Population-based study of the incidence, mortality and prognostic factors of small cell carcinoma of the cervix: Analysis of the Surveillance, Epidemiology and End Results database

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 5546-5546
Author(s):  
J. Chen ◽  
O. K. MacDonald ◽  
D. K. Gaffney
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Figo Stage ◽  
Lymph Node Involvement ◽  
Population Based ◽  
Small Cell ◽  
Cervix Uteri ◽  
Population Based Study ◽  
Node Involvement

5546 Background: Small cell carcinoma (SmC) is a rare histology of the cervix uteri that is generally associated with a poor prognosis. This is a population-based study of SmC using the Surveillance, Epidemiology and End Results (SEER). Methods: From 1977 to 2003, 290 women with SmC of the cervix uteri were identified. In addition, 27,527 patients with squamous cell carcinoma (SC) and 5231 with adenocarcinoma (AC) of the cervix were identified for comparison. The annual incidence of each histology was determined and examined for trend. The patient and disease characteristics at diagnosis were examined for each histology, and prognostic factors were evaluated for SmC. Mortality rates of SmC and other histologies were compared via log-rank tests. Results: Mean annual incidence of SmC was 0.03 per 100,000 women compared to 3.5 and 0.62 for SC and AC. A significant change in incidence was identified for SC and AC (p<0.05), but not for SmC (p=0.595). Patients with SmC were more likely to be treated with radiotherapy and to present with more advanced stage, lymph node involvement and distant metastasis than SC and AC (p<0.05). Survival rates for SmC at 2 and 5 years were 46.8% and 35.7%, which were worse compared to SC (HR 0.45; 95% CI: 0.36–0.57) and AC (HR 0.31; 95% CI: 0.25–0.39). The difference in survival is predominantly in patients with early stage, localized disease, and those treated with surgery ( Table ). Multivariate analysis of SmC, race, FIGO stage, age and hysterectomy alone significantly impacted prognosis (p<0.05), while year of diagnosis, lymph node involvement, tumor size, marital status and other treatment modality did not. Conclusions: SmC is an uncommon histologic variant of cervix cancer associated with a worse prognosis compared to SC and AC with a predilection for metastasis at diagnosis. FIGO stage, age and race are prognostic factors for survival. [Table: see text] No significant financial relationships to disclose.

scholarly journals Analysis of primary oral and oropharyngeal squamous cell carcinoma in Beijing inhabitants, China—a 10-year continuous study of a single center

2020 ◽  
Author(s):  
Xuexiao Bai ◽  
Jie Zhang ◽  
Li Wei
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Involvement ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Node Involvement

Abstract Backgroud The aim of the study was to evaluate whether Beijing inhabitants with oral and oropharyngeal squamous cell carcinoma(OSCC) differ from previous reports with regard to clinicopathological characteristics and prognosis, and study the influence of prognostic factors. Methods Consecutive cases of primary oral and oropharyngeal squamous cell carcinoma in Beijing patients admitted between 2004 and 2013 were analyzed retrospectively. Clinical data included age, sex, location, site, TNM stage, history of drinking and smoking, differentiation and follow up information. Results A total of 603 cases were included in this study. The male: female ratio was 1.1:1. The frequency of sites decreased in the order tongue, gingiva, buccal mucosa, oral floor, oropharynx, lip and palate. Differences in location, age and stage between males and females were statistically significant (P < 0.05). Whereas 65.3% of male patients smoked or drank, only 6.3% of female patients did so. The overall 5-year survival rate was 64%. Female patients have a worse prognosis than male. For patients who received surgery, tumor size, lymph node involvement were independent prognostic factors. Smoking and drinking were not prognostic factors. Conclusion Our study indicates that the clinical characteristics OSCC patients in Beijing is similar to some developed countries, both regarding male/female ratio, diagnostic age, prognosis, which is different from previous reports in other districts of China. Lymph node involvement was the most important prognostic factor, followed by tumor size, pathological grade.

Is Adjuvant Radiochemotherapy Always Mandatory in Patients with Resected N2 Non-Small Cell Lung Cancer?

2021 ◽  
Author(s):  
Samantha Taber ◽  
Joachim Pfannschmidt ◽  
Torsten T. Bauer ◽  
Torsten G. Blum ◽  
Christian Grah ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Adjuvant Treatment ◽  
Lymph Node Involvement ◽  
Small Cell ◽  
Small Cell Lung ◽  
Term Survival ◽  
Node Involvement ◽  
The Mean

Abstract Background In patients with non-small cell lung cancer (NSCLC), the pathologic union for international cancer control (UICC) stage IIIA is a heterogeneous entity, with different forms of N2-lymph node involvement representing different prognoses. Although a multimodality treatment approach, including surgery, systemic therapy, and/or radiotherapy, is almost always recommended, in this retrospective observational study, we sought to determine whether long-term survival might be possible in selected patients who are treated with complete surgical resection alone. Methods Between 2013 and 2018, we retrospectively identified 24 patients with NSCLC (16 men and 8 women), who were found to have pathologic N2-lymph node involvement, and were treated with complete surgical lung resection and systematic mediastinal and hilar lymph node dissection but no neoadjuvant or adjuvant treatment. Results The most frequent reason (n = 14) for forgoing adjuvant treatment was patient refusal. The mean overall survival (OS) was 34.5 months (interquartile range [IQR]: 15.5–53.5 months). The mean disease-free survival (DFS) was 18 months (IQR: 4.75–46.75 months). We identified five patients who survived at least 5 years without recurrence (21%). In each of these cases, the nodal metastases were restricted to a single level and no extracapsular lymph node involvement were detected. Additionally, worse DFS was associated with pT3/4 (vs. a lower T-stage), as well as microscopic lymphovascular invasion. Conclusion Although the small sample size precludes any definitive conclusions, it was possible to demonstrate that long-term survival without neoadjuvant and adjuvant treatment is possible in some patients if complete tumor and nodal resection is performed.

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