Localized vagina/uterus rhabdomyosarcoma (VU RMS): Results of a pooled analysis from four international cooperative groups.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 10063-10063
Author(s):  
Veronique Minard-Colin ◽  
James Robert Anderson ◽  
Gianni Bisogno ◽  
Dominique Schwob ◽  
David A. Rodeberg ◽  
...  
Keyword(s):  
Pooled Analysis ◽  
Cooperative Groups

Parameningeal rhabdomyosarcoma: Results of a pooled analysis from U.S. and European Cooperative Groups.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 9529-9529 ◽  
Author(s):  
J. H. Merks ◽  
G. L. De Salvo ◽  
C. Bergeron ◽  
G. Bisogno ◽  
A. Rey ◽  
...  
Keyword(s):  
Pooled Analysis ◽  
Cooperative Groups

scholarly journals Demographic and Treatment Variables Influencing Outcome for Localized Paratesticular Rhabdomyosarcoma: Results From a Pooled Analysis of North American and European Cooperative Groups

2018 ◽  
Vol 36 (35) ◽  
pp. 3466-3476 ◽  
Author(s):  
David O. Walterhouse ◽  
Donald A. Barkauskas ◽  
David Hall ◽  
Andrea Ferrari ◽  
Gian Luca De Salvo ◽  
...  
Keyword(s):  
Tumor Size ◽  
Proportional Hazards ◽  
Selection Procedure ◽  
Pooled Analysis ◽  
Demographic Variables ◽  
Cooperative Groups ◽  
Treatment Variable ◽  
Treatment Choices ◽  
Prognostic Features ◽  
Kaplan Meier

Purpose Treatment recommendations for localized paratesticular rhabdomyosarcoma (PT RMS) differ in North America and Europe. We conducted a pooled analysis to identify demographic features and treatment choices that affect outcome. Patients and Methods We retrospectively analyzed the effect of nine demographic variables and four treatment choices on event-free survival (EFS) and overall survival (OS) from 12 studies conducted by five cooperative groups. Results Eight hundred forty-two patients with localized PT RMS who enrolled from 1988 to 2013 were included. Patients age ≥ 10 years were more likely than younger patients to have tumors that were > 5 cm, enlarged nodes (N1), or pathologically involved nodes ( P ≤ .05 each). With a median follow-up of 7.5 years, Kaplan-Meier estimates for 5-year EFS and OS were 87.7% and 94.8%, respectively. Of demographic variables, cooperative group, era of enrollment, age category, tumor size, Intergroup Rhabdomyosarcoma Study group, and T stage affected EFS ( P ≤ .05 each). Surgical assessment of regional nodes, which was performed in 23.5% of patients—usually in those age ≥ 10 years or with suspicious or N1 nodes—was the only treatment variable associated with EFS by univariable and multivariable analyses ( P ≤ .05 each) in patients age ≥ 1 year. A variable selection procedure on a proportional hazards regression model selected era of enrollment, age, tumor size, and surgical assessment of regional nodes as significant ( P ≤ .05 each) in the EFS model, and era of enrollment, age, tumor size, and histology ( P ≤ .05 each) in the OS model. Conclusion Localized PT RMS has a favorable prognosis. Age ≥ 10 years at diagnosis and tumor size larger than 5 cm are unfavorable prognostic features. Surgical assessment of regional nodes is important in patients age ≥ 10 years and in those with N1 nodes as it affects EFS.

scholarly journals Parameningeal rhabdomyosarcoma in pediatric age: results of a pooled analysis from North American and European cooperative groups

2014 ◽  
Vol 25 (1) ◽  
pp. 231-236 ◽  
Author(s):  
J.H.M. Merks ◽  
G.L. De Salvo ◽  
C. Bergeron ◽  
G. Bisogno ◽  
A. De Paoli ◽  
...  
Keyword(s):  
North American ◽  
Pooled Analysis ◽  
Cooperative Groups ◽  
Pediatric Age

scholarly journals Prognostic Factors for Outcome in Localized Extremity Rhabdomyosarcoma. Pooled Analysis from Four International Cooperative Groups

