Next-generation RNA sequencing versus RNA microarray gene expression profiling for personalized medicine approaches in oncology: Lessons from relapsed and refractory neuroblastoma patients from the Neuroblastoma Medulloblastoma Translational Research Consortium (NMTRC).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e22083-e22083
Author(s):  
Christina Kay Lettieri
Author(s):  
P. Sivashanmugam ◽  
Arun C. ◽  
Selvakumar P.

The physical and biological activity of any organisms is mainly depended on the genetic information which stored in DNA. A process at which a gene gives rise to a phenotype is called as gene expression. Analysis of gene expression can be used to interpret the changes that occur at biological level of a stressed cell or tissue. Hybridization technology helps to study the gene expression of multiple cell at a same time. Among them microarray technology is a high- throughput technology to study the gene expression at transcription level (DNA) or translation level (Protein). Analysis the protein only can predict the accurate changes that happens in a tissue, when they are infected by a disease causing organisms. Protein microarray mainly used to identify the interactions and activities of proteins with other molecules, and to determine their function for a system at normal state and stressed state. The scope of this chapter is to outline a detail description on the fabrication, types, data analysis, and application of protein microarray technology towards gene expression profiling.


2015 ◽  
Vol 101 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Chunyan Xing ◽  
Ronghua Zhang ◽  
Jiyun Cui ◽  
Yonghong Li ◽  
Guanhua Li ◽  
...  

Nutrition ◽  
2004 ◽  
Vol 20 (1) ◽  
pp. 134-138 ◽  
Author(s):  
Paska A Permana ◽  
Angelo Del Parigi ◽  
P.Antonio Tataranni

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