 0.05), but the rate was significantly lower in group D than in the other groups (65% at 2 years vs. 25% at 1 year, P < 0.001). Multivariate analysis showed that GRTV (P = 0.002) and histological differentiation (poorly differentiated histology was favorable, P = 0.035) were independent prognostic factors and that tumor stage and the sequence of treatment were not. Conclusions: Our data suggest that adequate, not complete, debulking associated with the proper dose of radiotherapy can provide satisfactory local control for patients with squamous cell carcinoma of the maxillary sinus. No significant financial relationships to disclose.

ANALYSIS OF EXPRESSION OF P63 AND CASPASE-3 AND THEIR PREDICTIVE VALUE IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF MAXILLARY SINUS

2019 ◽  
Vol 72 (12) ◽  
Author(s):  
Oleksandr V Kovtunenko ◽  
Anatoliy A Bakaiev ◽  
Ihor S Shponka
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell ◽  
Predictive Value ◽  
Caspase 3 ◽  
High Expression ◽  
Malignant Neoplasms ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Introduction: Maxillary sinus cancer is a malignant neoplasm with a prevalence of 3 to 5% of tumors in the head and neck and less than 1% of all malignant neoplasms. The role of p63 and caspase-3 and their predictive value in squamous cell carcinoma of maxillary sinus (SCCMS) remains an underdeveloped and controversial issue that determined the relevance of the study. The aim: To analyze the relationship between the level of expression of p63 and caspase-3 and clinical and morphological characteristics of squamous cell carcinoma of maxillary sinus and to determine their prognostic significance as immunohistochemical markers of tumor progression (relapse and metastases). Materials and methods: A comprehensive investigation with immunohistochemical study of squamous cell carcinoma of maxillary sinus of 103 patients with maxillary sinus cancer II - IV stage (T2-4 N0-3 M0) of the second clinical group was conducted. Results: The moderate and high expression rate of caspase-3 in the overall sample was 50.49% and 16.50% respectively, and one third of cases (33.01%) was characterized by a weak reaction. In the group without metastases (p <0.001), moderate expression of the marker (56.25%) prevailed; in the SCCMS group with metastases it was (60.87%). The mean level of expression of p63 in the examined patients with squamous cell carcinoma of maxillary sinus was 46.0%. The number of p63-positive specimens was statistically significantly (p = 0.034) higher in the SCCMS group with metastases. In patients with the development of squamous cell carcinoma of maxilla on the background of papilloma, a significantly higher (p <0.001) mean level of p63 expression was only moderate (90.91%) and high (9.09%). Conclusions: There was observed a relatively strong associate of the increase in the expression of caspase-3 with SCCMS metastases (p <0.001) and no correlation of immunohistochemical reaction of this marker with relapses. There was determined that the probability of metastases at high expression level of p63 is higher than in tumors with low and moderate level of the oncoprotein (p = 0.003). Based on the level of expression of p63, it is possible to predict the likelihood of development of SCCMS with papillomas (p <0.001); and the development of relapses of squamous cell carcinoma of maxillary sinus (p <0.001).

Is Radiation Therapy a Preferred Alternative to Surgery for Squamous Cell Carcinoma of the Base of Tongue?

2000 ◽  
Vol 18 (1) ◽  
pp. 35-35 ◽  
Author(s):  
William M. Mendenhall ◽  
Scott P. Stringer ◽  
Robert J. Amdur ◽  
Russell W. Hinerman ◽  
Giselle J. Moore-Higgs ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Local Control ◽  
Treatment Time ◽  
Overall Treatment Time ◽  
Regional Control ◽  
Base Of Tongue ◽  
Local Regional Control

PURPOSE: To evaluate irradiation alone for treatment of base-of-tongue cancer. PATIENTS AND METHODS: Two hundred seventeen patients with squamous cell carcinoma of the base of tongue were treated with radiation alone and had follow-up for ≥ 2 years. RESULTS: Local control rates at 5 years were as follows: T1, 96%; T2, 91%; T3, 81%; and T4, 38%. Multivariate analysis revealed that T stage (P = .0001) and overall treatment time (P = .0006) significantly influenced local control. The 5-year rates of local-regional control were as follows: I, 100%; II, 100%; III, 83%; IVA, 64%; and IVB, 65%. Multivariate analysis revealed that the following parameters significantly affect the probability of this end point: T stage (P = .0001), overall treatment time (P = .0001), overall stage (P = .0131), and addition of a neck dissection (P = .0021). The rates of absolute and cause-specific survival at 5 years were as follows: I, 50% and 100%; II, 81% and 100%; III, 65% and 76%; IVA, 42% and 56%; and IVB, 44% and 52%. Severe radiation complications developed in eight patients (4%). CONCLUSION: The likelihood of cure after external-beam irradiation was related to stage, overall treatment time, and addition of a planned neck dissection. The local-regional control rates and survival rates after radiation therapy were comparable to those after surgery, and the morbidity associated with irradiation was less.

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