2015 ◽  
Vol 62 (12) ◽  
pp. 2125-2131 ◽  
Author(s):  
Odile Oberlin ◽  
Annie Rey ◽  
Kenneth L.B. Brown ◽  
Gianni Bisogno ◽  
Ewa Koscielniak ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Pooled Analysis ◽  
Cooperative Groups

scholarly journals Localized vaginal/uterine rhabdomyosarcoma-results of a pooled analysis from four international cooperative groups

2018 ◽  
Vol 65 (9) ◽  
pp. e27096 ◽  
Author(s):  
Veronique Minard-Colin ◽  
David Walterhouse ◽  
Gianni Bisogno ◽  
Helene Martelli ◽  
James Anderson ◽  
...  
Keyword(s):  
Pooled Analysis ◽  
Cooperative Groups

scholarly journals Prognostic Factors in Metastatic Rhabdomyosarcomas: Results of a Pooled Analysis From United States and European Cooperative Groups

2008 ◽  
Vol 26 (14) ◽  
pp. 2384-2389 ◽  
Author(s):  
Odile Oberlin ◽  
Annie Rey ◽  
Elizabeth Lyden ◽  
Gianni Bisogno ◽  
Michael C.G. Stevens ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Metastatic Disease ◽  
Primary Tumor ◽  
Univariate Analysis ◽  
Bone Marrow Involvement ◽  
Pooled Analysis ◽  
Current Therapy ◽  
Cooperative Groups ◽  
Relative Risks ◽  
Metastatic Sites

Purpose To identify risk factors associated with outcome in children with metastatic rhabdomyosarcoma in a large cohort of patients Patients and Methods Pooled data were obtained from 788 patients treated in nine studies performed by European and American cooperative groups. Clinical factors, including age, histology, site of primary, and site(s) and number of sites of metastatic disease, were correlated with event-free survival (EFS) and overall survival (OS). Results Seven hundred eighty-eight patients were eligible for analysis. The 3-year OS and EFS were 34% (SE, 1.7) and 27% (SE, 1.6), respectively. By univariate analysis, 3-year EFS was significantly and adversely influenced by age, alveolar histology, location of primary tumor in unfavorable site (defined as extremity and “other” sites), presence of three or more sites of metastatic disease, and the presence of bone or bone marrow involvement. By multivariate analysis, EFS was strongly correlated to all factors except histology. Relative risks were 1.6 for age younger than 1 year or at least 10 years, 1.4 for unfavorable site of primary tumor, 1.4 for bone or bone marrow involvement, 1.4 for three or more metastatic sites. EFS was 50% for patients without any of these four adverse factors and was respectively 42%, 18%, 12%, and 5% in patients with one, two, three, or four factors (P < .0001). Conclusion This analysis identified subsets of patients with metastatic rhabdomyosaroma with different outcomes to current therapy and offers a strategy to define patient candidates for experimental approaches to treatment.

Prognostic factors of localized extremity rhabdomyosarcomas: The results of a pooled analysis from U.S. and European cooperative groups.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 9505-9505
Author(s):  
O. Oberlin ◽  
A. Rey ◽  
K. L. Brown ◽  
G. Bisogno ◽  
E. Koscielniak ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Pooled Analysis ◽  
Cooperative Groups

1554: 6 Year Long Term Clinical and Urodynamical Outcome and Retreatment Rates of High Energy Transurethral Microwave Thermotherapy: Multicenter European Pooled Analysis

2004 ◽  
Vol 171 (4S) ◽  
pp. 410-410
Author(s):  
Christian Seitz ◽  
Bob Djavan ◽  
Michael Dobrovits ◽  
Matthias Waldert ◽  
Saeid Alavi ◽  
...  
Keyword(s):  
High Energy ◽  
Pooled Analysis ◽  
Transurethral Microwave Thermotherapy
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